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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Caloric restriction and metformin selectively improved LKB1-mutated NSCLC tumor response to chemo- and chemo-immunotherapy

Fig. 6

In vitro effect of metformin and CR treatments on PI3K/AKT proliferative pathway: Representative immunoblot analysis of total and different phosphorylated forms of the serine/threonine kinase AKT in KRASG12D (A) and KRASG12D/LKB1del(B) cell lines. C-F Bar graphs of the quantification analysis of the different active forms of AKT normalized on RAN, used as housekeeping. Proteins were extracted after 72 h of treatment with 2 mM of metformin (MET) and 50% caloric restriction (CR). Non-treated cells were used as control. One-way ANOVA was used for statistical analysis and no statistically significant results were highlighted. Error bars indicate SD

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