Fig. 2
Association of tumour size change and PFS with organoid response to 5-FU & oxaliplatin. A DRCs of organoid sensitivity to 5-FU & oxaliplatin combination treatment screened in a 1.8:1 ratio. B Scatterplots show the correlation between patient response (% size change during treatment) and organoid response measured (GRAUC) for 5-FU & oxaliplatin combination treatment screened in a 1.8:1 ratio. C Kaplan-Meier progression-free survival curves of patients stratified by organoid sensitivity to 5-FU & oxaliplatin, based on normalized GRAUC (cut-off upper tertile = 0.63). Censoring events are indicated by vertical bars on the corresponding curve. The table underneath each plot denotes the numbers at risk. Log-rank test-based p value is shown. Abbreviations: 5-FU (5-fluorouracil), DRC (drug response curve), GRAUC (area under the growth rate inhibition curve), PFS (progression-free survival)