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Table 1 Relationship between the serum CirExo-ADAM17 levels and clinicopathological features of patients with colorectal cancer (CRC).

From: Tumor-derived exosomal ADAM17 promotes pre-metastatic niche formation by enhancing vascular permeability in colorectal cancer

Parameter

Number of patients

CirExo-ADAM17 level

χ2

P-value

Number

%

<median

≥median

Gender

      

Male

40

50

17

23

1.251

0.2634

Female

40

50

22

18

  

Age, years

      

< 60

38

47.5

19

19

0.04527

0.8315

≥ 60

42

52.5

20

22

  

Tumor site

      

Colon

38

47.5

21

17

1.229

0.2676

Rectal

42

52.5

18

24

  

Tumor size, cm

      

< 5

43

53.75

25

18

3.281

0.0701

≥ 5

37

46.25

14

23

  

Tumor grade

      

Moderate/well

39

48.75

23

16

3.184

0.0744

Poor

41

51.25

16

25

  

Lymphovascular invasion

      

Absence

35

43.75

25

10

12.81

0.0003**

Presence

45

56.25

14

31

  

Perineural invasion

      

Absence

31

38.75

14

17

0.2609

0.6095

Presence

49

61.25

25

24

  

Tumor invasion

      

T1-2

36

45

24

12

8.41

0.0037**

T3-4

44

55

15

29

  

Lymph node metastasis

      

N0-1

40

50

25

15

6.054

0.0139*

N2-3

40

50

14

26

  

TNM stage

      

I/II

38

47.5

14

24

4.108

0.0427*

III

42

52.5

25

17

  

CEA, ng/ml

      

< 5

44

55

24

20

1.314

0.2516

≥ 5

36

45

15

21

  

Preoperative CTCs status

      

Negative

34

42.5

23

11

8.451

0.0036**

Positive

46

57.5

16

30

  
  1. Abbreviations: CEA, carcinoembryonic antigen; CTCs, circulating tumour cell; TNM, tumour-node-metastasis. *P < 0.05, **P < 0.01
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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