Fig. 3

Association between IL-8 levels and survival and monocytes and neutrophils in NSCLC patients treated with nivolumab. Overall survival analysis of baseline serum IL-8 levels in CheckMate 017 (A) and CheckMate 057 (B) trials. C Association between serum IL-8 levels and tumor mRNA expression of CXCL8, peripheral monocyte counts, blood neutrophil counts, IFNγ-related gene signature and the T-cell-related mRNA signature in patients with NSCLC (CheckMate 017 and CheckMate 057). The color intensity of the circles indicates the Spearman’s correlation coefficient of the association. Darker red, larger dots represent a greater correlation between serum IL-8 level and the indicated factor; darker blue, larger dots represent a greater negative correlation between serum IL-8 level and the indicated factor. Modified from Schalper, ref. [30]; copyright © 2020, Springer Nature