Journal of Experimental & Clinical Cancer Research

Featured Article: Fate of Antibody-Drug Conjugates in Cancer Cells

New Content Item Antibody-Drug Conjugates (ADCs) are composed of an engineered antibody that has been chemically linked to a cytotoxic drug to form a single molecular structure. This combination of antigen specificity and potent cytotoxicity has caused ADCs to be an emerging topic in the field of cancer therapeutics.

In this review, C. Chalouni and S. Doll discuss the mechanisms involved that enable ADCs to trigger the death of tumor cells and how they can be potentially used in future therapeutic strategies for cancer.

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Click here to access all of the reviews published to date in Journal of Experimental & Clinical Cancer Research.

Aims and scope

Journal of Experimental & Clinical Cancer Research is an online peer-reviewed journal that provides a high-quality forum for all aspects of basic, clinical and translational work in oncology.

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Content type: Research
| 17 April 2018

Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene

Authors: Duarte Mendes Oliveira, Katia Grillone, Chiara Mignogna, Valentina De Falco, Carmelo Laudanna, Flavia Biamonte, Rosa Locane, Francesco Corcione, Massimiliano Fabozzi, Rosario Sacco, Giuseppe Viglietto, Donatella Malanga and Antonia Rizzuto
Content type: Research
| 17 April 2018

The CXCL5/CXCR2 axis contributes to the epithelial-mesenchymal transition of nasopharyngeal carcinoma cells by activating ERK/GSK-3β/snail signalling

Authors: Wen-Ze Qiu, Hai-Bo Zhang, Wei-Xiong Xia, Liang-Ru Ke, Jing Yang, Ya-Hui Yu, Hu Liang, Xin-Jun Huang, Guo-Ying Liu, Wang-Zhong Li, Yan-Qun Xiang, Tie-Bang Kang, Xiang Guo and Xing Lv
Content type: Research
| 16 April 2018

MiR-760 suppresses human colorectal cancer growth by targeting BATF3/AP-1/cyclinD1 signaling

Authors: Ling Cao, Yulin Liu, Dan Wang, Lan Huang, Feng Li, Jinbo Liu, Chaoqi Zhang, Zhibo Shen, Qun Gao, Weitang Yuan and Yi Zhang
Content type: Research
| 13 April 2018

The phospholipase DDHD1 as a new target in colorectal cancer therapy

Authors: Stefania Raimondo, Marta Cristaldi, Simona Fontana, Laura Saieva, Francesca Monteleone, Giovanna Calabrese, Gianluca Giavaresi, Rosalba Parenti and Riccardo Alessandro
Content type: Research
| 11 April 2018

SP1-induced upregulation of lncRNA SPRY4-IT1 exerts oncogenic properties by scaffolding EZH2/LSD1/DNMT1 and sponging miR-101-3p in cholangiocarcinoma

Authors: Yi Xu, Yue Yao, Xingming Jiang, Xiangyu Zhong, Zhidong Wang, Chunlong Li, Pengcheng Kang, Kaiming Leng, Daolin Ji, Zhenglong Li, Lining Huang, Wei Qin and Yunfu Cui

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Content type: Review
| 26 September 2011

Apoptosis in cancer: from pathogenesis to treatment

Authors: Rebecca SY Wong
Content type: Review
| 6 October 2015

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

Authors: Go J. Yoshida
Content type: Research
| 3 February 2016

HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer

Authors: Jian Yang, Xu Zhang, Yi Zhang, Dongming Zhu, Lifeng Zhang, Ye Li, Yanbo Zhu, Dechun Li and Jian Zhou
Content type: Research
| 14 September 2009

Characterization of human breast cancer epithelial cells (HBCEC) derived from long term cultured biopsies

Authors: Ralf Hass and Catharina Bertram
Content type: Research article
| 5 February 2015

Elevated kinesin family member 26B is a prognostic biomarker and a potential therapeutic target for colorectal cancer

Authors: Jingtao Wang, Feifei Cui, Xiao Wang, Yingming Xue, Jian Chen, Yang Yu, Huijun Lu, Meng Zhang, Huamei Tang and Zhihai Peng

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Meeting reports now accepted

Journal of Experimental & Clinical Cancer Research now welcomes the submission of Meeting reports to help showcase novel developments presented at meetings and conferences.

Please click here for more information on the article types accepted by Journal of Experimental & Clinical Cancer Research.

Editor-in-Chief

Mauro Castelli, Regina Elena National Cancer Institute, Italy

If you would like to contact Journal of Experimental & Clinical Cancer Research, please send an email to:

jeccreditorial@gmail.com

Call for papers: Translational oncology

We are pleased to announce that a number of BioMed Central journals have come together to create a new cross-journal series on translational oncology.

Guest Edited by Prof Tommaso Dragani (Fondazione IRCCS Istituto Nazionale dei Tumori, Italy), the series is now accepting submissions of research articles that provide important developments in cancer research. Preclinical studies should provide a significant advance in knowledge, and have clear potential for strong clinical impact. For more information on the series, please click here to visit the series page.

Archival content

Journal of Experimental & Clinical Cancer Research has been publishing since 1982. Prior to publishing with BioMed Central from 2008, Journal of Experimental & Clinical Cancer Research was published in print. For enquiries about previous content, please contact us on:

jeccreditorial@gmail.com

Reviewer Acknowledgement

The editorial team of Journal of Experimental & Clinical Cancer Research would like to thank all of our reviewers who have contributed to the journal.

Click here to visit the Reviewer acknowledgements page.

Journal of Experimental & Clinical Cancer Research

Featured Article: Fate of Antibody-Drug Conjugates in Cancer Cells

Aims and scope

Articles

Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene

The CXCL5/CXCR2 axis contributes to the epithelial-mesenchymal transition of nasopharyngeal carcinoma cells by activating ERK/GSK-3β/snail signalling

MiR-760 suppresses human colorectal cancer growth by targeting BATF3/AP-1/cyclinD1 signaling

The phospholipase DDHD1 as a new target in colorectal cancer therapy

SP1-induced upregulation of lncRNA SPRY4-IT1 exerts oncogenic properties by scaffolding EZH2/LSD1/DNMT1 and sponging miR-101-3p in cholangiocarcinoma

Apoptosis in cancer: from pathogenesis to treatment

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer

Characterization of human breast cancer epithelial cells (HBCEC) derived from long term cultured biopsies

Elevated kinesin family member 26B is a prognostic biomarker and a potential therapeutic target for colorectal cancer

Meeting reports now accepted

Editor-in-Chief

Call for papers: Translational oncology

Archival content

Reviewer Acknowledgement

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