Fig. 4

Platelets are constitutive components of the microenvironment of AT-3 mammary tumors. Representative images of GPIX and collagen IV staining in AT-3 tumors showing the presence of platelets with different types of interactions with tumors: intravascular platelets (1), perivascular platelets (2, 3), abundance of extravascular platelet clusters not associated with hemorrhagic areas (4, 5). White boxes show higher magnification of GPIX-positive platelets