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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: LncRNA AL139294.1 can be transported by extracellular vesicles to promote the oncogenic behaviour of recipient cells through activation of the Wnt and NF-κB2 pathways in non-small-cell lung cancer

Fig. 1

Screening of NSCLC-related lncRNAs in serum EVs. A Western blotting tested the specific markers of EVs (CD63, TSG101, and CD9) and EV-negative markers (Calnexin and GAPDH). Scanning electron microscopy was used to image the morphologies of serum EVs from healthy participants (B) and patients with NSCLC (C). A potentiometric analyzer was used to examine the size of serum EVs from healthy individuals (D) and patients with NSCLC (E). F Heat map shows lncRNAs differentially expressed in the serum EVs of patients with NSCLC. G Volcano plot shows the dysregulated lncRNAs in EVs. H The levels of the top 45 most upregulated lncRNAs in the serum EVs of patients with NSCLC were detected by qPCR. I The dot plots show the relative levels of serum AL139294.1 in EVs in the healthy subset (n = 30) and the NSCLC subset (n = 30). **P < 0.01

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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