Fig. 3
Knockdown of circRYK inhibits GBM growth in vivo. (A-C) Bioluminescence pictures of brain tumors were taken weekly in nude mice after the precise implantation of glioma cells. Each group consisted of 10 animals. (D) Immunohistochemistry was used to evaluate the shCONT and shcircRYK xenograft tumours. (E) Kaplan‒Meier analysis of survival data showed that shcircRYK mice survived shCONT. Scale bar, 100 μm. Each experiment was performed three times, and the results are displayed as the mean ± SD (*P < 0.05, ***P < 0.001, ****P < 0.0001)