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  1. Content type: Research

    Exosomes derived from tumor cells (TEXs) are involved in both immune suppression, angiogenesis, metastasis and anticancer stimulatory, but the biological characteristics and role of diffuse large B cell lympho...

    Authors: Zhenzhen Chen, Liangshun You, Lei Wang, Xianbo Huang, Hui Liu, Ju ying Wei, Li Zhu and Wenbin Qian

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:190

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  2. Content type: Research

    Makorin RING zinc finger-2 (MKRN2) belongs to the makorin RING zinc finger family and is a novel ubiquitin E3 ligase targeting the p65 subunit of NF-κB to negatively regulate inflammatory responses; however, the ...

    Authors: Jun Jiang, Yitong Xu, Hongjiu Ren, Muli Wudu, Qiongzi Wang, Xin Song, Hongbo Su, Xizi Jiang, Lihong Jiang and Xueshan Qiu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:189

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  3. Content type: Research

    Over the last two or three decades, the pace of development of treatments for osteosarcoma tends has been slow. Novel effective therapies for osteosarcoma are still lacking. Previously, we reported that tumor-...

    Authors: Guo-sheng Zhao, Zi-ran Gao, Qiao Zhang, Xue-feng Tang, Yang-fan Lv, Zhao-si Zhang, Yuan Zhang, Qiu-lin Tan, Dong-bin Peng, Dian-ming Jiang and Qiao-Nan Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:188

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  4. Content type: Research

    Gallbladder cancer (GBC) is a highly malignant cancer with poor prognosis. Several long noncoding RNAs (lncRNAs) have been reported to be involved in the tumorigenesis and progression of GBC. However, the expr...

    Authors: Liang Yang, Qingxiang Gao, Xiaoxiong Wu, Feiling Feng and Kaiyun Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:186

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  5. Content type: Research

    Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets of cellular mRNAs. Depletion of PCBP1 is implicated in various carcinomas, but the underlyi...

    Authors: Hongshun Shi, Hui Li, Ronghua Yuan, Wen Guan, Xiaomei Zhang, Shaoyang Zhang, Wenliang Zhang, Fang Tong, Li Li, Zhihong Song, Changwei Wang, Shulan Yang and Haihe Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:187

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  6. Content type: Research

    ANXA2 (Annexin A2) is a pleiotropic calcium-dependent phospholipid binding protein that is abnormally expressed in various cancers. We previously found that ANXA2 is upregulated in esophageal squamous cell car...

    Authors: Sai Ma, Chen-Chen Lu, Li-Yan Yang, Juan-Juan Wang, Bo-Shi Wang, Hong-Qing Cai, Jia-Jie Hao, Xin Xu, Yan Cai, Yu Zhang and Ming-Rong Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:183

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  7. Content type: Research

    Isoliquiritigenin (ISL), a natural flavonoid isolated from the root of licorice (Glycyrrhiza uralensis), has shown various pharmacological properties including anti-oxidant, anti-inflammatory and anti-cancer acti...

    Authors: Shijian Xiang, Huoji Chen, Xiaojun Luo, Baichao An, Wenfeng Wu, Siwei Cao, Shifa Ruan, Zhuxian Wang, Lidong Weng, Hongxia Zhu and Qiang Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:184

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  8. Content type: Research

    Tumor cells transfer into endothelial cells by epithelial–endothelial transition (EET), which is characterized by vasculagenic mimicry (VM) in morphology. VM can change tumor microcirculation, progression, and...

    Authors: Ting Xiao, Qiang Zhang, Shumin Zong, Wei-long Zhong, Yuan Qin, Zhun Bi, Shuang Chen, Hui-juan Liu, Jun-jie Wei, Bi-jiao Zhou, Lu-meng Wang, Hong-gang Zhou, Yan-rong Liu, Tao Sun and Cheng Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:185

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  9. Content type: Research

    Human telomerase reverse transcriptase (hTERT) is highly expressed in over 80% of tumors, including human epithelial ovarian cancer (EOC). However, the mechanisms through which hTERT is up-regulated in EOC and...

    Authors: Yong-Bin Liu, Ying Mei, Jing Long, Yu Zhang, Dong-Li Hu and Hong-Hao Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:182

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  10. Content type: Research

    Glioma is the most common primary central nervous system tumor derived from glial cells. Kininogen-1 (KNG1) can exert antiangiogenic properties and inhibit proliferation of endothelial cells. The effect of KNG...

    Authors: Jinfang Xu, Jun Fang, Zhonghao Cheng, Longlong Fan, Weiwei Hu, Feng Zhou and Hong Shen

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:180

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  11. Content type: Research

    Reprogramming of cancers into normal-like tissues is an innovative strategy for cancer treatment. Recent reports demonstrate that defined factors can reprogram cancer cells into pluripotent stem cells. Gliobla...

    Authors: Jie Yuan, Fan Zhang, Dennis Hallahan, Zhen Zhang, Liming He, Ling-Gang Wu, Meng You and Qin Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:181

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  12. Content type: Research

    In hepatocellular carcinoma (HCC), CD133+/CD44+ cells are one subgroup with high stemness and responsible for metastatic relapse and resistance to treatment. Our previous studies have demonstrated that osteopo...

    Authors: Xiaomei Gao, Yuanyuan Sheng, Jing Yang, Chaoqun Wang, Rui Zhang, Ying Zhu, Ze Zhang, Kaili Zhang, Shican Yan, Haoting Sun, Jinwang Wei, Xuan Wang, Xinxin Yu, Yu Zhang, Qin Luo, Yan Zheng…

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:179

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  13. Content type: Research

    Colorectal cancer (CRC) is a commonly diagnosed digestive malignancy worldwide. Ras-related protein 1A (RAP1A) is a member of the Ras superfamily of small GTPases and has been recently identified as a novel on...

    Authors: Liguo Liu, Xuebing Yan, Dapeng Wu, Yi Yang, Mengcheng Li, Yang Su, Wenchao Yang, Zezhi Shan, Yuping Gao and Zhiming Jin

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:178

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  14. Content type: Research

    Recent studies show that exosomes are involved in intercellular communication and that abundant circular RNAs (circRNAs) are present within exosomes. However, whether these exosomal circRNAs contribute to tumo...

    Authors: Jie Li, Zhonghu Li, Peng Jiang, Minjie Peng, Xi Zhang, Kai Chen, Hui Liu, Huaqiang Bi, Xiangde Liu and Xiaowu Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:177

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  15. Content type: Research

    Adaptation to ER stress has been indicated to play an important role in resistance to therapy in human melanoma. However, the relationship between adaptation to ER stress and cell metastasis in human melanoma ...

    Authors: Dongmei Zhang, Jingrong Lin, Yulin Chao, Lu Zhang, Lei Jin, Na Li, Ruiping He, Binbin Ma, Wenzhi Zhao and Chuanchun Han

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:176

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  16. Content type: Research

    Focal adhesion plays an essential role in tumour invasiveness and metastasis. Hippo component YAP has been widely reported to be involved in many aspects of tumour biology. However, its role in focal adhesion ...

    Authors: Jie Shen, Beibei Cao, Yatao Wang, Chenshen Ma, Zhuo Zeng, Liang Liu, Xiaolan Li, Deding Tao, Jianping Gong and Daxing Xie

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:175

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  17. Content type: Research

    Currently, resistance to tyrosine kinase inhibitors, such as gefitinib, has become a major obstacle in improving the clinical outcome of patients with metastatic and advanced-stage esophageal squamous cell car...

    Authors: Min Kang, Meiping Ren, Yan Li, Yuqiong Fu, Minmin Deng and Changping Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:171

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  18. Content type: Research

    The development of radioresistance is one of main causes for therapeutic failure of prostate cancer (PCa). The present study aims to investigate the function and the related mechanism by which HZ08 sensitizes ...

    Authors: Yanyan Zhang, Zhi Xu, Jiaji Ding, Chunli Tan, Weizi Hu, Yunman Li, Wenlong Huang and Yong Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:174

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  19. Content type: Research

    Accumulating evidences indicate that circular RNAs (circRNAs), a class of non-coding RNAs, play important roles in tumorigenesis. However, the function of circRNAs in hepatocellular cancer (HCC) is largely unk...

    Authors: Ning Bai, Eming Peng, Xingsheng Qiu, Ning Lyu, Zhejia Zhang, Yiming Tao, Xinying Li and Zhiming Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:172

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  20. Content type: Research

    Chronic myelogenous leukemia (CML) is a myeloproliferative disorder caused by expression of the chimeric BCR-ABL tyrosine kinase oncogene, resulting from the t(9;22) chromosomal translocation. Imatinib (gleeve...

    Authors: Francesca Monteleone, Simona Taverna, Riccardo Alessandro and Simona Fontana

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:170

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  21. Content type: Research

    Glioblastoma (GBM) is a primary brain tumor with a 5-year survival rate of ≤5%. We have shown earlier that GBM-antibody-linked curcumin (CC) and also phytosomal curcumin (CCP) rescue 50–60% of GBM-bearing mice...

    Authors: Sumit Mukherjee, Angela Fried, Rahman Hussaini, Richard White, Juliet Baidoo, Sri Yalamanchi and Probal Banerjee

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:168

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  22. Content type: Research

    Increasing studies confirmed that abnormal lncRNAs expression play a critical role in cervical cancer (CC) development and progression. LncRNA TPT1-AS1, a novel lncRNA, its role and underlying mechanisms invol...

    Authors: Hui Jiang, Guanqun Huang, Nianzhang Zhao, Ting Zhang, Mengni Jiang, Yueming He, Xinke Zhou and Xianhan Jiang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:169

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  23. Content type: Research

    Aberrant expression of Wiskott–Aldrich syndrome protein interacting protein family member 1 (WIPF1) contributes to the invasion and metastasis of several malignancies. However, the role of WIPF1 in human pancr...

    Authors: Yu Pan, Fengchun Lu, Ping Xiong, Maoen Pan, Zheyang Zhang, Xianchao Lin, Minggui Pan and Heguang Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:167

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  24. Content type: Research

    The KRAS mutation is the driving force of pancreatic ductal adenocarcinoma (PDAC). Downstream effectors of KRAS signal pathways are crucial to the development of PDAC. The purpose of this study was to investig...

    Authors: Yan Sun, Wenfang Peng, Weiwei He, Man Luo, Guilin Chang, Jiping Shen, Xiaoping Zhao and Yu Hu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:166

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  25. Content type: Research

    Tongue squamous cell carcinoma (TSCC) is the most common oral cancer. Neoadjuvant systemic treatment before or after surgery for advanced TSCC is considered one of the most crucial factors in reducing mortalit...

    Authors: Yixue Gu, Hao Liu, Fangren Kong, Jiahui Ye, Xiaoting Jia, Zhijie Zhang, Nan Li, Jiang Yin, Guopei Zheng and Zhimin He

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:164

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  26. Content type: Research

    Aberrant activation of β-catenin and Yes-associated protein (YAP) signaling pathways has been associated with hepatocellular carcinoma (HCC) progression. The LIM domain protein Ajuba regulates β-catenin and YA...

    Authors: Min Liu, Ke Jiang, Guibin Lin, Peng Liu, Yumei Yan, Tian Ye, Gang Yao, Martin P. Barr, Dapeng Liang, Yang Wang, Peng Gong, Songshu Meng and Haozhe Piao

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:165

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  27. Content type: Research

    Exosomes are critically involved in cancer development and progression. The exosomal contents have been suggested as ideal cancer biomarkers. In this study, we investigated the expression of exosomal proteins ...

    Authors: Hailong Fu, Huan Yang, Xu Zhang, Bo Wang, Jiahui Mao, Xia Li, Mei Wang, Bin Zhang, Zixuan Sun, Hui Qian and Wenrong Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:162

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  28. Content type: Review

    Biomarkers are an integral part of cancer management due to their use in risk assessment, screening, differential diagnosis, prognosis, prediction of response to treatment, and monitoring progress of disease. ...

    Authors: Michelle H. Townsend, Gajendra Shrestha, Richard A. Robison and Kim L. O’Neill

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:163

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  29. Content type: Research

    Oxaliplatin belongs to the platinum-based drug family and has shown promise in treating cancer by binding to DNA to induce cytotoxicity. However, individual patients show diverse therapeutic responses toward o...

    Authors: Huei-Yu Chen, Atikul Islam, Tien-Ming Yuan, Shi-Wen Chen, Pei-Fen Liu and Pin Ju Chueh

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:161

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  30. Content type: Research

    Bone metastasis is a leading cause of morbidity and mortality in advanced prostate cancer (PCa). Downexpression of miR-133a-3p has been found to contribute to the progression, recurrence and distant metastasis...

    Authors: Yubo Tang, Jincheng Pan, Shuai Huang, Xinsheng Peng, Xuenong Zou, Yongxiang Luo, Dong Ren, Xin Zhang, Ronggang Li, Peiheng He and Qingde Wa

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:160

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  31. Content type: Research

    Paired box 8 (PAX8) has been documented to be downregulated in gastric cancer. However, its biological function in this malignancy is poorly understood.

    Authors: Liyan Wang, Xiaotong Bo, Qinghua Zheng, Wenhong Ge, Yanhua Liu and Bin Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:159

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  32. Content type: Research

    Brain invasion by glioblastoma (GBM) determines recurrence and prognosis in patients, which is, in part, attributed to increased mesenchymal transition. Here, we report evidence favoring such a role for the Pr...

    Authors: Xiupeng Xu, Zhongyuan Bao, Yinlong Liu, Kuan Jiang, Tongle Zhi, Dong Wang, Liang Fan, Ning Liu and Jing Ji

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:158

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  33. Content type: Research

    Lycorine has been revealed to inhibit the development of many kinds of malignant tumors, including glioblastoma multiforme (GBM). Although compelling evidences demonstrated Lycorine’s inhibition on cancers thr...

    Authors: Jia Shen, Tao Zhang, Zheng Cheng, Ni Zhu, Hua Wang, Li Lin, Zexia Wang, Haotian Yi and Meichun Hu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:157

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  34. Content type: Research

    Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, pl...

    Authors: Ganlu Deng, Shan Zeng, Yanling Qu, Qingqing Luo, Cao Guo, Ling Yin, Ying Han, Yiyi Li, Changjing Cai, Yaojie Fu and Hong Shen

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:156

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  35. Content type: Research

    Uncontrolled proliferation is thought to be the most fundamental characteristic of cancer. Detailed knowledge of cancer cell proliferation mechanisms would not only benefit understanding of cancer progression,...

    Authors: Mingkun Chen, Rongpei Wu, Gang Li, Cundong Liu, Lei Tan, Kanghua Xiao, Yunlin Ye and Zike Qin

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:154

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  36. Content type: Research

    The poly ADP ribose polymerase (PARP) inhibitor olaparib has been approved for treating prostate cancer (PCa) with BRCA mutations, and veliparib, another PARP inhibitor, is being tested in clinical trials. How...

    Authors: Linglong Yin, Youhong Liu, Yuchong Peng, Yongbo Peng, Xiaohui Yu, Yingxue Gao, Bowen Yuan, Qianling Zhu, Tuoyu Cao, Leye He, Zhicheng Gong, Lunquan Sun, Xuegong Fan and Xiong Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:153

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  37. Content type: Research

    As novel biomarkers for various cancers, microRNAs negatively regulate genes expression via promoting mRNA degradation and suppressing mRNA translation. miR-589 has been reported to be deregulated in several h...

    Authors: Feifei Zhang, Kaitao Li, Mingxin Pan, Weidong Li, Juan Wu, Mingyi Li, Liang Zhao and Hui Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:152

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  38. Content type: Correction

    In the publication of this article [1], there is an error in the Figure caption of Figs. 2, 3 and 4. This has now been included in this correction. The authors declare that these corrections do not change the ...

    Authors: Mei Yi, Junjun Li, Shengnan Chen, Jing Cai, Yuanyuan Ban, Qian Peng, Ying Zhou, Zhaoyang Zeng, Shuping Peng, Xiaoling Li, Wei Xiong, Guiyuan Li and Bo Xiang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:155

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    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:118

  39. Content type: Research

    Exosomes are small vesicles containing a wide range of functional proteins, mRNA and miRNA. Exosomal miRNAs from cancer cells play crucial roles in mediating cell-cell communication and tumor-microenvironment ...

    Authors: Juan Lu, Qi-Hui Liu, Fan Wang, Jia-Jie Tan, Yue-Qin Deng, Xiao-Hong Peng, Xiong Liu, Bao Zhang, Xia Xu and Xiang-Ping Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:147

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  40. Content type: Research

    Colorectal cancer (CRC) is one of the most prevalent malignancies in the world and developed drug resistance has represented one of the most challenging tasks for management. The current therapeutic regimens m...

    Authors: Mao-Hua Cai, Xiao-Gang Xu, Shi-Li Yan, Ze Sun, Yin Ying, Bai-Kui Wang and Yue-Xing Tu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:151

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  41. Content type: Review

    The natural history of mantle cell lymphoma (MCL) is a continuous process with the vicious cycle of remission and recurrence. Because MCL cells are most vulnerable before their exposure to therapeutic agents, ...

    Authors: Haige Ye, Aakash Desai, Shengjian Huang, Dayoung Jung, Richard Champlin, Dongfeng Zeng, Fangfang Yan, Krystle Nomie, Jorge Romaguera, Makhdum Ahmed and Michael L. Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:150

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  42. Content type: Research

    The long non-coding RNAs (lncRNAs) have participated in the promotion of hepatocellular carcinoma (HCC) initiation and progression. Nevertheless, the biological role and underlying mechanism of LINC01287 in HC...

    Authors: Yichao Mo, Longguang He, Zeru Lai, Zhiheng Wan, Qinshou Chen, Sibo Pan, Liangfu Li, Dasheng Li, Junwei Huang, Fan Xue and Siyao Che

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:149

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  43. Content type: Research

    Oral squamous cell carcinoma (OSCC) is one of the most common malignancies and has a poor prognosis. The epithelial-to-mesenchymal transition (EMT) is crucial for increasing the metastasis of OSCC. Recently, s...

    Authors: Wenlu Li, Dandan Zhu and Shuaihua Qin

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:148

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  44. Content type: Research

    The disruption of E-cadherin-mediated adhesion is considered an important driver of tumor progression. Nevertheless, numerous studies have demonstrated that E-cadherin promotes growth- or invasion-related sign...

    Authors: Katia Rea, Francesca Roggiani, Loris De Cecco, Francesco Raspagliesi, Maria Luisa Carcangiu, Joyce Nair-Menon, Marina Bagnoli, Ileana Bortolomai, Delia Mezzanzanica, Silvana Canevari, Antonis Kourtidis, Panos Z. Anastasiadis and Antonella Tomassetti

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:146

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  45. Content type: Research

    Next-generation sequencing of the exome and genome of prostate cancers has identified numerous genetic alterations. SPOP (Speckle-type POZ Protein) is one of the most frequently mutated genes in primary prostate ...

    Authors: Jian Ma, Kun Chang, Jingtao Peng, Qing Shi, Hualei Gan, Kun Gao, Kai Feng, Fujiang Xu, Hailiang Zhang, Bo Dai, Yao Zhu, Guohai Shi, Yijun Shen, Yiping Zhu, Xiaojian Qin, Yao Li…

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:145

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  46. Content type: Research

    Serine/threonine protein kinase 25 (STK25) is critical in regulating whole-body glucose and insulin homeostasis and the accumulation of ectopic lipids. The Warburg effect, also known as aerobic glycolysis, is ...

    Authors: Fan Wu, Pin Gao, Wei Wu, Zaozao Wang, Jie Yang, Jiabo Di, Beihai Jiang and Xiangqian Su

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:144

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  47. Content type: Research

    Mounting evidence suggests that RAF-mediated MEK activation plays a crucial role in paradox MAPK (re)activation, leading to resistance and therapeutic failure with agents hitting a single step along the MAPK c...

    Authors: Anais Del Curatolo, Fabiana Conciatori, Ursula Cesta Incani, Chiara Bazzichetto, Italia Falcone, Vincenzo Corbo, Sabrina D’Agosto, Adriana Eramo, Giovanni Sette, Isabella Sperduti, Teresa De Luca, Mirko Marabese, Senji Shirasawa, Ruggero De Maria, Aldo Scarpa, Massimo Broggini…

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:140

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  48. Content type: Research

    Treatment strategies targeting tumor-associated macrophages (TAMs) have been proposed in cancer areas. The functional alterations of macrophages in the microenvironment during the tumorigenesis of human epithe...

    Authors: Meng Xiao, Jianjun Zhang, Wanjun Chen and Wantao Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:143

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  49. Content type: Research

    Metastasis is the leading cause of cancer mortality and is a major hurdle for lung cancer treatment. Invadopodia, which are cancer-specific protrusive structures, play a crucial role in the metastatic cascade ...

    Authors: Yongwen Li, Hongbing Zhang, Hao Gong, Yin Yuan, Ying Li, Cong Wang, Weiting Li, Zihe Zhang, Minghui Liu, Hongyu Liu and Jun Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:141

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