Skip to main content

Featured Review: RhoC: a fascinating journey from a cytoskeletal organizer to a Cancer stem cell therapeutic target

RhoC Fig 3Tumor heterogeneity results in differential response to therapy due to the existence of plastic tumor cells, called cancer stem cells (CSCs), which exhibit the property of resistance to therapy, invasion and metastasis. RhoC (Ras homolog gene family member C) has been widely reported to regulate actin organization. It has been shown to impact the motility of cancer cells, resultantly affecting invasion and metastasis, and has contributed to carcinoma progression of the breast, pancreas, lung, ovaries and cervix, among several others. The most interesting finding has been its indispensable role in metastasis. These observations suggest that RhoC imparts the plasticity required by tumor cells to exhibit such diverse functions based on microenvironmental cues.

This review throws light on how RhoC, which is capable of modulating various phenotypes may be the apt core signaling candidate regulating disease progression. 

Additionally, mice studies show that RhoC is not essential for embryogenesis, giving scope for its development as a possible therapeutic target. This review thus stresses on the need to understand the protein and its functioning in greater detail to enable its development as a stem cell marker and a possible therapeutic target.

Click here to access all of the reviews published to date in Journal of Experimental & Clinical Cancer Research.

Aims and scope

Journal of Experimental & Clinical Cancer Research is an online peer-reviewed journal that provides a high-quality forum for all aspects of basic, clinical and translational work in oncology.

Please click here to read more.


Mauro Castelli, Regina Elena National Cancer Institute, Italy

If you would like to contact Journal of Experimental & Clinical Cancer Research, please send an email to:​​​​​​​


  1. Authors: Giovanna Carrà, Giuseppe Ermondi, Chiara Riganti, Luisella Righi, Giulia Caron, Alessio Menga, Enrica Capelletto, Beatrice Maffeo, Marcello Francesco Lingua, Federica Fusella, Marco Volante, Riccardo Taulli, Angelo Guerrasio, Silvia Novello, Mara Brancaccio, Rocco Piazza…

    Content type: Research

Call for Papers: Drugging cancer vulnerabilities toward innovative clinical trials

Drugging smallJournal of Experimental & Clinical Cancer Research is delighted to announce the new thematic series covering the actual knowledge of novel strategies on anticancer treatments.

The Special Issue will accept Research Articles and Reviews regarding the latest highlights on Drugging cancer vulnerabilities toward innovative clinical trials. Submit here.

  • Submission opens: 1st April 2021
  • Submission deadline: 31st December 2021

Click here to view this collection. Click here to access all thematic series published to date in Journal of Experimental & Clinical Cancer Research.

Follow JECCR on Social Media

Social Media IconsTwitter



Follow JECCR's social media accounts to be kept up-to-date with the latest articles, collections and journal news!

Recognising Editorial Excellence

SN Editorial Excellence badgeJournal of Experimental & Clinical Cancer Research is a top rated Springer Nature journal. Prof. Mauro Castelli and the editorial team performed in the top percentile of journals based on data collected from the Journal Author Satisfaction Survey. We are recognising extraordinary editors for their commitment and passion to their journals. Read more about editorial excellence here.

Impact of COVID-19 on journal operations

COVID-19As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

We are trying our best to work through this crisis as efficiently and effectively as possible and thank you for your support and patience during these challenging times.

Thumbnail image by Felipe Esquivel Reed, used under Creative Commons Attribution-Share Alike 4.0 license.

Celebrating the 10th anniversary partnership with BMC

JECCR 10 years​​​​​​​2018 marks the 10th anniversary of the partnership between the Journal of Experimental & Clinical Cancer Research and BMC.

Over the past decade, the journal has established itself among some of the top Oncology titles in Journal Citation Reports. Click here to look back at some of the journal’s milestone achievements and best content from the past 10 years.

Reviewer Acknowledgement and New Recruitment

The Editor-in-Chief of Journal of Experimental & Clinical Cancer Research would like to thank all of our reviewers who have contributed to the journal and is looking for new reviewers to assess manuscripts. For consideration, please send your CV with keywords and expertise to

Archival content

Journal of Experimental & Clinical Cancer Research has been publishing since 1982.  Prior to publishing with BioMed Central from 2008, Journal of Experimental & Clinical Cancer Research was published in print.  For enquiries about previous content, please contact us on:

Annual Journal Metrics