Fig. 3

Gene expression and GSEA analysis of IL6 in TCGA HNSCC cohorts. A Differential analysis of IL6 expression between HPV − and HPV + HNSCC cohorts using TCGA dataset. B DEGs stratified by IL6 high and low expression in HPV − HNSCC cohort. C Expression correlation analysis between IL6 and the top nine upregulated DEGs identified in the IL6 high-expression group. D Pathway enrichment analysis (IL6 high expression vs IL6 low expression) revealing the ‘natural killer cell mediated cytotoxicity’ pathway in TCGA HPV − HNSCC cohort. E Correlation between the expression of IL6 and the other 4 DEGs upregulated in HPV − HNSCC cells vs HPV + HNSCC cells. F Correlation analysis of the gene expression between IL6 and CCR2 in TCGA HPV − HNSCC cohorts