Skip to main content
Fig. 9 | Journal of Experimental & Clinical Cancer Research

Fig. 9

From: HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling

Fig. 9

Schematic representation of the effect of HDAC1/2 inhibition on MC/EOC adhesion. HDAC1/2 inhibition downregulates the expression of Talin-1 and other cytoskeletal regulators. This alters the Actin network leading to α5β1 Integrin inactivation and impairing FN-1 secretion and eventually inhibiting MC/EOC adhesion

Back to article page

Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

Contact us