Fig. 3

ZCCHC4 promotes tumor growth in vivo. NC or ZCCHC4-OE HCT-116 cells were implanted subcutaneously in nude mice, and tumor nodules were formed subcutaneously in both groups. (A-B) In vivo imaging showing the size and location of the tumors in the two groups of mice. (C) subcutaneous tumor volume growth curves in the two groups of mice. (D) Size of the tumor mass. (E) comparison of the weight of the tumors in the mice after death. (F) Comparison of survival time between the two groups of mice. (G) detection of ZCCHC4 and Ki67 indexes in tumor samples of the two groups by IHC