Fig. 9

Graph of body weight of mice bearing K and KL tumours: Body weight of KRAS^G12D (A) and KRAS^G12D/LKB1^del (B) mice used in Fig. 10. Untreated mice (CTRL) were compared to mice treated with DDP or DDP/MET/CR. The treatment schedule was well-tolerated, as the body weight lost during the fasting period was regain within 24 h. Intramuscular inoculation of KL cells, induced a massive weight loss in immunocompetent mice