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Featured review: Regulation of PTEN expression by noncoding RNAs

Regulation of PTEN expression by noncoding RNAsPhosphatase and tensin homologue (PTEN) triggers a battery of intracellular signaling pathways that play important roles in the pathogenesis of multiple diseases, such as cancer and neurodevelopmental disorders. Therefore, targeting the abnormal expression level of PTEN is anticipated to offer novel therapeutic avenues. Noncoding RNAs (ncRNAs) have been reported to regulate PTEN expression epigenetically or posttranscriptionally. In this review, Wang Li et al. present current understandings of the regulation of PTEN by ncRNAs, which could contribute to the development of novel approaches to the diseases with abnormal expression of PTEN.

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Aims and scope

Journal of Experimental & Clinical Cancer Research is an online peer-reviewed journal that provides a high-quality forum for all aspects of basic, clinical and translational work in oncology.

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Mauro Castelli, Regina Elena National Cancer Institute, Italy

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Advances in Cancer Immunotherapy

Advances in Cancer ImmunotherapyJournal of Experimental & Clinical Cancer Research has published a thematic series on “Advances in Cancer Immunotherapy” to help summarize recent highlights in this field. 

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Celebrating the 10th anniversary partnership with BMC

JECCR 10 years​​​​​​​2018 marks the 10th anniversary of the partnership between the Journal of Experimental & Clinical Cancer Research and BMC.

Over the past decade, the journal has established itself among some of the top Oncology titles in Journal Citation Reports. Click here to look back at some of the journal’s milestone achievements and best content from the past 10 years.

Reviewer Acknowledgement and New Recruitment

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The Editor-in-Chief of Journal of Experimental & Clinical Cancer Research would like to thank all of our reviewers who have contributed to the journal and is looking for new reviewers to assess manuscripts. For consideration, please send your CV with keywords and expertise to

Archival content

Journal of Experimental & Clinical Cancer Research has been publishing since 1982.  Prior to publishing with BioMed Central from 2008, Journal of Experimental & Clinical Cancer Research was published in print.  For enquiries about previous content, please contact us on:


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