Fig. 3
From: Unraveling the complexity of STAT3 in cancer: molecular understanding and drug discovery
STAT3 regulates the aerobic glycolysis, lipid metabolism, glutamine metabolism and energy production in tumor cells. The STAT3 activation regulates these metabolic reprogramming through the transcriptional regulation of genes involved in these processes, which contribute to multiple hallmarks of cancer including proliferation, immunosuppression, cancer stemness and drug resistance. Moreover, the mtSTAT3 accelerates ETC activity, decreases ROS production and MPTP opening, and promotes the calcium retention via binding to GRIM-19, which provides privileged advantages for the cancer progression. Created with BioRender.com