Fig. 3

Human AITL malignant and healthy Tfh cells show increased choline pathway activity compared to other healthy CD4 T-cell subsets. A Heatmap for GSEA data of 48 genes implicated in the CDP-choline pathway for AITL patient Tfh cells (n = 8), healthy Tfh cells (n = 12), central memory T cells (Tcm) (n = 6), effector memory T cells (Tem) (n = 6), naive T cells (Tn) (n = 6), regulatory T cells (T reg) (n = 13) and stem memory T cell (Tscm) (n = 6). The corresponding GSEA for the choline pathway signature genes is indicated in (A, right panel). For all genes with enrichment score > 0 (black bars in the pink zone), expression is upregulated. Kolmogrov-Smimov (KS) test. B Reactome choline pathway analysis for GSEA data of the same T-cell populations as mentioned in (A) was performed. Bubble representation (Bubbles size and numbers represents the sample enrichment score (SES), p-values are indicated in Supplementary Table 1)