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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: TRIM25 promotes glioblastoma cell growth and invasion via regulation of the PRMT1/c-MYC pathway by targeting the splicing factor NONO

Fig. 5

TRIM25 promotes K63-linked ubiquitination of NONO. A Western blotting analysis of NONO ubiquitination levels in the indicated transfected LN229 and U251 cells. B Western blotting analysis of HA-NONO ubiquitination levels in the indicated transfected HEK293 cells. C qRT-PCR analysis of NONO mRNA levels in transfected LN229 and U251 cells, relative to controls. D Western blotting analysis of NONO protein levels in TRIM25-knockdown cells. E Western blotting analysis of NONO via co-IP assays using K48-linked specific polyubiquitin antibody in the indicated transfected LN229 and U251 cells. F Western blotting analysis of NONO via co-IP assays using K63-linked specific polyubiquitin antibody in the indicated transfected LN229 and U251 cells

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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