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Featured Review: Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis

© Caforio et al. (2019)Myc is the most frequent amplified oncogene in human cancers and its alteration is observed in a wide range of tumors, including breast, lung and prostate cancer. The mechanism by which c-Myc exerts its oncogenic functions is not completely clear and different hypothesis are still under investigation. The knowledge of the capacity of c-Myc to bind exclusively E-box sequences determined the discrepancy between genomic studies showing the binding of c-Myc to all active promoters and, on the other hand, the evidence that only 60% or less of the binding sites have E-box sequences.

In this review, Caforio et al. provide support to the hypothesis that the cooperation of c-Myc with transcriptional cofactors mediates c-Myc-induced cellular functions. The authors produce evidence that recently identified cofactors are involved in c-Myc control of survival mechanisms of cancer cells.

Click here to access the full article. 

Click here to access all of the reviews published to date in Journal of Experimental & Clinical Cancer Research.

Aims and scope

Journal of Experimental & Clinical Cancer Research is an online peer-reviewed journal that provides a high-quality forum for all aspects of basic, clinical and translational work in oncology.

Please click here to read more.

Editor-in-Chief

Mauro Castelli, Regina Elena National Cancer Institute, Italy

If you would like to contact Journal of Experimental & Clinical Cancer Research, please send an email to: 

jeccreditorial@gmail.com​​​​​​​

Articles

Call for Papers: Hypoxia and Tumors

Hypoxia and Tumors © royaltystockphoto / FotoliaJournal of Experimental & Clinical Cancer Research is delighted to announce the launch of a new thematic series covering the hot topic of Hypoxia and Tumors.

The Special Issue will accept Research Articles and Reviews regarding the latest highlights on the role of hypoxia in all aspects of tumor progression, including therapy resistance and metastases. Submit here.

Submission opens: 1st December 2019
Submission deadline: 30th June 2020

Click here to view this collection. Click here to access all thematic series published to date in Journal of Experimental & Clinical Cancer Research.

Celebrating the 10th anniversary partnership with BMC

JECCR 10 years​​​​​​​2018 marks the 10th anniversary of the partnership between the Journal of Experimental & Clinical Cancer Research and BMC.

Over the past decade, the journal has established itself among some of the top Oncology titles in Journal Citation Reports. Click here to look back at some of the journal’s milestone achievements and best content from the past 10 years.

Reviewer Acknowledgement and New Recruitment

© Syda Productions / fotolia.com




The Editor-in-Chief of Journal of Experimental & Clinical Cancer Research would like to thank all of our reviewers who have contributed to the journal and is looking for new reviewers to assess manuscripts. For consideration, please send your CV with keywords and expertise to jeccreditorial@gmail.com

Archival content

Journal of Experimental & Clinical Cancer Research has been publishing since 1982.  Prior to publishing with BioMed Central from 2008, Journal of Experimental & Clinical Cancer Research was published in print.  For enquiries about previous content, please contact us on: 

jeccreditorial@gmail.com

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