Fig. 5
The impact of targeting glutamine metabolism on the tumor immune microenvironment via three distinct avenues: glutamine antimetabolites, inhibitors of glutamine catabolic-related enzymes, and blockers of glutamine uptake. Red solid T arrows direct inhibitory interactions. Created with BioRender.com. GLS, glutaminase; GPT, glutamate pyruvate transaminase; GOT, glutamic-oxaloacetic transaminase; GLUD, glutamate dehydrogenase; CTLs, cytotoxic T lymphocytes; TCA, tricarboxylic acid; TME, tumor microenvironment; AOA: amino-oxyacetic acid