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Journal of Experimental & Clinical Cancer Research

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  1. Content type: Research

    Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1) has been recognized as a distinct leukemia entity in the 2016 World Health Organization (WHO) classification. The genetic events underlying oncoge...

    Authors: Hongjun Jin, Liyuan Yang, Lu Wang, Zailin Yang, Qian Zhan, Yao Tao, Qin Zou, Yuting Tang, Jingrong Xian, Shuaishuai Zhang, Yipei Jing and Ling Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:8

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  2. Content type: Research

    Tetrandrine is a bisbenzylisoquinoline alkaloid isolated from the Chinese medicinal herb Stephania tetrandra S. Moore. We previously demonstrated that tetrandrine exhibits potent antitumor effects in many types o...

    Authors: Zhenxing Zhang, Ting Liu, Man Yu, Kangdi Li and Wenhua Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:7

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  3. Content type: Review

    Cancer remains as one of the leading cause of death worldwide. The development of cancer involves an intricate process, wherein many identified and unidentified factors play a role. Although most studies have ...

    Authors: Nyanbol Kuol, Lily Stojanovska, Vasso Apostolopoulos and Kulmira Nurgali

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:5

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  4. Content type: Research

    Stress-Inducible Protein-1 (STIP1) is a co-chaperone that associates directly with heat shock proteins, and regulates motility of various types of cancer. In the present study, we investigated the role of STIP...

    Authors: Linlin Huang, Ertao Zhai, Shirong Cai, Yi Lin, Junbin Liao, Huilin Jin, Sui Peng, Lixia Xu, Minhu Chen and Zhirong Zeng

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:6

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  5. Content type: Research

    Pancreatic stellate cells (PSCs), a major component of the tumor microenvironment in pancreatic cancer, play roles in cancer progression as well as drug resistance. Culturing various cells in microfluidic (mic...

    Authors: Ji-Hyun Lee, Seul-Ki Kim, Iftikhar Ali Khawar, Su-Yeong Jeong, Seok Chung and Hyo-Jeong Kuh

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:4

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  6. Content type: Research

    Recent studies have shown that interferon-γ (IFN-γ)-induced galectin-9 expression in Kupffer cells plays an essential role in modulatingthe microenvironment of hepatitis-associated hepatocellular carcinoma (HC...

    Authors: Shaofei Chen, Jiarui Pu, Jie Bai, Yuping Yin, Ke Wu, Jiliang Wang, Xiaoming Shuai, Jinbo Gao, Kaixiong Tao, Guobin Wang and Hang Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:3

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  7. Content type: Review

    Osteosarcoma (OS) is the most common primary malignant tumor of bone, which preferentially develops lung metastasis. Although standard chemotherapy has significantly improved long-term survival over the past f...

    Authors: Angela De Luca, Lavinia Raimondi, Francesca Salamanna, Valeria Carina, Viviana Costa, Daniele Bellavia, Riccardo Alessandro, Milena Fini and Gianluca Giavaresi

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:2

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  8. Content type: Research

    The receptors of Notch family play an important role in controlling the development, differentiation, and function of multiple cell types. The aim of this study is to investigate the role of Notch1 signaling u...

    Authors: Zike Yang, Yanxia Qi, Nan Lai, Jiahe Zhang, Zehong Chen, Mingyu Liu, Wan Zhang, Rongcheng Luo and Shijun Kang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:1

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  9. Content type: Meeting Report

    In the past decade, the oncology community has witnessed major advances in the understanding of cancer biology and major breakthroughs in several different therapeutic areas, from solid tumors to hematological...

    Authors: Talia Golan, Michele Milella, Aliza Ackerstein and Ranaan Berger

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:192

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  10. Content type: Research

    Golgi Membrane Protein 1 (GOLM1), a protein involved in the trafficking of proteins through the Golgi apparatus, has been shown to be oncogenic in a variety of human cancers. Here, we examined the role of GOLM...

    Authors: Ran Xu, Jianxiong Ji, Xin Zhang, Mingzhi Han, Chao Zhang, Yangyang Xu, Yuzhen Wei, Shuai Wang, Bin Huang, Anjing Chen, Di Zhang, Qing Zhang, Wenjie Li, Zheng Jiang, Jian Wang and Xingang Li

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:193

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  11. Content type: Research

    Patients with gastric cancer commonly have a poor prognosis, owing to its invasiveness and distant metastasis. Recent studies have confirmed the pivotal role of long non-coding RNAs (lncRNAs) in tumorigenesis ...

    Authors: Yanxia Huang, Jing Zhang, Lidan Hou, Ge Wang, Hui Liu, Rui Zhang, Xiaoyu Chen and Jinshui Zhu

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:194

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  12. Content type: Research

    To assess the oncologic outcomes of hypofractionated whole breast irradiation (Hypo-WBI).

    Authors: Paola Pinnarò, Carolina Giordano, Alessia Farneti, Adriana Faiella, Giuseppe Iaccarino, Valeria Landoni, Diana Giannarelli, Patrizia Vici, Lidia Strigari and Giuseppe Sanguineti

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:191

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  13. Content type: Review

    Telomeres are specialized nucleoprotein structures responsible for protecting chromosome ends in order to prevent the loss of genomic information. Telomere maintenance is required for achieving immortality by ...

    Authors: Luca Pompili, Carlo Leonetti, Annamaria Biroccio and Erica Salvati

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:189

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  14. Content type: Research

    Chemoresistance is a major obstacle that limits the benefits of 5-Fluorouracil (5-Fu)-based chemotherapy for colon cancer patients. Autophagy is an important cellular mechanism underlying chemoresistance. Rece...

    Authors: Pan Zhang, Ze-Lin Lai, Hui-Fen Chen, Min Zhang, An Wang, Tao Jia, Wen-Qin Sun, Xi-Min Zhu, Xiao-Feng Chen, Zheng Zhao and Jun Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:190

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  15. Content type: Research

    The nuclear epigenetic integrator UHRF1 is known to play a key role with DNMT1 in maintaining the DNA methylation patterns during cell division. Among UHRF1 partners, TIP60 takes part in epigenetic regulations...

    Authors: Waseem Ashraf, Christian Bronner, Liliyana Zaayter, Tanveer Ahmad, Ludovic Richert, Mahmoud Alhosin, Abdulkhaleg Ibrahim, Ali Hamiche, Yves Mely and Marc Mousli

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:188

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  16. Content type: Research

    Development of resistance to 5-fluorouracil (5-FU) is a major problem in treatment of various cancers including pancreatic cancer. In this study, we reveal important resistance mechanisms and photochemical str...

    Authors: Kaja Lund, Cathrine Elisabeth Olsen, Judith Jing Wen Wong, Petter Angell Olsen, Nina Therese Solberg, Anders Høgset, Stefan Krauss and Pål Kristian Selbo

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:187

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  17. Content type: Review

    Mantle cell lymphoma (MCL) is an aggressive disease, with poor prognosis and a limited survival. However, some patients with indolent MCL can survive beyond 7~10 years. These patients remain largely asymptomat...

    Authors: Haige Ye, Aakash Desai, Dongfeng Zeng, Krystle Nomie, Jorge Romaguera, Makhdum Ahmed and Michael L. Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:185

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  18. Content type: Research

    Gliomas are the most common primary tumors in central nervous system. The prognosis of the patients with glioma is poor regardless of the development of therapeutic strategies. Its aggressive behavior mainly d...

    Authors: Dian-gang Chen, Bo Zhu, Sheng-qing Lv, Hongfan Zhu, Jinliang Tang, Changlin Huang, Qingrui Li, Pu Zhou, Dong-lin Wang and Guang-hui Li

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:186

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  19. Content type: Correction

    In the publication of this article [1], the molecule weight of GPR30 in figures was incorrectly, this should have been 55 kDa, and not 38 kDa.

    Authors: Jing Tian, Yong Wang, Xing Zhang, Qianyao Ren, Rong Li, Yue Huang, Huiling Lu and Jian Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:184

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    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:153

  20. Content type: Research

    Novel therapies tailored to the molecular composition of esophageal squamous cell carcinoma (ESCC) are needed to improve patient survival. We investigated the regulatory network of long intergenic non-protein ...

    Authors: Lianghai Wang, Xiaodan Yu, Zhiyu Zhang, Lijuan Pang, Jiang Xu, Jinfang Jiang, Weihua Liang, Yuhang Chai, Jun Hou and Feng Li

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:182

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  21. Content type: Research

    The early occurrence regional nodal and distant metastases cholangiocarcinoma (CCA) is one of the major reasons for its poor prognosis. However, the related mechanisms are largely elusive. Recently, increasing...

    Authors: Jihua Nie, Jingying Zhang, Lili Wang, Lunjie Lu, Qian Yuan, Fangmei An, Shuyu Zhang and Yang Jiao

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:183

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  22. Content type: Research

    Pancreatic cancer is a lethal disease in part because of its potential for aggressive invasion and metastasis. Lipoxin A4 (LXA4) is one of the metabolites that is derived from arachidonic acid and that is cata...

    Authors: Liang Zong, Ke Chen, Zhengdong Jiang, Xin Chen, Liankang Sun, Jiguang Ma, Cancan Zhou, Qinhong Xu, Wanxing Duan, Liang Han, Jianjun Lei, Xuqi Li, Qingyong Ma and Zheng Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:181

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  23. Content type: Research

    Docetaxel-based chemotherapy failure in advanced prostate carcinoma has partly been attributed to the resistance of prostate cancer (PC) cells to docetaxel-induced apoptosis. Hence, there is an urgent need to ...

    Authors: Zhan Yang, Jin-Suo Chen, Jin-Kun Wen, Hai-Tao Gao, Bin Zheng, Chang-Bao Qu, Kai-Long Liu, Man-Li Zhang, Jun-Fei Gu, Jing-Dong Li, Yan-Ping Zhang, Wei Li, Xiao-Lu Wang and Yong Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:178

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  24. Content type: Research

    A growing amount of evidence has indicated that PSAT1 is an oncogene that plays an important role in cancer progression and metastasis. In this study, we explored the expression and function of PSAT1 in estrog...

    Authors: Song Gao, Anqi Ge, Shouping Xu, Zilong You, Shipeng Ning, Yashuang Zhao and Da Pang

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:179

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  25. Content type: Research

    Accumulating evidence demonstrates that the Urokinase Receptor (uPAR) regulates tumor cell migration through its assembly in composite regulatory units with transmembrane receptors, and uPAR88–92 is the minimal s...

    Authors: Concetta Ragone, Michele Minopoli, Vincenzo Ingangi, Giovanni Botti, Federica Fratangelo, Antonello Pessi, Maria Patrizia Stoppelli, Paolo Antonio Ascierto, Gennaro Ciliberto, Maria Letizia Motti and Maria Vincenza Carriero

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:180

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