Journal of Experimental & Clinical Cancer Research

Featured Review: Proteolysis targeting chimeras (PROTACs) in cancer therapy

New Content Item Exploitation of the protein degradation machinery as a therapeutic strategy to degrade oncogenic proteins is experiencing revolutionary advances with the development of proteolysis targeting chimeras (PROTACs). PROTACs are heterobifunctional structures consisting of a ligand that binds a protein to be degraded and a ligand for an E3 ubiquitin ligase. The bridging between the protein of interest and the E3 ligase mediated by the PROTAC facilitates ubiquitination of the protein and its proteasomal degradation.

In this review, we discuss the molecular medicine behind PROTAC mechanism of action, with special emphasis on recent developments and their potential translation to the clinical setting.

Click here to access all of the reviews published to date in Journal of Experimental & Clinical Cancer Research.

Aims and scope

Journal of Experimental & Clinical Cancer Research is an online peer-reviewed journal that provides a high-quality forum for all aspects of basic, clinical and translational work in oncology.

Please click here to read more.

Editor-in-Chief

Mauro Castelli, Regina Elena National Cancer Institute, Italy

If you would like to contact Journal of Experimental & Clinical Cancer Research, please send an email to:

editorialjeccr@gmail.com

RETSAT associates with DDX39B to promote fork restarting and resistance to gemcitabine based chemotherapy in pancreatic ductal adenocarcinoma

Authors: Qiu Tu, Xiuyun Liu, Xiaoqing Yao, Ruixue Li, Gaojing Liu, Honglv Jiang, Kaiqin Li, Qiongfang Chen, Xiaoyan Huang, Qing Chang, Guoqiang Xu, Hong Zhu, Peng Shi and Bo Zhao

Content type: Research 15 September 2022
Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP

Authors: Mattia La Torre, Chiara Merigliano, Klizia Maccaroni, Alexandre Chojnowski, Wah Ing Goh, Maria Giubettini, Fiammetta Vernì, Cristina Capanni, Daniela Rhodes, Graham Wright, Brian Burke, Silvia Soddu, Romina Burla and Isabella Saggio

Content type: Research 13 September 2022
Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy

Authors: Peijie Zheng, Chuntao Zhou, Liuyi Lu, Bin Liu and Yuemin Ding

Content type: Review 12 September 2022
Long noncoding RNA LINC01132 enhances immunosuppression and therapy resistance via NRF1/DPP4 axis in hepatocellular carcinoma

Authors: Jiwei Zhang, Tao Pan, Weiwei Zhou, Ya Zhang, Gang Xu, Qi Xu, Si Li, Yueying Gao, Zhengtao Wang, Juan Xu and Yongsheng Li

Content type: Research 8 September 2022
The role of DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy

Authors: Congqi Shi, Kaiyu Qin, Anqi Lin, Aimin Jiang, Quan Cheng, Zaoqu Liu, Jian Zhang and Peng Luo

Content type: Review 7 September 2022

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Apoptosis in cancer: from pathogenesis to treatment

Authors: Rebecca SY Wong

Content type: Review 26 September 2011
Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway

Authors: Lu Jiang, Pan Wang, Ying-Jian Sun and Yi-Jun Wu

Content type: Research 18 June 2019
Effects of short-term fasting on cancer treatment

Authors: Stefanie de Groot, Hanno Pijl, Jacobus J. M. van der Hoeven and Judith R. Kroep

Content type: Review 22 May 2019
Health-related quality of life in breast cancer patients: A bibliographic review of the literature from 1974 to 2007

Authors: Ali Montazeri

Content type: Review 29 August 2008
Characterization of human breast cancer epithelial cells (HBCEC) derived from long term cultured biopsies

Authors: Ralf Hass and Catharina Bertram

Content type: Research 14 September 2009

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Springer Nature Oncology Portfolio

Discover the range of academic oncology titles at Springer Nature here.

Call for papers: Long non-coding and circular RNAs in the landscape of cancer progression and metastasis

Journal of Experimental & Clinical Cancer Research is delighted to announce a new thematic series focused on:

The role of long non-coding and circular RNAs as potential cancer biomarkers.

The 2022 Special Issue will accept Research Articles and Reviews regarding the latest highlights on this topic. Submit here.

Submission opens: 1^st January 2022
Submission deadline: 31^st December 2022

Click here to view this collection. Click here to access all thematic series published to date in Journal of Experimental & Clinical Cancer Research.

Call for Papers: Drugging cancer vulnerabilities toward innovative clinical trials

Drugging small Journal of Experimental & Clinical Cancer Research is delighted to announce the new thematic series covering the actual knowledge of novel strategies on anticancer treatments.

The Special Issue will accept Research Articles and Reviews regarding the latest highlights on Drugging cancer vulnerabilities toward innovative clinical trials. Submit here.

Submission opens: 1^st April 2021
Submission deadline: 31^st December 2022

Click here to view this collection. Click here to access all thematic series published to date in Journal of Experimental & Clinical Cancer Research.

Recognising Editorial Excellence

SN Editorial Excellence badge Journal of Experimental & Clinical Cancer Research is a top rated Springer Nature journal. Prof. Mauro Castelli and the editorial team performed in the top percentile of journals based on data collected from the Journal Author Satisfaction Survey. We are recognising extraordinary editors for their commitment and passion to their journals. Read more about editorial excellence here.

Reviewer Acknowledgement and New Recruitment

The Editor-in-Chief of Journal of Experimental & Clinical Cancer Research would like to thank all of our reviewers who have contributed to the journal and is looking for new reviewers to assess manuscripts. For consideration, please send your CV with keywords and expertise to editorialjeccr@gmail.com

Archival content

Journal of Experimental & Clinical Cancer Research has been publishing since 1982. Prior to publishing with BioMed Central from 2008, Journal of Experimental & Clinical Cancer Research was published in print. For enquiries about previous content, please contact us on:

editorialjeccr@gmail.com

Journal of Experimental & Clinical Cancer Research

Featured Review: Proteolysis targeting chimeras (PROTACs) in cancer therapy

Aims and scope

Editor-in-Chief

Articles

RETSAT associates with DDX39B to promote fork restarting and resistance to gemcitabine based chemotherapy in pancreatic ductal adenocarcinoma

Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP

Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy

Long noncoding RNA LINC01132 enhances immunosuppression and therapy resistance via NRF1/DPP4 axis in hepatocellular carcinoma

The role of DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy

Apoptosis in cancer: from pathogenesis to treatment

Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway

Effects of short-term fasting on cancer treatment

Health-related quality of life in breast cancer patients: A bibliographic review of the literature from 1974 to 2007

Characterization of human breast cancer epithelial cells (HBCEC) derived from long term cultured biopsies

Springer Nature Oncology Portfolio

Call for papers: Long non-coding and circular RNAs in the landscape of cancer progression and metastasis

Call for Papers: Drugging cancer vulnerabilities toward innovative clinical trials

Recognising Editorial Excellence

Reviewer Acknowledgement and New Recruitment

Archival content

Annual Journal Metrics

Journal of Experimental & Clinical Cancer Research

Contact us

Featured Review: Proteolysis targeting chimeras (PROTACs) in cancer therapy

Aims and scope

Editor-in-Chief

Articles

Springer Nature Oncology Portfolio

Call for papers: Long non-coding and circular RNAs in the landscape of cancer progression and metastasis

Call for Papers: Drugging cancer vulnerabilities toward innovative clinical trials

Follow JECCR on Social Media

Recognising Editorial Excellence

Reviewer Acknowledgement and New Recruitment

Archival content

Annual Journal Metrics

Journal of Experimental & Clinical Cancer Research

Contact us