Fig. 9

Schematic diagram displays the function of RGCC in promoting TNBC lung-tropic metastasis. The hyper-methylation of CEBPA (a transcription inhibitor) in lung-specific metastatic cancer cells leads to a reduced CEBPA and an increased RGCC. The enhanced RGCC interacts with PLK1 resulting in its higher kinase activity, phosphorylation of AMPKα2 and downstream mitochondrial oxidative phosphorylation and fatty acid oxidation activation, thus boosting the lung-tropic metastasis and colonization of TNBC