Fig. 8

NSCLC cell-derived exosomal circATP9A induces macrophages M2 polarization. Notes: (A) Representative images of A549 cells after incubation with PKH26-labeled NSCLC-EVs; (B) Co-cultivation mode diagram; (C) Flow cytometric analysis of the expressions of CD206/ HLA-DR in macrophages treated with exosomes with different circATP9A levels. Numerical values denote the relative fluorescence intensity; (D) The proliferation ability of A549 cells was assessed by CCK8 assay [(EXO and co-cultured with T)P-1 (Mφ)]; (E) The invasion ability of A549 cells was assessed by CCK8 assay [(EXO and co-cultured with T)P-1 (Mφ)]; (F) A schematic model of this study