Fig. 7

Correlation of KLF7 and IGF2BP2 expression in HNSCC and its clinical significance. A Representative immunohistochemical staining images of IGF2BP2 and KLF7 expression in HNSCC tissues. B Correlation analysis of IGF2BP2 and KLF7 expression in 109 HNSCC tissues; C-F Histological scoring of KLF7 in 109 HNSCC tissues with patients' T-stage (C), clinical stage (D), CLN metastasis (E), and pathological grade (F). G and H Kaplan–Meier survival curves of 5-year overall survival (G) and 5-year disease-free survival (H) based on patients with HNSCC with high and low KLF7 expression. I and J Kaplan–Meier survival curves of 5-year OS (I) and 5-year DFS (J) of patients in the high and low KLF7 expression groups combined with IGF2BP2. K Mechanistic model of KLF7-regulated SE-driven IGF2BP2 overexpression promoting malignant progression in HNSCC. *P < 0.05, **P < 0.01, ***P < 0.001. All the data are presented as mean ± SD from three independently performed experiments