Fig. 4
Blocking IL6 signaling induces the remission of HPV − tumors in orthotopic tumor mouse models. A IL6 concentration in the peripheral serum of C57BL/6 mice bearing MOC2 or TC-1 tumors. B Schematic showing the timeline of experimental procedures. Male C57BL/6 mice at 6–8 weeks of age received intramucosal injection of 1.0 × 106 MOC2 or TC-1 cells. When tumors were established (10 days after cell inoculation), mice were randomized to receive the treatment of IgG2 isotype or αIL6 (100 µg/mouse) (n = 5/group). C, D MOC2 tumor growth curve and weight in each treatment group. E, F TC-1 tumor growth curve and weight in each treatment group. In (C) and (E), representative tumors from C57BL/6 mice with indicated treatment are shown in the upper panel. *p < 0.05; ns: not significant