Fig. 2
Silencing the METTL3 gene inhibited the proliferation, invasion, and migration abilities of CRC cells while promoting apoptosis. a Representative images and quantitative analysis of CRC cell migration based on wound healing assay. b Decreased expression of METTL3 restrained CRC cell invasion ability based on transwell assay. c The colony formation ability of CRC cells silencing METTL3 or not was measured by colony formation assay. d EDU assay in CRC cells was performed the to measure the proliferation level. e CCK-8 assay was applied to measure the proliferation level of CRC cells after transfected with sh-METTL3 or not. f Flow cytometry analysis the proportion of apoptosis. g Western blotting analysis was applied to measure the protein expression level of E-cadherin, METTL3, SNAIL and Vimentin. GAPDH was used as a loading control. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001