Journal of Experimental & Clinical Cancer Research

Featured review: Regulation of PTEN expression by noncoding RNAs

Phosphatase and tensin homologue (PTEN) triggers a battery of intracellular signaling pathways that play important roles in the pathogenesis of multiple diseases, such as cancer and neurodevelopmental disorders. Therefore, targeting the abnormal expression level of PTEN is anticipated to offer novel therapeutic avenues. Noncoding RNAs (ncRNAs) have been reported to regulate PTEN expression epigenetically or posttranscriptionally. In this review, Wang Li et al. present current understandings of the regulation of PTEN by ncRNAs, which could contribute to the development of novel approaches to the diseases with abnormal expression of PTEN.

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Aims and scope

Journal of Experimental & Clinical Cancer Research is an online peer-reviewed journal that provides a high-quality forum for all aspects of basic, clinical and translational work in oncology.

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Editor-in-Chief

Mauro Castelli, Regina Elena National Cancer Institute, Italy

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jeccreditorial@gmail.com

Content type: Research

22 October 2019

A pilot study of alternative TrkAIII splicing in Merkel cell carcinoma: a potential oncogenic mechanism and novel therapeutic target

Authors: Lucia Cappabianca, Stefano Guadagni, Rita Maccarone, Michela Sebastiano, Alessandro Chiominto, Antonietta Rosella Farina and Andrew Reay Mackay
Content type: Research

22 October 2019

Galectin-1 promotes hepatocellular carcinoma and the combined therapeutic effect of OTX008 galectin-1 inhibitor and sorafenib in tumor cells

Authors: Zoe Leung, Frankie Chi Fat Ko, Sze Keong Tey, Ernest Man Lok Kwong, Xiaowen Mao, Bonnie Hei Man Liu, Angel Po Yee Ma, Yi Man Eva Fung, Chi-Ming Che, Danny Ka Ho Wong, Ching Lung Lai, Irene Oi-Lin Ng and Judy Wai Ping Yam
Content type: Research

22 October 2019

A novel BMI-1 inhibitor QW24 for the treatment of stem-like colorectal cancer

Authors: Jinhua Wang, Yajing Xing, Yingying Wang, Yundong He, Liting Wang, Shihong Peng, Lianfang Yang, Jiuqing Xie, Xiaotao Li, Wenwei Qiu, Zhengfang Yi and Mingyao Liu
Content type: Review

21 October 2019

Activity of MCPIP1 RNase in tumor associated processes

Authors: Katarzyna Miekus, Jerzy Kotlinowski, Agata Lichawska-Cieslar, Janusz Rys and Jolanta Jura
Content type: Research

21 October 2019

The Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment

Authors: Ina Patties, Sonja Kallendrusch, Lisa Böhme, Eva Kendzia, Henry Oppermann, Frank Gaunitz, Rolf-Dieter Kortmann and Annegret Glasow

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Content type: Review

26 September 2011

Apoptosis in cancer: from pathogenesis to treatment

Authors: Rebecca SY Wong
Content type: Review

6 October 2015

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

Authors: Go J. Yoshida
Content type: Research

3 February 2016

HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer

Authors: Jian Yang, Xu Zhang, Yi Zhang, Dongming Zhu, Lifeng Zhang, Ye Li, Yanbo Zhu, Dechun Li and Jian Zhou
Content type: Research

14 September 2009

Characterization of human breast cancer epithelial cells (HBCEC) derived from long term cultured biopsies

Authors: Ralf Hass and Catharina Bertram
Content type: Research article

5 February 2015

Elevated kinesin family member 26B is a prognostic biomarker and a potential therapeutic target for colorectal cancer

Authors: Jingtao Wang, Feifei Cui, Xiao Wang, Yingming Xue, Jian Chen, Yang Yu, Huijun Lu, Meng Zhang, Huamei Tang and Zhihai Peng

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Advances in Cancer Immunotherapy

Journal of Experimental & Clinical Cancer Research has published a thematic series on “Advances in Cancer Immunotherapy” to help summarize recent highlights in this field.

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Celebrating the 10th anniversary partnership with BMC

2018 marks the 10^th anniversary of the partnership between the Journal of Experimental & Clinical Cancer Research and BMC.

Over the past decade, the journal has established itself among some of the top Oncology titles in Journal Citation Reports. Click here to look back at some of the journal’s milestone achievements and best content from the past 10 years.

Reviewer Acknowledgement and New Recruitment

The Editor-in-Chief of Journal of Experimental & Clinical Cancer Research would like to thank all of our reviewers who have contributed to the journal and is looking for new reviewers to assess manuscripts. For consideration, please send your CV with keywords and expertise to jeccreditorial@gmail.com

Archival content

Journal of Experimental & Clinical Cancer Research has been publishing since 1982. Prior to publishing with BioMed Central from 2008, Journal of Experimental & Clinical Cancer Research was published in print. For enquiries about previous content, please contact us on:

jeccreditorial@gmail.com

Journal of Experimental & Clinical Cancer Research

Featured review: Regulation of PTEN expression by noncoding RNAs

Aims and scope

Editor-in-Chief

Articles

A pilot study of alternative TrkAIII splicing in Merkel cell carcinoma: a potential oncogenic mechanism and novel therapeutic target

Galectin-1 promotes hepatocellular carcinoma and the combined therapeutic effect of OTX008 galectin-1 inhibitor and sorafenib in tumor cells

A novel BMI-1 inhibitor QW24 for the treatment of stem-like colorectal cancer

Activity of MCPIP1 RNase in tumor associated processes

The Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment

Apoptosis in cancer: from pathogenesis to treatment

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer

Characterization of human breast cancer epithelial cells (HBCEC) derived from long term cultured biopsies

Elevated kinesin family member 26B is a prognostic biomarker and a potential therapeutic target for colorectal cancer

Advances in Cancer Immunotherapy

Celebrating the 10th anniversary partnership with BMC

Reviewer Acknowledgement and New Recruitment

Archival content

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