Fig. 7

Efficacy of iBET151 on A549 p60AmotL2-expressing cells in 3D gels. A and B Dose‒response viability testing of A549 cells with CTG after 72 h of treatment with iBET151. Cells were grown in either 2D (A) or 3D Matrigel (B). The IC50 values were calculated using the dose‒response nonlinear regression model from GraphPad Prism. The percentage of viability for p60AmotL2-expressing cells is represented by the blue line and is compared to control cells. From top to bottom, 95% CI for A: [10.39, 16.00] and [5.270, 6.647]; B: [38.92, 63.63] and [4.214, 5.917]; C: [15.74, 23.01] and [12.22, 15.20]; D: [35.59, 86.75] and [7.060, 16.28]. Data represent the mean ± SEM from three independent experiments