Fig. 4

Immunotherapy response prediction of LM.SIG. (A) Flow chart of training, validating, and testing the LM.SIG model constructed via ML algorithms. (B) Comparison of multiple ROC plots depicting the performance of different ML algorithms in the validation set. ROC plot depicting the performance of the LM.SIG model in validation (C) and testing (D) cohort. Kaplan‑Meier curves comparing OS between High‑risk and Low‑risk patients in validation (E) and testing set (F). NR and R predicted by the LM.SIG model was defined as High‑risk and Low‑risk patients respectively. (G) Circos plot depicting the performance of other pan‑cancer signatures in the testing set. (H) Heatmap comparing the predictive value of LM.SIG and other pan‑cancer signatures