Table 4 The chromatin remodeling disorder of CSCs in distinct cancers
Cancer types | The measures taken to target chromatin remodeling | Dysregulation in cancer | Effects generated on CSCs and tumors |
|---|---|---|---|
Prostate cancer | utilize oncogenic MUC1-C protein to activate BAF complex | induce NANOG expression and drive Notch signal | promote CSC stemness and tumor progression [159] |
HNSCC | aided by ZSCAN4 induction to facilitate chromatin remodeling | lead to a functional histone 3 hyperacetylation at the promoters of OCT3/4 and NANOG | maintain CSC phenotype and increase CSC frequency [160] |
TNBC | utilize oncogenic MUC1-C protein to promote chromatin remodeling | induce the expression of OCT4, SOX2, KLF4 and MYC | drive the state and stemness of CSC [161] |