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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening

Fig. 1

B7-H3/CD276 is highly expressed in GBM. A The mRNA expression levels of B7-H3/CD276 in normal brain tissues and glioma patient samples of various grades. Data were obtained from the TCGA and CGGA databases. B The Kaplan–Meier curves for overall survival (OS) of glioma patients with high and low expression levels of B7-H3/CD276. Data were obtained from the TCGA and CGGA databases. C Immunohistochemical analysis of B7-H3 expression in different grades of glioma samples. D Cell surface levels of B7-H3 in three human GBM cell lines stained with the B7-H3-PE antibody as measured by flow cytometry. E&F Quantifications of the percentage of B7-H3+ cells (E) and mean fluorescence intensity (MFI) of B7-H3 staining signal (F)

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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