Fig. 4
From: EGR1 suppresses HCC growth and aerobic glycolysis by transcriptionally downregulating PFKL
EGR1 suppressed aerobic glycolysis in HCC cells. A The GSEA analysis using hallmark gene sets in EGR1 overexpressing PLC/PRF5 cells and the result showed that EGR1 overexpression downregulated glycolysis pathway. B The GSEA analysis using hallmark gene sets in EGR1 knockout MHCC97H cells and the result revealed that EGR1 knockout upregulated glycolysis pathway. C, D, E, F The impact of EGR1 on glucose uptake, extracellular lactate levels, extracellular acidification rates (ECARs), and ATP levels was investigated. ***P < 0.001, ****P < 0.0001