Fig. 5

Platelets are constitutive components of the microenvironment of B16F1 melanoma. Representative images of GPIX and collagen IV staining in B16F1 tumors showing the presence of platelets with different types of interactions with tumors: isolated intravascular platelets (2,3) or intravascular platelet aggregates (4) as well as the presence of extravascular platelets systematically in association with red blood cells (1). White boxes show higher magnification of GPIX-positive platelets