Journal of Experimental & Clinical Cancer Research

Featured Review: Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis

© Caforio et al. (2019) Myc is the most frequent amplified oncogene in human cancers and its alteration is observed in a wide range of tumors, including breast, lung and prostate cancer. The mechanism by which c-Myc exerts its oncogenic functions is not completely clear and different hypothesis are still under investigation. The knowledge of the capacity of c-Myc to bind exclusively E-box sequences determined the discrepancy between genomic studies showing the binding of c-Myc to all active promoters and, on the other hand, the evidence that only 60% or less of the binding sites have E-box sequences.

In this review, Caforio et al. provide support to the hypothesis that the cooperation of c-Myc with transcriptional cofactors mediates c-Myc-induced cellular functions. The authors produce evidence that recently identified cofactors are involved in c-Myc control of survival mechanisms of cancer cells.

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Aims and scope

Journal of Experimental & Clinical Cancer Research is an online peer-reviewed journal that provides a high-quality forum for all aspects of basic, clinical and translational work in oncology.

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Editor-in-Chief

Mauro Castelli, Regina Elena National Cancer Institute, Italy

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Overexpressed ITGA2 promotes malignant tumor aggression by up-regulating PD-L1 expression through the activation of the STAT3 signaling pathway

Authors: Dianyun Ren, Jingyuan Zhao, Yan Sun, Dan Li, Zibo Meng, Bo Wang, Ping Fan, Zhiqiang Liu, Xin Jin and Heshui Wu

Content type: Research

9 December 2019
PTPRD-inactivation-induced CXCL8 promotes angiogenesis and metastasis in gastric cancer and is inhibited by metformin

Authors: Won Jung Bae, Ji Mi Ahn, Hye Eun Byeon, Seokwhi Kim and Dakeun Lee

Content type: Research

5 December 2019
NOS1 inhibits the interferon response of cancer cells by S-nitrosylation of HDAC2

Authors: Pengfei Xu, Shuangyan Ye, Keyi Li, Mengqiu Huang, Qianli Wang, Sisi Zeng, Xi Chen, Wenwen Gao, Jianping Chen, Qianbing Zhang, Zhuo Zhong, Ying Lin, Zhili Rong, Yang Xu, Bingtao Hao, Anghui Peng…

Content type: Research

5 December 2019
Discovery, characterization and potential roles of a novel NF-YAx splice variant in human neuroblastoma

Authors: Lucia Cappabianca, Antonietta Rosella Farina, Lucia Di Marcotullio, Paola Infante, Daniele De Simone, Michela Sebastiano and Andrew Reay Mackay

Content type: Research

5 December 2019
Shisa3 brakes resistance to EGFR-TKIs in lung adenocarcinoma by suppressing cancer stem cell properties

Authors: Jiahui Si, Yuanyuan Ma, Ji Wang Bi, Ying Xiong, Chao Lv, Shaolei Li, Nan Wu and Yue Yang

Content type: Research

4 December 2019

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Apoptosis in cancer: from pathogenesis to treatment

Authors: Rebecca SY Wong

Content type: Review

26 September 2011
Metabolic reprogramming: the emerging concept and associated therapeutic strategies

Authors: Go J. Yoshida

Content type: Review

6 October 2015
HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer

Authors: Jian Yang, Xu Zhang, Yi Zhang, Dongming Zhu, Lifeng Zhang, Ye Li, Yanbo Zhu, Dechun Li and Jian Zhou

Content type: Research

3 February 2016
Characterization of human breast cancer epithelial cells (HBCEC) derived from long term cultured biopsies

Authors: Ralf Hass and Catharina Bertram

Content type: Research

14 September 2009
Elevated kinesin family member 26B is a prognostic biomarker and a potential therapeutic target for colorectal cancer

Authors: Jingtao Wang, Feifei Cui, Xiao Wang, Yingming Xue, Jian Chen, Yang Yu, Huijun Lu, Meng Zhang, Huamei Tang and Zhihai Peng

Content type: Research article

5 February 2015

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Call for Papers: Hypoxia and Tumors

Journal of Experimental & Clinical Cancer Research is delighted to announce the launch of a new thematic series covering the hot topic of Hypoxia and Tumors.

The Special Issue will accept Research Articles and Reviews regarding the latest highlights on the role of hypoxia in all aspects of tumor progression, including therapy resistance and metastases. Submit here.

Submission opens: 1^st December 2019
Submission deadline: 30^th June 2020

Click here to view this collection. Click here to access all thematic series published to date in Journal of Experimental & Clinical Cancer Research.

Celebrating the 10th anniversary partnership with BMC

2018 marks the 10^th anniversary of the partnership between the Journal of Experimental & Clinical Cancer Research and BMC.

Over the past decade, the journal has established itself among some of the top Oncology titles in Journal Citation Reports. Click here to look back at some of the journal’s milestone achievements and best content from the past 10 years.

Reviewer Acknowledgement and New Recruitment

The Editor-in-Chief of Journal of Experimental & Clinical Cancer Research would like to thank all of our reviewers who have contributed to the journal and is looking for new reviewers to assess manuscripts. For consideration, please send your CV with keywords and expertise to jeccreditorial@gmail.com

Archival content

Journal of Experimental & Clinical Cancer Research has been publishing since 1982. Prior to publishing with BioMed Central from 2008, Journal of Experimental & Clinical Cancer Research was published in print. For enquiries about previous content, please contact us on:

jeccreditorial@gmail.com

Journal of Experimental & Clinical Cancer Research

Featured Review: Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis

Aims and scope

Editor-in-Chief

Articles

Overexpressed ITGA2 promotes malignant tumor aggression by up-regulating PD-L1 expression through the activation of the STAT3 signaling pathway

PTPRD-inactivation-induced CXCL8 promotes angiogenesis and metastasis in gastric cancer and is inhibited by metformin

NOS1 inhibits the interferon response of cancer cells by S-nitrosylation of HDAC2

Discovery, characterization and potential roles of a novel NF-YAx splice variant in human neuroblastoma

Shisa3 brakes resistance to EGFR-TKIs in lung adenocarcinoma by suppressing cancer stem cell properties

Apoptosis in cancer: from pathogenesis to treatment

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer

Characterization of human breast cancer epithelial cells (HBCEC) derived from long term cultured biopsies

Elevated kinesin family member 26B is a prognostic biomarker and a potential therapeutic target for colorectal cancer

Call for Papers: Hypoxia and Tumors

Celebrating the 10th anniversary partnership with BMC

Reviewer Acknowledgement and New Recruitment

Archival content

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