Fig. 3

High PLD2 expression in OC patients leads to a transcriptomic rewiring of hypoxia and stemness genes. (A) Heatmaps showing the expression z scores of stem-associated genes or hypoxia response genes whose expression was correlated with PLD2 in the GSE18520 OC patient database. (B) Expression levels of PLD2 and selected stem-associated or hypoxia response genes correlated with PLD2 in the OC patient database GSE18520. Box plots showing gene expression in patients in tumoral Cluster 1 (T1; light blue), tumoral Cluster 2 (T2; dark blue), or nontumor tissue (NT; red). Box plots representing the centreline, median; box limits, 25th and 75th percentiles. For B data were compared using Student’s t tests. Asterisks indicate statistical significance with respect to NT tissue. *p < 0.05; **p < 0.01; ***p < 0.001