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Table 2 The implications of ERO1α in tumors

From: Biological mechanisms and clinical significance of endoplasmic reticulum oxidoreductase 1 alpha (ERO1α) in human cancer

Cancer type

Ref.

Biological behavior

EMT

Angiogenesis

Xenograft in mice

Prognostic significance (Patients with ERO1A +/high)

Breast cancer

[93]

-

-

-

-

RFS↓

[87]

-

-

CD31(KD↓, OE↑), HUVEC(OE↑)

Lung metastasis (KD↓), OS (KD↓)

-

[70]

KD(NS)

-

-

Tumor growth (KD↓, OE↑), OS (KD↑, OE↓)

-

[94]

-

-

CD31 (KD↓, OE↑)

Tumor growth (KD↓, OE↑)

OS↓, #

[95]

-

-

 

Tumor growth (KD↓), lung metastasis (KD↓)

DFS↓, OS↓, #

[96]

KO↓

-

HUVEC (KO↓)

Tumor growth (KO NS), lung metastasis (KO↓)

OS (NS)

Lung cancer

[97]

-

-

-

-

RFS↓

[64]

-

-

-

-

RFS↓, OS↓, DFS↓

[65]

KD↓, OE↑

KD↓, OE↑

-

Tumor metastasis (KD↓, OE↑)

RFS↓, OS↓

[67]

KD↓

-

-

-

OS↓

[66]

KD↓, OE↑

-

-

Tumor growth (KO↓)

-

[68]

-

-

-

-

DFS↓, #

Bile duct cancer

[63]

KD↓, OE↑

KD↓, OE↑

-

-

DFS (NS), OS↓, #

Prostate cancer

[71]

KD↓

-

-

-

-

Pancreatic cancer

[99]

KD↓

-

-

Tumor growth (EN460↓),

OS↓, DFS ↓

liver metastasis (EN460↓), OS (EN460↓)

[69]

KD↓, OE↑

-

-

Tumor growth (KD↓, OE↑)

-

[68]

KD↓, OE↑

-

-

Tumor growth (KD↓, OE↑)

OS↓, #

Gastric cancer

[100]

KD↓

-

-

-

RFS↓, OS↓

Colon cancer

[101]

KD (NS)

KO↓

-

Tumor growth (KO↓)

-

Liver cancer

[58]

KD↓, OE↑

KD↓, OE↑

HUVEC (KD↓, OE↑), CD34 (KD↓, OE↑)

Lung metastasis (KD↓, OE↑)

RFS↓, OS↓

Cervical cancer

[63]

KO↓

KO↓

-

Tumor growth (KO↓)

OS↓

  1. Duplicate data in different references was deleted and only one was retained. EMT, epithelial–mesenchymal transition; NS, no significance; KD, knockdown; KO, knockout; OE, overexpression; EN460, ERO1α inhibitor; HUVEC, human umbilical vein endothelial cells; OS, overall survival; RFS, recurrence-free survival; DFS, disease-free survival; #, Independent prognostic factor; -, none.