Fig. 6
From: Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy
Ru1 negatively regulates genes involved in OXPHOS. A Principal component (PC) analysis of Control-, Ru1- and Ru1-met-treated Panc185 spheres (100µM, 24 h). B Summary of the number of genes transcriptional modulated (up or down) compared to Control in Ru1- and Ru1-met-treated Panc185 or PancA6L spheres (100µM, 24 h). C-D Gene sets enriched in the transcriptional profile of Panc185 spheres treated with Ru1 (100µM, 24 h) compared to untreated Controls. Shown are the NES (normalized enrichment score) values for each pathway using the Hallmark or KEGG genesets, with nominal p value of <0.05 and FDR < 25%. E-F Example enrichment plots for Oxidative Phosphorylation using the Hallmark or KEGG genesets. For (F), a heatmap of modulated genes was included