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Fig. 14 | Journal of Experimental & Clinical Cancer Research

Fig. 14

From: Caloric restriction and metformin selectively improved LKB1-mutated NSCLC tumor response to chemo- and chemo-immunotherapy

Fig. 14

Best treatment effect obtained in intramuscular K and KL tumours in immunocompetent mice: KRASG12D (A) and KRASG12D/LKB1del (B) tumor volumes on days 35 and 31 of treatment respectively, the time-point when treatment benefit was greatest. Two-way ANOVA was used for statistical analysis (*p < 0.05, **p < 0.01, **** p < 0.0001). Error bars indicate SEM

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