Fig. 3

Decreased expression of METTL3 inhibits tumor growth in vivo. a Comparison of subcutaneous tumor size in nude mice after injecting RKO/SW480 CRC cells stably transfected with Sh-NC/Sh-METTL3. b The tail vein-lung metastasis model. Cells were injected into the tail vein to produce tumor cell lung metastasis. c-d IHC analysis of METTL3, SNAIL and Vimentin for tissues of subcutaneous tumor and lung metastasis tumor. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001