Fig. 1

Transcriptomic profiling and functional enrichment analysis in docetaxel-resistant prostate cancer organoid models. A Venn diagram illustrating the overlap of differentially expressed genes (DEGs) in MSK-PCa3, MSK-PCa7, and PM154 prostate cancer cell lines, as referenced from the GSE162285 dataset. B Volcano plot displaying DEGs in MSK-PCa cell lines. The x-axis represents the log2-fold change (log2FC), while the y-axis shows the negative log10 of the false discovery rate (FDR)-adjusted p value (-log10(FDR p value)). Genes with significant differential expression are highlighted; those with Log2FC > 1 and -log10(FDR p value) > 1.5 are in red (upregulated), while those with Log2FC < -1 and -log10(FDR p value) > 1.5 are in green (downregulated). C, D Bubble chart of enriched biological processes and cellular components among DEGs, with bubble size indicating gene count and colour representing p value significance. E, F Molecular function enrichment analysis and pathway analysis bubble chart of DEGs presented as a bubble chart, where bubble size indicates the gene count and colour the p value significance