Fig. 3
Association of tumour size change and organoid response to irinotecan-based treatment and 5-FU monotherapy. A DRCs of organoid sensitivity to 5-FU & SN-38 combination treatment. B Scatterplots show the correlation between patient response (% size change during treatment) and organoid response measured (GRAUC) for (5-FU &) SN-38. C DRCs of organoid sensitivity to 5-FU monotherapy. D Scatterplots show the correlation between patient response (% size change during treatment) and organoid response measured (GRAUC) for 5-FU monotherapy. Abbreviations: 5-FU (5-fluorouracil), DRC (drug response curve), CTG (CellTiter-Glo), GRAUC (area under the growth rate inhibition curve), SN-38 (active metabolite of irinotecan)