Fig. 8

A proposed model for this study. A In the microenvironment of HPV − HNSCC, IL6/IL6R and CCL2/CCR2 signaling exert a significant influence on the ability of HPV − tumor cells to evade immune attacks by NK cells. B Simultaneous blockade of IL6/IL6R and CCL2/CCR2 with αIL6 and RS504393 is effective in enhancing the antitumor activity of NK cells in HPV − HNSCC