Journal of Experimental & Clinical Cancer Research

Featured Review: Aspartate β-hydroxylase as a target for cancer therapy

As metastasis is a major cause of death in cancer patients, new anti-metastatic strategies are needed to improve cancer therapy outcomes. Numerous pathways have been shown to contribute to migration and invasion of malignant tumors. Aspartate β-hydroxylase (ASPH) is a key player in the malignant transformation of solid tumors by enhancing cell proliferation, migration, and invasion. ASPH also promotes tumor growth by stimulation of angiogenesis and immunosuppression. These effects are mainly achieved via the activation of Notch and SRC signaling pathways. ASPH expression is upregulated by growth factors and hypoxia in different human tumors and its inactivation may have broad clinical impact. Therefore, small molecule inhibitors of ASPH enzymatic activity have been developed and their anti-metastatic effect confirmed in preclinical mouse models. ASPH can also be targeted by monoclonal antibodies and has also been used as a tumor-associated antigen to induce both cluster of differentiation (CD) 8+ and CD4+ T cells in mice. The PAN-301-1 vaccine against ASPH has already been tested in a phase 1 clinical trial in patients with prostate cancer. In summary, ASPH is a promising target for anti-tumor and anti-metastatic therapy based on inactivation of catalytic activity and/or immunotherapy.

Featured review: Aspartate β-hydroxylase as a target for cancer therapy

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Aims and scope

Journal of Experimental & Clinical Cancer Research is an online peer-reviewed journal that provides a high-quality forum for all aspects of basic, clinical and translational work in oncology.

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Editor-in-Chief

Mauro Castelli, Regina Elena National Cancer Institute, Italy

If you would like to contact Journal of Experimental & Clinical Cancer Research, please send an email to:

jeccreditorial@gmail.com

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Content type: Research 17 May 2022
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Apoptosis in cancer: from pathogenesis to treatment

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Springer Nature Oncology Portfolio

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Call for papers: Long non-coding and circular RNAs in the landscape of cancer progression and metastasis

Journal of Experimental & Clinical Cancer Research is delighted to announce a new thematic series focused on:

The role of long non-coding and circular RNAs as potential cancer biomarkers.

The 2022 Special Issue will accept Research Articles and Reviews regarding the latest highlights on this topic. Submit here.

Submission opens: 1^st January 2022
Submission deadline: 31^st December 2022

Click here to view this collection. Click here to access all thematic series published to date in Journal of Experimental & Clinical Cancer Research.

Call for Papers: Drugging cancer vulnerabilities toward innovative clinical trials

Drugging small Journal of Experimental & Clinical Cancer Research is delighted to announce the new thematic series covering the actual knowledge of novel strategies on anticancer treatments.

The Special Issue will accept Research Articles and Reviews regarding the latest highlights on Drugging cancer vulnerabilities toward innovative clinical trials. Submit here.

Submission opens: 1^st April 2021
Submission deadline: 30^th June 2022

Click here to view this collection. Click here to access all thematic series published to date in Journal of Experimental & Clinical Cancer Research.

Recognising Editorial Excellence

SN Editorial Excellence badge Journal of Experimental & Clinical Cancer Research is a top rated Springer Nature journal. Prof. Mauro Castelli and the editorial team performed in the top percentile of journals based on data collected from the Journal Author Satisfaction Survey. We are recognising extraordinary editors for their commitment and passion to their journals. Read more about editorial excellence here.

Reviewer Acknowledgement and New Recruitment

The Editor-in-Chief of Journal of Experimental & Clinical Cancer Research would like to thank all of our reviewers who have contributed to the journal and is looking for new reviewers to assess manuscripts. For consideration, please send your CV with keywords and expertise to jeccreditorial@gmail.com

Archival content

Journal of Experimental & Clinical Cancer Research has been publishing since 1982. Prior to publishing with BioMed Central from 2008, Journal of Experimental & Clinical Cancer Research was published in print. For enquiries about previous content, please contact us on:

jeccreditorial@gmail.com

Journal of Experimental & Clinical Cancer Research

Featured Review: Aspartate β-hydroxylase as a target for cancer therapy

Aims and scope

Editor-in-Chief

Articles

TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K/AKT pathway in bladder cancer

A positive feedback loop between gastric cancer cells and tumor-associated macrophage induces malignancy progression

GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma

Immunogenomic intertumor heterogeneity across primary and metastatic sites in a patient with lung adenocarcinoma

A novel protein encoded by ZCRB1-induced circHEATR5B suppresses aerobic glycolysis of GBM through phosphorylation of JMJD5

Apoptosis in cancer: from pathogenesis to treatment

Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway

Health-related quality of life in breast cancer patients: A bibliographic review of the literature from 1974 to 2007

Effects of short-term fasting on cancer treatment

Characterization of human breast cancer epithelial cells (HBCEC) derived from long term cultured biopsies

Springer Nature Oncology Portfolio

Call for papers: Long non-coding and circular RNAs in the landscape of cancer progression and metastasis

Call for Papers: Drugging cancer vulnerabilities toward innovative clinical trials

Recognising Editorial Excellence

Reviewer Acknowledgement and New Recruitment

Archival content

Annual Journal Metrics

Journal of Experimental & Clinical Cancer Research

Contact us

Featured Review: Aspartate β-hydroxylase as a target for cancer therapy

Aims and scope

Editor-in-Chief

Articles

Springer Nature Oncology Portfolio

Call for papers: Long non-coding and circular RNAs in the landscape of cancer progression and metastasis

Call for Papers: Drugging cancer vulnerabilities toward innovative clinical trials

Follow JECCR on Social Media

Recognising Editorial Excellence

Reviewer Acknowledgement and New Recruitment

Archival content

Annual Journal Metrics

Journal of Experimental & Clinical Cancer Research

Contact us