Fig. 1

Screening of DEPs in GC tissue based on label-free relative quantitative proteomics. A Protein ANalysis through Evolutionary Relationships (PANTHER 9.0) for the analysis of the protein classes of DEPs between GC patients and healthy controls. B The results from the pathway enrichment analysis of the DEPs were divided into four pathways, and the second pathway, genetic information processing, was particularly significant. C The top ten most statistically significant enriched pathways, most of which were involved in RNA splicing and metabolism. D Protein‒protein interaction analysis of DEPs. The circled RNA-binding proteins and splicing-involved proteins interacted in clusters, and MAGOH was located at the node between the splicing-related proteins and the ribosome-related proteins. E Schematic representation of the functional enrichment analysis of proteins interacting with MAGOH. F Schematic diagram of pathways involving MAGOH and its interacting proteins visualized by OmicsBean analysis