Oncolytic adenovirus encoding apolipoprotein A1 suppresses metastasis of triple-negative breast cancer in mice

Table 2 Serum biochemistry profiles of adult Rhesus monkeys after ADV-ApoA1 injection

	Control male (n = 6) female (n = 6)	5 × 10¹² VP/Kg (DRF-I.H.) male (n = 1) female (n = 1)	2.4 × 10¹¹ VP/Kg (DRF-I.V.) male (n = 1) female (n = 1)	1 × 10¹³ VP/Kg (MTD-I.H.) male (n = 1) female (n = 1)	1 × 10¹³ VP/Kg (MTD-I.V.) male (n = 1) female (n = 1)
ALT (U/L)	33.6 ± 13.6	31.0 ± 23.0	19.0 ± 5.0	32.0 ± 2.0	125.0 ± 16.0^*
AST (U/L)	50.1 ± 20.1	50.0 ± 5.0	33.5 ± 0.5	41.5 ± 5.5	70.0 ± 26.0
ALP (U/L)	647.2 ± 214.7	424.0 ± 81.0	803.0 ± 60.0	575.0 ± 14.0	468.5 ± 5.5
CK (U/L)	1036.7 ± 1776.3	1267.0 ± 1112.0	219.0 ± 96.0	452.0 ± 175.0	244.5 ± 104.5
LDH (U/L)	597.9 ± 257.9	689.0 ± 54.0	541.5 ± 33.5	512.0 ± 201.0	571.5 ± 180.5
AMY (U/L)	610.5 ± 145.0	689.2 ± 97.2	615.0 ± 111.9	419.7 ± 22.0	532.6 ± 44.9
LIP (U/L)	27.4 ± 22.0	54.0 ± 38.4	16.5 ± 3.7	18.1 ± 3.8	30.2 ± 3.7
BUN (mmol/L)	7.3 ± 1.7	6.9 ± 1.2	6.3 ± 2.0	6.3 ± 0.1	7.6 ± 1.4
CREA (mmol/L)	46.5 ± 6.9	46.0 ± 3.0	44.0 ± 5.0	47.5 ± 7.5	51.0 ± 4.0
GLU (mmol/L)	4.9 ± 0.6	4.7 ± 0.4	4.6 ± 0.3	4.1 ± 0.2	4.8 ± 0.2

I.H., hypodermic injection; I.V., intravenous injection. DRF, dose range finding (12-Day course of 10 viral injections); MTD, maximum tolerated dose (1 viral injection). ALT, alanine amiotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; CK, creatine kinase; LDH, lactate dehydrogenase; AMY, serum amylase; LIP, lipase; BUN, blood urea nitrogen; CREA, creatinine; GLU, glucose. ^*P < 0.05, compared with that in untreated group

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