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  1. Innovative therapies to target tumor-associated neutrophils (PMN) are of clinical interest, since these cells are centrally involved in cancer inflammation and tumor progression. Resolvin D1 (RvD1) is a lipid ...

    Authors: Domenico Mattoscio, Elisa Isopi, Alessia Lamolinara, Sara Patruno, Alessandro Medda, Federica De Cecco, Susanna Chiocca, Manuela Iezzi, Mario Romano and Antonio Recchiuti

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:129

    Content type: Research

    Published on:

  2. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Qian Chen, Xiao-Wei Zhou, Ai-Jun Zhang and Kang He

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:128

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:23

  3. Hepatocellular carcinoma (HCC) is one of the most common malignant cancers worldwide, and liver cancer has increased in mortality due to liver cancer because it was detected at an advanced stages in patients w...

    Authors: Sanghwa Kim, Minji Lee, Yeonhwa Song, Su-Yeon Lee, Inhee Choi, I-Seul Park, Jiho Kim, Jin-sun Kim, Kang mo Kim and Haeng Ran Seo

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:127

    Content type: Research

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  4. NOD-like receptors affect multiple stages of cancer progression in many malignancies. NACHT, LRR, and PYD domain-containing protein 7 (NLRP7) is a member of the NOD-like receptor family, although its role in t...

    Authors: Bing Li, Zhi-Peng Qi, Dong-Li He, Zhang-Han Chen, Jing-Yi Liu, Meng-Wai Wong, Jia-Wei Zhang, En-Pan Xu, Qiang Shi, Shi-Lun Cai, Di Sun, Li-Qing Yao, Ping-Hong Zhou and Yun-Shi Zhong

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:126

    Content type: Research

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  5. Dehydrodiisoeugenol (DEH), a novel lignan component extracted from nutmeg, which is the seed of Myristica fragrans Houtt, displays noticeable anti-inflammatory and anti-allergic effects in digestive system diseas...

    Authors: Changhong Li, Kui Zhang, Guangzhao Pan, Haoyan Ji, Chongyang Li, Xiaowen Wang, Xin Hu, Ruochen Liu, Longfei Deng, Yi Wang, Liqun Yang and Hongjuan Cui

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:125

    Content type: Research

    Published on:

  6. Pancreatic cancer is a malignant tumor and ranks the sixth in incidence among cancers. Circular RNA (circRNA) has been reported to regulate the progression of pancreatic cancer. However, the effects of circ-me...

    Authors: Xiaoxiao Zhou, Kun Liu, Jing Cui, Jiongxin Xiong, Heshui Wu, Tao Peng and Yao Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:124

    Content type: Research

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  7. Long noncoding RNAs (lncRNAs) contribute to multiple biological processes in human glioblastoma (GBM). However, identifying a specific lncRNA target remains a challenge. In this study, bioinformatics methods a...

    Authors: Chen Zhong, Qian Yu, Yucong Peng, Shengjun Zhou, Zhendong Liu, Yong Deng, Leiguang Guo, Shiguang Zhao and Gao Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:123

    Content type: Research

    Published on:

  8. PARP inhibitors (PARPi) benefit only a fraction of breast cancer patients with BRCA mutations, and their efficacy is even more limited in triple-negative breast cancer (TNBC) due to clinical primary and acquir...

    Authors: Xiuzhi Zhu, Li Chen, Binhao Huang, Xiaoguang Li, Liu Yang, Xin Hu, Yizhou Jiang, Zhimin Shao and Zhonghua Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:122

    Content type: Research

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  9. Reprogrammed glucose metabolism, also known as the Warburg effect, which is essential for tumor progression, is regarded as a hallmark of cancer. MAP17, a small 17-kDa non-glycosylated membrane protein, is fre...

    Authors: Fangyuan Dong, Rongkun Li, Jiaofeng Wang, Yan Zhang, Jianfeng Yao, Shu-Heng Jiang, Xiaona Hu, Mingxuan Feng and Zhijun Bao

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:121

    Content type: Research

    Published on:

  10. Not all breast cancer (BC) patients who receive neoadjuvant chemotherapy achieve a pathologic complete response (pCR), but the reasons for this are unknown. Previous studies have shown that exosomes produced i...

    Authors: Qianxi Yang, Shaorong Zhao, Zhendong Shi, Lixia Cao, Jingjing Liu, Teng Pan, Dongdong Zhou and Jin Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:120

    Content type: Research

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  11. The circadian system temporally regulates physiology to maintain homeostasis. Co-opting and disrupting circadian signals appear to be distinct attributes that are functionally important for the development of ...

    Authors: Elizabeth Cash, Sandra Sephton, Cassandra Woolley, Attia M. Elbehi, Anu R. I., Bene Ekine-Afolabi and Victor C. Kok

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:119

    Content type: Review

    Published on:

  12. Hepatoma is a common malignancy of the liver. The abnormal high expression of alpha-fetoprotein (AFP) is intimately associated with hepatoma progress, but the mechanism of transcriptional regulation and singul...

    Authors: Zhengyi Cao, Yuning Cheng, Jiyin Wang, Yujuan Liu, Ruixiang Yang, Wei Jiang, Hui Li and Xiaowei Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:118

    Content type: Research

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  13. The application of immune-based therapies has revolutionized cancer treatment. Yet how the immune system responds to phenotypically heterogeneous populations within tumors is poorly understood. In melanoma, on...

    Authors: Luis Sánchez-del-Campo, Román Martí-Díaz, María F. Montenegro, Rebeca González-Guerrero, Trinidad Hernández-Caselles, Enrique Martínez-Barba, Antonio Piñero-Madrona, Juan Cabezas-Herrera, Colin R. Goding and José Neptuno Rodríguez-López

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:117

    Content type: Research

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  14. High grade serous ovarian cancer (HGSOC) is among the deadliest human cancers and its prognosis remains extremely poor. Tumor heterogeneity and rapid acquisition of resistance to conventional chemotherapeutic ...

    Authors: Camilla Nero, Giuseppe Vizzielli, Domenica Lorusso, Eleonora Cesari, Gennaro Daniele, Matteo Loverro, Giovanni Scambia and Claudio Sette

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:116

    Content type: Review

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  15. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Gangjun Yuan, Xin Chen, Zhuowei Liu, Wensu Wei, Qinghai Shu, Hussein Abou-Hamdan, Lijuan Jiang, Xiangdong Li, Rixin Chen, Laurent Désaubry, Fangjian Zhou and Dan Xie

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:115

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:21

  16. Colorectal cancer (CRC) is a clinically challenging malignant tumor worldwide. As a natural product and sesquiterpene lactone, Costunolide (CTD) has been reported to possess anticancer activities. However, the...

    Authors: Hai Huang, Song Park, Haibo Zhang, Sijun Park, Wookbong Kwon, Enugyung Kim, Xiujuan Zhang, Soyoung Jang, Duhak Yoon, Seong-Kyoon Choi, Jun-koo Yi, Sung-hyun Kim, Zigang Dong, Mee-hyun Lee, Zaeyoung Ryoo and Myoung Ok Kim

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:114

    Content type: Research

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  17. Elafin is a serine protease inhibitor critical for host defence. We previously reported that Elafin was associated with the recurrence of early-stage hepatocellular carcinoma (HCC) after surgery. However, the ...

    Authors: Chenwei Wang, Yadi Liao, Wei He, Hong Zhang, Dinglan Zuo, Wenwu Liu, Zhiwen Yang, Jiliang Qiu, Yichuan Yuan, Kai Li, Yuanping Zhang, Yongjin Wang, Yunxing Shi, Yuxiong Qiu, Song Gao, Yunfei Yuan…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:113

    Content type: Research

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  18. MicroRNAs (miRNAs) regulate the expression of their target genes post-transcriptionally; thus, they are deeply involved in fundamental biological processes. miRNA clusters contain two or more miRNA-encoding ge...

    Authors: Kosuke Yoshida, Akira Yokoi, Yusuke Yamamoto and Hiroaki Kajiyama

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:112

    Content type: Review

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  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yuhui Zhang, Weibin Huang, Yujie Yuan, Jin Li, Jing Wu, Jie Yu, Yulong He, Zhewei Wei and Changhua Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:111

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:141

  20. Multiple myeloma (MM) is an incurable disease. The acquisition of resistance to drugs, including immunomodulatory drugs (IMiDs), has a negative effect on its prognosis. Cereblon (CRBN) is a key mediator of the...

    Authors: Mitsuhito Hirano, Yoichi Imai, Yuta Kaito, Takahiko Murayama, Kota Sato, Tadao Ishida, Junichi Yamamoto, Takumi Ito, Muneyoshi Futami, Masaki Ri, Hiroshi Yasui, Tamami Denda, Yukihisa Tanaka, Yasunori Ota, Masanori Nojima, Yasuhiko Kamikubo…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:110

    Content type: Research

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  21. Distant metastasis is the leading cause of death for esophageal squamous cell carcinoma (ESCC) with limited treatment options and unsatisfactory effectiveness. Bromodomain (BRD) containing proteins are emergin...

    Authors: Lian-Jing Cao, Yi-Jun Zhang, Si-Qi Dong, Xi-Zhao Li, Xia-Ting Tong, Dong Chen, Zi-Yi Wu, Xiao-Hui Zheng, Wen-Qiong Xue, Wei-Hua Jia and Jiang-Bo Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:109

    Content type: Research

    Published on:

  22. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Weiqiang Huang, Longshan Zhang, Mi Yang, Xixi Wu, Xiaoqing Wang, Wenqi Huang, Lu Yuan, Hua Pan, Yin Wang, Zici Wang, Yuting Wu, Jihong Huang, Huazhen Liang, Shaoqun Li, Liwei Liao, Laiyu Liu…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:108

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:87

  23. Cancer-secreted exosomal miRNAs regulates the biological processes of many tumours. The serum level of exosomal miR-106b-5p is significantly increased in melanoma patients. However, the role and molecular mech...

    Authors: Wenkang Luan, Yuting Ding, Haolan Xi, Hongru Ruan, Feng Lu, Shaojun Ma and Jinlong Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:107

    Content type: Research

    Published on:

  24. Although the anti-HER2 antibody trastuzumab augments patient survival in HER2+ breast cancer, a relevant number of patients progress to this treatment. In this context, novel drug combinations are needed to in...

    Authors: María del Mar Noblejas-López, Cristina Nieto-Jiménez, Eva M. Galán-Moya, David Tebar-García, Juan Carlos Montero, Atanasio Pandiella, Miguel Burgos and Alberto Ocaña

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:106

    Content type: Research

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  25. Esophageal squamous cell carcinoma (ESCC) is an aggressive and lethal cancer with a low 5 year survival rate. Identification of new therapeutic targets and its inhibitors remain essential for ESCC prevention a...

    Authors: Xuechao Jia, Chuntian Huang, Yamei Hu, Qiong Wu, Fangfang Liu, Wenna Nie, Hanyong Chen, Xiang Li, Zigang Dong and Kangdong Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:105

    Content type: Research

    Published on:

  26. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xingrong Zheng, Jiaxin Lin, Hewei Wu, Zhishuo Mo, Yunwen Lian, Peipei Wang, Zhaoxia Hu, Zhiliang Gao, Liang Peng and Chan Xie

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:104

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:475

  27. Circular RNAs (circRNAs) have emerged as a new subclass of regulatory RNAs that play critical roles in various cancers. Cancer stem cells (CSCs), a small subset of cancer cells, are believed to possess the cap...

    Authors: Yiwen Xia, Jialun Lv, Tianlu Jiang, Bowen Li, Ying Li, Zhongyuan He, Zhe Xuan, Guangli Sun, Sen Wang, Zheng Li, Weizhi Wang, Linjun Wang and Zekuan Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:103

    Content type: Research

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  28. Deciphering extracellular matrix (ECM) composition and architecture may represent a novel approach to identify diagnostic and therapeutic targets in cancer. Among the ECM components, fibronectin and its fibril...

    Authors: Sheila Spada, Annalisa Tocci, Francesca Di Modugno and Paola Nisticò

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:102

    Content type: Review

    Published on:

  29. Metastasis is the key cause of death in ovarian cancer patients. To figure out the biological nature of cancer metastasis is essential for developing effective targeted therapy. Here we investigate how long no...

    Authors: Conghui Wang, Jiaying Wang, Xiameng Shen, Mingyue Li, Yongfang Yue, Xiaodong Cheng, Weiguo Lu, Xinyu Wang and Xing Xie

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:101

    Content type: Research

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  30. Multiple myeloma (MM) cell motility is a critical step during MM dissemination throughout the body, but how it is regulated remains largely unknown. As hypercalcemia is an important clinical feature of MM, hig...

    Authors: Parinya Samart, Sudjit Luanpitpong, Yon Rojanasakul and Surapol Issaragrisil

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:100

    Content type: Research

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  31. Due to the hypoxia and nutrient deficiency microenvironment, glioblastoma (GBM) exhibits high autophagy activity and autophagy plays an important role in the progression of GBM. However, the molecular mechanis...

    Authors: Min Zhao, Yu Zhang, Yang Jiang, Kai Wang, Xiang Wang, Ding Zhou, Yan Wang, Rutong Yu and Xiuping Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:99

    Content type: Research

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  32. Bone metastasis is the leading cause of mortality and reduced quality of life in patients with metastatic prostate cancer (PCa). Long non-coding RNA activated by DNA damage (NORAD) has been observed to have an...

    Authors: Chuan-yi Hu, Juan Chen, Xin-hua Qin, Pan You, Jie Ma, Jing Zhang, He Zhang and Ji-dong Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:98

    Content type: Research

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  33. Cancer occurs in a complex tissue environment, and its progression depends largely on the tumour microenvironment (TME). The TME has a highly complex and comprehensive system accompanied by dynamic changes and...

    Authors: Haoze Li, Lihong Zhou, Jing Zhou, Qi Li and Qing Ji

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:97

    Content type: Review

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  34. Murine xenografts of pediatric leukemia accurately recapitulate genomic aberrations. How this translates to the functional capacity of cells remains unclear. Here, we studied global protein abundance, phosphor...

    Authors: Anuli C. Uzozie, Enes K. Ergin, Nina Rolf, Janice Tsui, Amanda Lorentzian, Samuel S. H. Weng, Lorenz Nierves, Theodore G. Smith, C. James Lim, Christopher A. Maxwell, Gregor S. D. Reid and Philipp F. Lange

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:96

    Content type: Research

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  35. Ectopic insulin-like growth factor binding protein 3 (IGFBP3) expression has been shown to enhance cell migration and lymph node metastasis of oral squamous cell carcinoma (OSCC) cells. However, OSCC patients ...

    Authors: Ssu-Han Wang, Yu-Lin Chen, Jenn-Ren Hsiao, Fang-Yu Tsai, Shih Sheng Jiang, Alan Yueh-Luen Lee, Hui-Jen Tsai and Ya-Wen Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:95

    Content type: Research

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  36. In the last decades, the concept of metabolic rewiring as a cancer hallmark has been expanded beyond the “Warburg effect” and the importance of other metabolic routes, including lipid metabolism, has emerged. ...

    Authors: Serena Castelli, Fabio Ciccarone, Daniela Tavian and Maria Rosa Ciriolo

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:94

    Content type: Research

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  37. There is no consensus about the effective dosages of melatonin in cancer management, thus, it is imperative to fully understand the dose-dependent responsiveness of cancer cells to melatonin and the underlying...

    Authors: Liwei Lang, Yuanping Xiong, Nestor Prieto-Dominguez, Reid Loveless, Caleb Jensen, Chloe Shay and Yong Teng

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:93

    Content type: Research

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  38. Emerging evidence confirms that lncRNAs (long non-coding RNAs) are potential biomarkers that play vital roles in tumors. ZNF582-AS1 is a novel lncRNA that serves as a potential prognostic marker of cancers. Ho...

    Authors: Wuping Yang, Kenan Zhang, Lei Li, Yawei Xu, Kaifang Ma, Haibiao Xie, Jingcheng Zhou, Lin Cai, Yanqing Gong and Kan Gong

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:92

    Content type: Research

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  39. Pancreatic ductal adenocarcinoma (PDAC) is a very lethal disease, with minimal therapeutic options. Aberrant tyrosine kinase activity influences tumor growth and is regulated by phosphorylation. We investigate...

    Authors: T. Y. S. Le Large, M. F. Bijlsma, B. El Hassouni, G. Mantini, T. Lagerweij, A. A. Henneman, N. Funel, B. Kok, T. V. Pham, R. de Haas, L. Morelli, J. C. Knol, S. R. Piersma, G. Kazemier, H. W. M. van Laarhoven, E. Giovannetti…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:91

    Content type: Research

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  40. FBXW7 m6A modification plays an important role in lung adenocarcinoma (LUAD) progression; however, the underlying mechanisms remain unclear.

    Authors: Yingtong Wu, Ning Chang, Yong Zhang, Xinxin Zhang, Leidi Xu, Yinggang Che, Tianyun Qiao, Bin Wu, Ying Zhou, Jun Jiang, Jie Xiong, Jian Zhang and Jian Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:90

    Content type: Research

    Published on:

  41. Recent developments in abscopal effect strongly support the use of radiotherapy for the treatment of metastatic disease. However, deeper understanding of the molecular mechanisms underlying the abscopal effect...

    Authors: Anna Tesei, Chiara Arienti, Gianluca Bossi, Spartaco Santi, Ilaria De Santis, Alessandro Bevilacqua, Michele Zanoni, Sara Pignatta, Michela Cortesi, Alice Zamagni, Gianluca Storci, Massimiliano Bonafè, Anna Sarnelli, Antonino Romeo, Carola Cavallo, Armando Bartolazzi…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:89

    Content type: Research

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  42. WD repeat domain 3 (WDR3) is involved in a variety of cellular processes including gene regulation, cell cycle progression, signal transduction and apoptosis. However, the biological role of WDR3 in pancreatic...

    Authors: Wenjie Su, Shikai Zhu, Kai Chen, Hongji Yang, Mingwu Tian, Qiang Fu, Ganggang Shi, Shijian Feng, Dianyun Ren, Xin Jin and Chong Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:88

    Content type: Research

    Published on:

  43. Irradiation has emerged as a valid tool for nasopharyngeal carcinoma (NPC) in situ treatment; however, NPC derived from tissues treated with irradiation is a main cause cancer-related death. The purpose of thi...

    Authors: Weiqiang Huang, Longshan Zhang, Mi Yang, Xixi Wu, Xiaoqing Wang, Wenqi Huang, Lu Yuan, Hua Pan, Yin Wang, Zici Wang, Yuting Wu, Jihong Huang, Huazhen Liang, Shaoqun Li, Liwei Liao, Laiyu Liu…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:87

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:108

  44. Cholangiocarcinoma is a highly malignant cancer with very dismal prognosis. Perihilar cholangiocarcinoma(pCCA) accounts for more than 50% of all cholangiocarcinoma and is well-characterized for its low rate of...

    Authors: Zhipeng Li, Jialiang Liu, Tianli Chen, Rongqi Sun, Zengli Liu, Bo Qiu, Yunfei Xu and Zongli Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:86

    Content type: Research

    Published on:

  45. Alternative polyadenylation (APA) is an important mechanism of gene expression regulation through generation of RNA isoforms with distinct 3′ termini. Increasing evidence has revealed that APA is actively invo...

    Authors: Sheng Tan, Ming Zhang, Xinglong Shi, Keshuo Ding, Qiang Zhao, Qianying Guo, Hao Wang, Zhengsheng Wu, Yani Kang, Tao Zhu, Jielin Sun and Xiaodong Zhao

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:85

    Content type: Research

    Published on:

  46. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ping Zhou, Jiaqi Qin, Yuan Li, Guoxia Li, Yinsong Wang, Ning Zhang, Peng Chen and Chunyu Li

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:84

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:115

  47. Dedifferentiated liposarcoma (DDLPS), a tumor that lacks effective treatment strategies and is associated with poor outcomes, expresses amplified MDM2 in the presence of wild-type p53. MDM2 ubiquitination of p...

    Authors: Valentina Zuco, Sandro Pasquali, Monica Tortoreto, Silvia Brich, Stefano Percio, Gian Paolo Dagrada, Chiara Colombo, Roberta Sanfilippo, Calogero Lauricella, Mrinal Gounder, Rihan El Bezawy, Marta Barisella, Angelo Paolo Dei Tos, Paolo Giovanni Casali, Alessandro Gronchi, Silvia Stacchiotti…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:83

    Content type: Research

    Published on:

  48. Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited therapeutic opportunities. Recently, splicing factors have gained attention as potential targets for cancer treatment...

    Authors: Esmee Koedoot, Eline van Steijn, Marjolein Vermeer, Román González-Prieto, Alfred C. O. Vertegaal, John W. M. Martens, Sylvia E. Le Dévédec and Bob van de Water

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:82

    Content type: Research

    Published on:

  49. Single-cell RNA sequencing (scRNA-seq), a technology that analyzes transcriptomes of complex tissues at single-cell levels, can identify differential gene expression and epigenetic factors caused by mutations ...

    Authors: Yijie Zhang, Dan Wang, Miao Peng, Le Tang, Jiawei Ouyang, Fang Xiong, Can Guo, Yanyan Tang, Yujuan Zhou, Qianjin Liao, Xu Wu, Hui Wang, Jianjun Yu, Yong Li, Xiaoling Li, Guiyuan Li…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:81

    Content type: Review

    Published on:

  50. TMEM52B is a novel gene broadly expressed in a variety of normal human tissues. However, the biological function of TMEM52B expression in cancer is largely unknown.

    Authors: Yunhee Lee, Dongjoon Ko, Junghwa Yoon, Younghoon Lee and Semi Kim

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:58

    Content type: Research

    Published on:

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