Table 2 Univariate and multivariate analyses of survival in patients with CRC (Cox proportional hazards regression model)

Age

1.315

0.906–1.909

0.149

>55 VS ≤ 55

Gender

0.885

0.670–1.412

0.973

Female VS male

Tumor site

1.191

0.786–1.806

0.409

Colon VS Rectum

Tumor size

1.419

0.922–2.184

0.111

>3.5 cm VS ≤ 3.5 cm

Differentiation degree

4.153

2.501–6.896

0.000

2.406

1.635–3.542

0.001

Poor VS High/median

Vascular invasion

1.333

0.872–1.811

0.203

Positive VS negative

Nerve invasion

1.020

0.777–1.295

0.265

Positive VS negative

TNM stage

1.972

1.300–2.991

0.001

2.442

1.291–4.620

0.006

I/II VS III/IV

ZCCHC4 expression

2.503

1.71–3.663

0.000

2.352

1.467–3.772

0.000

Decreased VS Non-decreased