Fig. 2

TANs are attracted by necrosis cancer tissue releasing HMGB1 and move to TME, where they are polarized and activated as N2-type TANs by TGF-β and G-CSF secreted from cancer cells. These TANs promote the ferroptosis of cancer cells by MPO, which fuels tumor progression. Ferroptotic cancer cells attract TAMs by other DAMPs, including 4-HNE, 8-OHG, and SAPE-OOH, and these TAMs are polarized into pro-tumor M2-type TAMs. Ferroptotic cancer cells amplify immune response by inducing ICD to mature and activate APCs