Fig. 3
From: JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors
STAT3 expression is significantly prognostic in patients with stromal-rich tumors. Representative images of negative, weak, moderate, and strong IHC staining for pSTAT3tyr705 in CRC tissue from patient cohort 1 (A). Histogram showing the distribution of weighted histoscores for pSTAT3tyr705 quantified in the tumor cell nuceli of cohort 1 (B). Kaplan Meier curve showing the association between tumor nuclear expression of pSTAT3tyr705 and CSS in the full patient cohort 1(n = 660) (C). Bar plot showing the distribution of weighted histoscores for pSTAT3tyr705 across TSPlow and TSPhigh cases (D). Kaplan Meier survival analysis showing tumor nuclear pSTAT3tyr705 expression and CSS in TSPlow (E) and TSPhigh cases (F). Kaplan Meier survival curve showing the association between a combined score of pSTAT3tyr705 and pSTAT3ser727 expression and CSS in TSPhigh cases (G). Representative image of multiplex IF staining for pSTAT3tyr705 and pSTAT3ser727 in CRC tissue from patient cohort 1 with arrows highlighting the dual positive cells (H). Kaplan Meier curves showing the association between pSTAT3tyr705 expression and CSS in the TransSCOT clinical trial patient cohort (n = 1820) relative to treatment type (I-J) and treatment duration (K-L). Significance set to p < 0.05*, p < 0.005**, p < 0.0005***