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Table 3 Patients’ characteristics

From: TRF2 as novel marker of tumor response to taxane-based therapy: from mechanistic insight to clinical implication

Parameter

N (%)

N° of patients 

49 

Age at diagnosis (years) 

Median (min-max) 

49 (29-76) 

Menopausal status

24 (49.0)

HER2 status

0

41 (83.7)

1+

6 (12.2)

2+SISHa/FISHb not amplified

2 (4.1)

Chemotherapy Regimens

Antracycline+Taxanes

33 (67.3)

Antracylcine+Taxanes+Carboplatinum

16 (32.7)

TRF2 IRS c categories

TRF2Low

12 (24.5)

TRF2High

37 (75.5)

Ki-67 pre neo-adjuvant

Median (min-max) in %

60 (12-95)

pCRd

Yes

18 (36.7)

No

31 (63.3)

Median duration of chemotherapy(months)

5 (2*-8)

Progressive patients

12 (25.0)

No progressive patients

36 (75.0)

Overall Survival

Death

8 (16.7)

Alive

40 (83.3)

  1. aSISH Silver in situ hybridization
  2. bFISH Fluorescence in situ hybridization
  3. cIRS Immunoreactive score
  4. dpCR Pathological complete response