Owned by the Association for International Promotion & Study in Tumors (APSIT)
Articles
Page 1 of 68
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Citation: Journal of Experimental & Clinical Cancer Research 2023 42:70
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ALDOC- and ENO2- driven glucose metabolism sustains 3D tumor spheroids growth regardless of nutrient environmental conditions: a multi-omics analysis
Metastases are the major cause of cancer-related morbidity and mortality. By the time cancer cells detach from their primary site to eventually spread to distant sites, they need to acquire the ability to surv...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:69 -
CLDN6 inhibits breast cancer metastasis through WIP-dependent actin cytoskeleton-mediated autophagy
As a breast cancer suppressor gene, CLDN6 overexpression was found to inhibit breast cancer metastasis in our previous studies, but the specific mechanism remains unclear. This study aimed to clarify the role ...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:68 -
Guadecitabine increases response to combined anti-CTLA-4 and anti-PD-1 treatment in mouse melanoma in vivo by controlling T-cells, myeloid derived suppressor and NK cells
The combination of Programmed Cell Death 1 (PD-1) and Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) blockade has dramatically improved the overall survival rate for malignant melanoma. Immune checkpoint blockers (...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:67 -
A diagnostic circulating miRNA signature as orchestrator of cell invasion via TKS4/TKS5/EFHD2 modulation in human gliomas
Altered microRNA profiles have been observed not only in tumour tissues but also in biofluids, where they circulate in a stable form thus representing interesting biomarker candidates. This study aimed to iden...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:66 -
METTL3 promotes chemoresistance in small cell lung cancer by inducing mitophagy
Small cell lung cancer (SCLC) is the most aggressive subtype of lung cancer. Although most patients are initially sensitive to first-line combination chemotherapy with cisplatin and etoposide, chemotherapy dru...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:65 -
circMMD reduction following tumor treating fields inhibits glioblastoma progression through FUBP1/FIR/DVL1 and miR-15b-5p/FZD6 signaling
Tumor treating fields (TTF) is the latest treatment for GBM. Circular RNA (circRNA) has been demonstrated to play critical roles in tumorigenesis. However, the molecular mechanism of TTF remained largely unkno...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:64 -
CircFOXK2 promotes hepatocellular carcinoma progression and leads to a poor clinical prognosis via regulating the Warburg effect
The Warburg effect is well-established to be essential for tumor progression and accounts for the poor clinical outcomes of hepatocellular carcinoma (HCC) patients. An increasing body of literature suggests th...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:63 -
Research progress on non-protein-targeted drugs for cancer therapy
Non-protein target drugs, especially RNA-based gene therapies for treating hereditary diseases, have been recognized worldwide. As cancer is an insurmountable challenge, no miracle drug is currently available....
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:62 -
CD46 targeted 212Pb alpha particle radioimmunotherapy for prostate cancer treatment
We recently identified CD46 as a novel prostate cancer cell surface antigen that shows lineage independent expression in both adenocarcinoma and small cell neuroendocrine subtypes of metastatic castration resi...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:61 -
Silencing LCN2 suppresses oral squamous cell carcinoma progression by reducing EGFR signal activation and recycling
EGFR is an important signal involved in tumor growth that can induce tumor metastasis and drug resistance. Exploring targets for effective EGFR regulation is an important topic in current research and drug dev...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:60 -
Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements. Metab...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:59 -
Retraction Note: Long non-coding RNA SLC2A1-AS1 induced by GLI3 promotes aerobic glycolysis and progression in esophageal squamous cell carcinoma by sponging miR-378a-3p to enhance Glut1 expression
This article has been retracted. Please see the Retraction Notice for more detail: https://10.1186/s13046-021-02081-8.
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:58 -
Current advances in understanding the molecular profile of hereditary diffuse gastric cancer and its clinical implications
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome attributed to germline CDH1 mutations that carries a high risk for early onset DGC. HDGC raises a significant health issue due to ...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:57 -
Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer
Colorectal cancer (CRC) can be divided into four consensus molecular subtypes (CMS), each with distinct biological features. CMS4 is associated with epithelial-mesenchymal transition and stromal infiltration (...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:56 -
NAD pool as an antitumor target against cancer stem cells in head and neck cancer
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors that affect different anatomical locations. Despite this heterogeneity, HNSCC treatment depends on the anatomical location, TNM ...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:55 -
Retraction Note: LNCAROD enhances hepatocellular carcinoma malignancy by activating glycolysis through induction of pyruvate kinase isoform PKM2
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-021-02090-7.
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:54 -
Aryl hydrocarbon receptor nuclear translocator limits the recruitment and function of regulatory neutrophils against colorectal cancer by regulating the gut microbiota
Although the role and mechanism of neutrophils in tumors have been widely studied, the precise effects of aryl hydrocarbon receptor nuclear translocator (ARNT) on neutrophils remain unclear. In this study, we ...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:53 -
L-kynurenine induces NK cell loss in gastric cancer microenvironment via promoting ferroptosis
Natural killer (NK) cells play a major role in body’s fighting against various types of cancers. Their infiltration in the tumor microenvironment (TME) of gastric cancer (GC) are significantly decreased, which...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:52 -
Integrative analysis of bulk and single-cell gene expression profiles to identify tumor-associated macrophage-derived CCL18 as a therapeutic target of esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is a common gastrointestinal malignancy with poor patient prognosis. Current treatment for ESCC, including immunotherapy, is only beneficial for a small subset of pati...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:51 -
Beyond lymphopenia, unraveling radiation-induced leucocyte subpopulation kinetics and mechanisms through modeling approaches
Leucocyte subpopulations in both lymphoid and myeloid lineages have a significant impact on antitumor immune response. While radiation-induced lymphopenia is being studied extensively, radiation effects on lym...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:50 -
Water channel protein AQP1 in cytoplasm is a critical factor in breast cancer local invasion
Metastasis of breast cancer grows from the local invasion to the distant colonization. Blocking the local invasion step would be promising for breast cancer treatment. Our present study demonstrated AQP1 was a...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:49 -
Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-𝜅B-IL-6 axis of tumor-associated macrophages
Circular RNAs (circRNAs) have important regulatory functions in cancer, but the role of circRNAs in the tumor microenvironment (TME) remains unclear. Moreover, we also explore the effects of si-circRNAs loaded...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:48 -
Correction: NCSTN promotes hepatocellular carcinoma cell growth and metastasis via β-catenin activation in a Notch1/AKT dependent manner
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:47 -
Exosomal circTUBGCP4 promotes vascular endothelial cell tipping and colorectal cancer metastasis by activating Akt signaling pathway
Exosome is crucial mediator and play an important role in tumor angiogenesis. Tip cell formation is a prerequisite for persistent tumor angiogenesis which causes tumor metastasis. However, the functions and un...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:46 -
Procoxacin bidirectionally inhibits osteoblastic and osteoclastic activity in bone and suppresses bone metastasis of prostate cancer
Bone is the most common site of metastasis of prostate cancer (PCa). PCa invasion leads to a disruption of osteogenic-osteolytic balance and causes abnormal bone formation. The interaction between PCa and bone...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:45 -
The BRD4 inhibitor JQ1 augments the antitumor efficacy of abemaciclib in preclinical models of gastric carcinoma
Advanced gastric cancer (GC) is a lethal malignancy, harboring recurrent alterations in cell cycle pathway, especially the CDKN2A-CDK4/CDK6/CCND1 axis. However, monotherapy of CDK4/6 inhibitors has shown limit...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:44 -
Retraction Note: HnRNP A1 - mediated alternative splicing of CCDC50 contributes to cancer progression of clear cell renal cell carcinoma via ZNF395
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-020-01606-x.
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:43 -
GPX8 regulates clear cell renal cell carcinoma tumorigenesis through promoting lipogenesis by NNMT
Clear cell renal cell carcinoma (ccRCC), with its hallmark phenotype of high cytosolic lipid content, is considered a metabolic cancer. Despite the implication of this lipid-rich phenotype in ccRCC tumorigenes...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:42 -
HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway
The response rate to immunotherapy in patients with bladder cancer (BCa) remains relatively low. Considering the stable existence and important functions in tumour metabolism, the role of circRNAs in regulatin...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:41 -
MiR-455-5p suppresses PDZK1IP1 to promote the motility of oral squamous cell carcinoma and accelerate clinical cancer invasion by regulating partial epithelial-to-mesenchymal transition
Lymph node and distant metastasis contribute to poor outcomes in patients with oral squamous cell carcinoma (OSCC). The mechanisms regulating cancer migration and invasion play a key role in OSCC.
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:40 -
Sunitinib efficacy with minimal toxicity in patient-derived retinoblastoma organoids
Recurrence of retinoblastoma (RB) following chemoreduction is common and is often managed with local (intra-arterial/intravitreal) chemotherapy. However, some tumors are resistant to even local administration ...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:39 -
HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway
Hepatic inflammation is a common initiator of liver diseases and considered as the primary driver of hepatocellular carcinoma (HCC). However, the precise mechanism of inflammation-induced HCC development and i...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:38 -
Patient-derived cell-based pharmacogenomic assessment to unveil underlying resistance mechanisms and novel therapeutics for advanced lung cancer
A pharmacogenomic platform using patient-derived cells (PDCs) was established to identify the underlying resistance mechanisms and tailored treatment for patients with advanced or refractory lung cancer.
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:37 -
Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer
Genetic background plays an important role in the occurrence and development of gastric cancer (GC). With the application of genome-wide association study (GWAS), an increasing number of tumor susceptibility g...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:36 -
Cancer-educated mammary adipose tissue-derived stromal/stem cells in obesity and breast cancer: spatial regulation and function
Breast cancer is the most frequently diagnosed cancer and a common cause of cancer-related death in women. It is well recognized that obesity is associated with an enhanced risk of more aggressive breast cance...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:35 -
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability
Metabolic reprogramming is a hallmark of various cancers. Targeting metabolic processes is a very attractive treatment for cancer. Renal cell carcinoma (RCC) is a type of metabolic disease, and the lipidomic p...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:34 -
LARP6 suppresses colorectal cancer progression through ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis
With increasing incidence and mortality, colorectal cancer (CRC) seriously endangers human health. LARP6, a member of La-related protein (LARP) family, is a RNA binding protein and probably associates with CRC pr...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:33 -
Retraction Note: Hsa_circ_0001944 promotes the growth and metastasis in bladder cancer cells by acting as a competitive endogenous RNA for miR-548
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-020-01697-6.
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:32 -
Retraction Note: M2 macrophage-derived extracellular vesicles promote gastric cancer progression via a microRNA-130b-3p/MLL3/GRHL2 signaling cascade
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-020-01626-7.
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:31 -
Retraction Note: Genistein inhibits stemness of SKOV3 cells induced by macrophages co-cultured with ovarian cancer stem-like cells through IL-8/STAT3 axis
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-018-1010-1.
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:30 -
A flexible liposomal polymer complex as a platform of specific and regulable immune regulation for individual cancer immunotherapy
The applicability and therapeutic efficacy of specific personalized immunotherapy for cancer patients is limited by the genetic diversity of the host or the tumor. Side-effects such as immune-related adverse e...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:29 -
Single-nucleus RNA sequencing and deep tissue proteomics reveal distinct tumour microenvironment in stage-I and II cervical cancer
Cervical cancer (CC) is the 3rd most common cancer in women and the 4th leading cause of deaths in gynaecological malignancies, yet the exact progression of CC is inconclusive, mainly due to the high complexity o...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:28 -
Mesothelioma-associated fibroblasts enhance proliferation and migration of pleural mesothelioma cells via c-Met/PI3K and WNT signaling but do not protect against cisplatin
Pleural mesothelioma (PM) is an aggressive malignancy with poor prognosis. Unlike many other cancers, PM is mostly characterized by inactivation of tumor suppressor genes. Its highly malignant nature in absence o...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:27 -
Long-term exposure to house dust mites accelerates lung cancer development in mice
Individuals with certain chronic inflammatory lung diseases have a higher risk of developing lung cancer (LC). However, the underlying mechanisms remain largely unknown. Here, we hypothesized that chronic expo...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:26 -
Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth
Intrinsic or acquired resistance to HER2-targeted therapy is often a problem when small molecule tyrosine kinase inhibitors or antibodies are used to treat patients with HER2 positive breast cancer. Therefore,...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:25 -
Retraction Note: IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-020-01657-0.
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:24 -
Correction: Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/ Akt signaling pathway in gastric cancer
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:23 -
Repurposing nitric oxide donating drugs in cancer therapy through immune modulation
Nitric oxide-releasing drugs are used for cardiovascular diseases; however, their effects on the tumor immune microenvironment are less clear. Therefore, this study explored the impact of nitric oxide donors o...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:22 -
Stroma-derived miR-214 coordinates tumor dissemination
Tumor progression is based on a close interaction between cancer cells and Tumor MicroEnvironment (TME). Here, we focus on the role that Cancer Associated Fibroblasts (CAFs), Mesenchymal Stem Cells (MSCs) and ...
Citation: Journal of Experimental & Clinical Cancer Research 2023 42:20
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