Journal of Experimental & Clinical Cancer Research

Featured Review: The role of extracelluar matrix in osteosarcoma progression and metastasis

Osteosarcoma (OS) is the most common primary bone malignancy and responsible for considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although neoadjuvant chemotherapy has improved 5-year survival rates for patients with localized OS from 20% to over 65%, outcomes for those with metastasis remain dismal. In addition, therapeutic regimens have not significantly improved patient outcomes over the past four decades, and metastases remains a primary cause of death and obstacle in curative therapy. These limitations in care have given rise to numerous works focused on mechanisms and novel targets of OS pathogenesis, including tumor niche factors. OS is notable for its hallmark production of rich extracellular matrix (ECM) of osteoid that goes beyond simple physiological growth support. The aberrant signaling and structural components of the ECM are rich promoters of OS development, and very recent works have shown the specific pathogenic phenotypes induced by these macromolecules. In this review, the authors summarize the current developments outlining how the ECM contributes to OS progression and metastasis with supporting mechanisms. They also illustrate the potential of tumorigenic ECM elements as prognostic biomarkers and therapeutic targets in the evolving clinical management of OS.

Click here to access all of the reviews published to date in Journal of Experimental & Clinical Cancer Research.

Aims and scope

Journal of Experimental & Clinical Cancer Research is an online peer-reviewed journal that provides a high-quality forum for all aspects of basic, clinical and translational work in oncology.

Please click here to read more.

Editor-in-Chief

Mauro Castelli, Regina Elena National Cancer Institute, Italy

If you would like to contact Journal of Experimental & Clinical Cancer Research, please send an email to:

jeccreditorial@gmail.com

Aberrant miR-874-3p/leptin/EGFR/c-Myc signaling contributes to nasopharyngeal carcinoma pathogenesis

Authors: Sheng-Dean Luo, Hsin-Ting Tsai, Chung-Feng Hwang, Tai‐Jan Chiu, Shau‐Hsuan Li, Ya-Ling Hsu, Chang-Chun Hsiao and Chang-Han Chen

Content type: Research 1 July 2022
Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention

Authors: Sepideh Mirzaei, Mahshid Deldar Abad Paskeh, Elena Okina, Mohammad Hossein Gholami, Kiavash Hushmandi, Mehrdad Hashemi, Azuma Kalu, Ali Zarrabi, Noushin Nabavi, Navid Rabiee, Esmaeel Sharifi, Hassan Karimi-Maleh, Milad Ashrafizadeh, Alan Prem Kumar and Yuzhuo Wang

Content type: Review 1 July 2022
Synaptotagmin 11 scaffolds MKK7–JNK signaling process to promote stem-like molecular subtype gastric cancer oncogenesis

Authors: Bo-Kyung Kim, Da-Mi Kim, Hyunkyung Park, Seon-Kyu Kim, Mi-Aie Hwang, Jungwoon Lee, Mi-Jung Kang, Jae-Eun Byun, Joo-Young Im, Minho Kang, Kyung Chan Park, Young Il Yeom, Seon-Young Kim, Haiyoung Jung, Dae-Hyuk Kweon, Jae-Ho Cheong…

Content type: Research 29 June 2022
PITX2C increases the stemness features of hepatocellular carcinoma cells by up-regulating key developmental factors in liver progenitor

Authors: Lingxi Jiang, Xia Wang, Fangfang Ma, Xuelong Wang, Minmin Shi, Qian Yan, Ming Liu, Juan Chen, Chaoran Shi and Xin-yuan Guan

Content type: Research 28 June 2022
Expanding anti-CD38 immunotherapy for lymphoid malignancies

Authors: Xu Wang, Xinfang Yu, Wei Li, Praveen Neeli, Ming Liu, Ling Li, Mingzhi Zhang, Xiaosheng Fang, Ken H. Young and Yong Li

Content type: Research 28 June 2022

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Apoptosis in cancer: from pathogenesis to treatment

Authors: Rebecca SY Wong

Content type: Review 26 September 2011
Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway

Authors: Lu Jiang, Pan Wang, Ying-Jian Sun and Yi-Jun Wu

Content type: Research 18 June 2019
Health-related quality of life in breast cancer patients: A bibliographic review of the literature from 1974 to 2007

Authors: Ali Montazeri

Content type: Review 29 August 2008
Effects of short-term fasting on cancer treatment

Authors: Stefanie de Groot, Hanno Pijl, Jacobus J. M. van der Hoeven and Judith R. Kroep

Content type: Review 22 May 2019
Characterization of human breast cancer epithelial cells (HBCEC) derived from long term cultured biopsies

Authors: Ralf Hass and Catharina Bertram

Content type: Research 14 September 2009

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Springer Nature Oncology Portfolio

Discover the range of academic oncology titles at Springer Nature here.

Call for papers: Long non-coding and circular RNAs in the landscape of cancer progression and metastasis

Journal of Experimental & Clinical Cancer Research is delighted to announce a new thematic series focused on:

The role of long non-coding and circular RNAs as potential cancer biomarkers.

The 2022 Special Issue will accept Research Articles and Reviews regarding the latest highlights on this topic. Submit here.

Submission opens: 1^st January 2022
Submission deadline: 31^st December 2022

Click here to view this collection. Click here to access all thematic series published to date in Journal of Experimental & Clinical Cancer Research.

Call for Papers: Drugging cancer vulnerabilities toward innovative clinical trials

Drugging small Journal of Experimental & Clinical Cancer Research is delighted to announce the new thematic series covering the actual knowledge of novel strategies on anticancer treatments.

The Special Issue will accept Research Articles and Reviews regarding the latest highlights on Drugging cancer vulnerabilities toward innovative clinical trials. Submit here.

Submission opens: 1^st April 2021
Submission deadline: 30^th June 2022

Click here to view this collection. Click here to access all thematic series published to date in Journal of Experimental & Clinical Cancer Research.

Recognising Editorial Excellence

SN Editorial Excellence badge Journal of Experimental & Clinical Cancer Research is a top rated Springer Nature journal. Prof. Mauro Castelli and the editorial team performed in the top percentile of journals based on data collected from the Journal Author Satisfaction Survey. We are recognising extraordinary editors for their commitment and passion to their journals. Read more about editorial excellence here.

Reviewer Acknowledgement and New Recruitment

The Editor-in-Chief of Journal of Experimental & Clinical Cancer Research would like to thank all of our reviewers who have contributed to the journal and is looking for new reviewers to assess manuscripts. For consideration, please send your CV with keywords and expertise to jeccreditorial@gmail.com

Archival content

Journal of Experimental & Clinical Cancer Research has been publishing since 1982. Prior to publishing with BioMed Central from 2008, Journal of Experimental & Clinical Cancer Research was published in print. For enquiries about previous content, please contact us on:

jeccreditorial@gmail.com

Journal of Experimental & Clinical Cancer Research

Featured Review: The role of extracelluar matrix in osteosarcoma progression and metastasis

Aims and scope

Editor-in-Chief

Articles

Aberrant miR-874-3p/leptin/EGFR/c-Myc signaling contributes to nasopharyngeal carcinoma pathogenesis

Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention

Synaptotagmin 11 scaffolds MKK7–JNK signaling process to promote stem-like molecular subtype gastric cancer oncogenesis

PITX2C increases the stemness features of hepatocellular carcinoma cells by up-regulating key developmental factors in liver progenitor

Expanding anti-CD38 immunotherapy for lymphoid malignancies

Apoptosis in cancer: from pathogenesis to treatment

Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway

Health-related quality of life in breast cancer patients: A bibliographic review of the literature from 1974 to 2007

Effects of short-term fasting on cancer treatment

Characterization of human breast cancer epithelial cells (HBCEC) derived from long term cultured biopsies

Springer Nature Oncology Portfolio

Call for papers: Long non-coding and circular RNAs in the landscape of cancer progression and metastasis

Call for Papers: Drugging cancer vulnerabilities toward innovative clinical trials

Recognising Editorial Excellence

Reviewer Acknowledgement and New Recruitment

Archival content

Annual Journal Metrics

Journal of Experimental & Clinical Cancer Research

Contact us

Featured Review: The role of extracelluar matrix in osteosarcoma progression and metastasis

Aims and scope

Editor-in-Chief

Articles

Springer Nature Oncology Portfolio

Call for papers: Long non-coding and circular RNAs in the landscape of cancer progression and metastasis

Call for Papers: Drugging cancer vulnerabilities toward innovative clinical trials

Follow JECCR on Social Media

Recognising Editorial Excellence

Reviewer Acknowledgement and New Recruitment

Archival content

Annual Journal Metrics

Journal of Experimental & Clinical Cancer Research

Contact us