Fig. 2
Development of the LM.SIG. tSNE plot of malignant cells from SKCM (A) and BCC (C). tSNE plots in the right panel revealed the distribution of the GSVA score of LM-related gene sets (LM score). Boxplot depicting the distribution of the LM score in NR and R/TN patients from SKCM (B) and BCC (D). (E) Circos plot depicting the development of LM.SIG. The outer circle represents the enrolled 40 pan-cancer scRNA-seq datasets. The middle circle represents the veen plot depicting the intersection of LMx (blue) and LMy (brown). LMx represents genes positively correlated with LM and LMy represents genes upregulated in malignant cells. The inner circle represents LMn. The final LM.SIG was established based on the geometric mean of Spearman’s correlation coefficient (R) computed for individual genes spanning LM1–LM40. Pathway enrichment analysis of LM.SIG based on Rectome (F), GO (G) and KEGG (H) databases. (ns, not significant; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)