Table 1 Alterations within kinase signaling cascades and their regulators across adult and pediatric high-grade gliomas [23, 24]. The frequency of gene mutations and copy number alterations were obtained from the cBioPortal for Cancer Genomics using two data sets, Glioblastoma Multiforme (TCGA, Firehose Legacy) and Pediatric Brain Cancer (CPTAC/CHOP, Cell 2020). AMP – amplification; CNA – copy number alterations; HOMDEL – homozygous deletion; pHGG – pediatric high-grade glioma
Gene | Cancer Type | Frequency of mutation | Frequency of CNA |
|---|---|---|---|
EGFR | Glioblastoma | 26.6% | 43.8% (AMP) |
pHGG | 4% | 5% (AMP) | |
PTEN | Glioblastoma | 31.0% | 9.7% (HOMDEL) |
pHGG | – | 5% (HOMDEL) | |
PIK3CA | Glioblastoma | 11.0% | 2.8% (AMP) |
pHGG | 8.0% | – | |
PIK3R1 | Glioblastoma | 11.4% | 0.3% (HOMDEL) |
NF1 | Glioblastoma | 11% | 1.9% (HOMDEL) |
pHGG | 24% | – | |
CDKN2A | Glioblastoma | 0.7% | 57.4% (HOMDEL) |
pHGG | – | 35.0% (HOMDEL) | |
KIT | Glioblastoma | 1.0% | 9.2% (AMP) |
pHGG | – | 15% (AMP) | |
PDGFRA | Glioblastoma | 3.8% | 12.8% (AMP) |
pHGG | 8.0% | 10% (AMP) |