Fig. 7
From: Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy
Systems biology of pancreatic cancer and genes affected by Ru1. A Resulting network derived from the probabilistic graphical model (PGM) analyses. Shown are the 11 functional color-coded nodes, determined based on the mean-centered expression for the 2,000 genes with the most significant variation. B Network Heatmap showing the genes with the greatest variability between Ru1 and Control or Ru1 and Ru1-met. Green=under expressed, Red= over expressed. C Genes located within the mitochondria node (Node 10) that are significantly decreased between Ru1 and Control or Ru1 and Ru1-met. D Functional activity of the nodes comparing Control, Ru1 and Ru1-met. * p < 0.05, *** p < 0.001, as determined by one-way ANOVA with Tukey post-test. E Delta flux activities for Ru1-treated Panc185 or PancA6L cell compared to Control. In all cases, the indicated metabolic pathways decrease upon Ru1 treatment