Fig. 1
From: Transcription factors in fibroblast plasticity and CAF heterogeneity
Schematic representation of the main transcription factors involved in normal fibroblasts conversion into myofibroblasts during wound healing, fibrosis and cancer. EN1-positive dermal fibroblasts are major contributors toward wound repair. The major TFs upregulated or downregulated during fibroblast activation due to wound healing, fibrosis or cancer are reported. RUNX2 identifies both wound fibroblasts and the “early wound CAF” subtype. CSL complex with p53, ATF3 or AR to act as transcriptional repressor control of early CAF activation. Created with BioRender.com