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  1. Research

    The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis

    The tumor acidic microenvironment, a common biochemical event in solid tumors, offers evolutional advantage for tumors cells and even enhances their aggressive phenotype. However, little is known about the mol...

    Zhi-hang Zhou, Jin-wen Song, Wen Li, Xue Liu, Liu Cao, Lu-ming Wan, Ying-xia Tan, Shou-ping Ji, Yu-mei Liang and Feng Gong

    Journal of Experimental & Clinical Cancer Research 2017 36:130

    Published on: 19 September 2017

  2. Research

    PDL1 And LDHA act as ceRNAs in triple negative breast cancer by regulating miR-34a

    The purpose of this study was to elucidate the regulation of programmed death ligand 1 (PDL1), lactate dehydrogenase A (LDHA) and miR-34a in triple negative breast cancer (TNBC) and to explore the function and...

    Xiaojia Huang, Xinhua Xie, Hua Wang, Xiangsheng Xiao, Lu Yang, Zhi Tian, Xiaofang Guo, Lijuan Zhang, Hailin Tang and Xiaoming Xie

    Journal of Experimental & Clinical Cancer Research 2017 36:129

    Published on: 15 September 2017

  3. Review

    Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research

    The increasing use of genomics to define the pattern of actionable mutations and to test and validate new therapies for individual cancer patients, and the growing application of liquid biopsy to dynamically t...

    Nicola Silvestris, Gennaro Ciliberto, Paolo De Paoli, Giovanni Apolone, Maria Luisa Lavitrano, Marco A. Pierotti and Giorgio Stanta

    Journal of Experimental & Clinical Cancer Research 2017 36:128

    Published on: 13 September 2017

  4. Research

    Nucleolar and spindle associated protein 1 promotes the aggressiveness of astrocytoma by activating the Hedgehog signaling pathway

    The prognosis of human astrocytoma is poor, and the molecular alterations underlying its pathogenesis still needed to be elucidated. Nucleolar and spindle associated protein 1 (NUSAP1) was observed in several ...

    Xianqiu Wu, Benke Xu, Chao Yang, Wentao Wang, Dequan Zhong, Zhan Zhao, Longshuang He, Yuanjun Hu, Lili Jiang, Jun Li, Libing Song and Wei Zhang

    Journal of Experimental & Clinical Cancer Research 2017 36:127

    Published on: 12 September 2017

  5. Research

    p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions

    As an important cellular stress sensor phosphoprotein p53 can trigger cell cycle arrest and apoptosis and regulate autophagy. The p53 activity mainly depends on its transactivating function, however, how p53 c...

    Alessia Garufi, Giuseppa Pistritto, Silvia Baldari, Gabriele Toietta, Mara Cirone and Gabriella D’Orazi

    Journal of Experimental & Clinical Cancer Research 2017 36:126

    Published on: 11 September 2017

  6. Research

    Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells

    Pancreatic cancer is generally acknowledged as the most common primary malignant tumor, and it is known to be resistant to conventional chemotherapy. Novel, selective antitumor agents are pressingly needed.

    Zihang Xu, Fei Zhang, Chao Bai, Chao Yao, Hairong Zhong, Chunpu Zou and Xiao Chen

    Journal of Experimental & Clinical Cancer Research 2017 36:124

    Published on: 11 September 2017

  7. Research

    ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population

    ICG-001, a small molecule, binds CREB-binding protein (CBP) to disrupt its interaction with β-catenin and inhibits CBP function as a co-activator of Wnt/β-catenin-mediated transcription. Given its ability to i...

    Yi Liu, Hui Chen, Peiming Zheng, Yingxia Zheng, Qin Luo, Guohua Xie, Yanhui Ma and Lisong Shen

    Journal of Experimental & Clinical Cancer Research 2017 36:125

    Published on: 11 September 2017

  8. Research

    Annexin A2 contributes to cisplatin resistance by activation of JNK-p53 pathway in non-small cell lung cancer cells

    Development of resistance to therapy continues to be a serious clinical problem in lung cancer management. We previously identified that Annexin A2 is significantly up-regulated in cisplatin-resistant non-smal...

    Xiaomin Feng, Hao Liu, Zhijie Zhang, Yixue Gu, Huisi Qiu and Zhimin He

    Journal of Experimental & Clinical Cancer Research 2017 36:123

    Published on: 8 September 2017

  9. Research

    Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer

    Studying the intracellular distribution of pharmacological agents, including anticancer compounds, is of central importance in biomedical research. It constitutes a prerequisite for a better understanding of t...

    Bernhard Englinger, Sebastian Kallus, Julia Senkiv, Daniela Heilos, Lisa Gabler, Sushilla van Schoonhoven, Alessio Terenzi, Patrick Moser, Christine Pirker, Gerald Timelthaler, Walter Jäger, Christian R. Kowol, Petra Heffeter, Michael Grusch and Walter Berger

    Journal of Experimental & Clinical Cancer Research 2017 36:122

    Published on: 7 September 2017

  10. Research

    High performance of targeted next generation sequencing on variance detection in clinical tumor specimens in comparison with current conventional methods

    Next generation sequencing (NGS) is being increasingly applied for assisting cancer molecular diagnosis. However, it is still needed to validate NGS accuracy on detection of DNA alternations based on a large n...

    Dan Su, Dadong Zhang, Kaiyan Chen, Jing Lu, Junzhou Wu, Xinkai Cao, Lisha Ying, Qihuang Jin, Yizhou Ye, Zhenghua Xie, Lei Xiong, Weimin Mao and Fugen Li

    Journal of Experimental & Clinical Cancer Research 2017 36:121

    Published on: 7 September 2017

  11. Research

    (S)-crizotinib induces apoptosis in human non-small cell lung cancer cells by activating ROS independent of MTH1

    Non–small cell lung cancer (NSCLC) accounts for approximately 80–85% of all lung cancers and is usually diagnosed at an advanced stage with poor prognosis. Targeted therapy has produced unprecedented outcomes ...

    Xuanxuan Dai, Guilong Guo, Peng Zou, Ri Cui, Weiqian Chen, Xi Chen, Changtian Yin, Wei He, Rajamanickam Vinothkumar, Fan Yang, Xiaohua Zhang and Guang Liang

    Journal of Experimental & Clinical Cancer Research 2017 36:120

    Published on: 7 September 2017

  12. Research

    Ternary cocktail nanoparticles for sequential chemo-photodynamic therapy

    Previous clinical trials have already demonstrated that combinations of two or more drugs were more effective in the cancer treatment, especially sequential photodynamic design combing with sequential chemothe...

    Li Fan, Saisai Zhao, Qian Yang, Jiali Tan, Chaojun Song and Hong Wu

    Journal of Experimental & Clinical Cancer Research 2017 36:119

    Published on: 6 September 2017

  13. Research

    Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination

    Resistance to adjuvant radiotherapy is a major cause of treatment failure in patients with glioblastoma (GBM). Autophagy inhibitors have been shown to enhance the efficacy of radiotherapy for certain solid tum...

    Xin Zhang, Ran Xu, Chao Zhang, Yangyang Xu, Mingzhi Han, Bin Huang, Anjing Chen, Chen Qiu, Frits Thorsen, Lars Prestegarden, Rolf Bjerkvig, Jian Wang and Xingang Li

    Journal of Experimental & Clinical Cancer Research 2017 36:118

    Published on: 5 September 2017

  14. Research

    Maintenance of stemness is associated with the interation of LRP6 and heparin-binding protein CCN2 autocrined by hepatocellular carcinoma

    The overall response rate of hepatocellular carcinoma (HCC) to chemotherapy is poor. In our previous study, oxaliplatin-resistant HCC is found to exhibit an enhanced stemness, and increased levels of CCN2 and ...

    Qingan Jia, Yang Bu, Zhiming Wang, Bendong Chen, Qiangbo Zhang, Songning Yu and Qingguang Liu

    Journal of Experimental & Clinical Cancer Research 2017 36:117

    Published on: 4 September 2017

  15. Research

    Combination therapy of PKCζ and COX-2 inhibitors synergistically suppress melanoma metastasis

    Metastatic malignant melanoma is one of the most aggressive malignancies and its treatment remains challenging. Recent studies demonstrate that the melanoma metastasis has correlations with the heightened acti...

    Ping Zhou, Jiaqi Qin, Yuan Li, Guoxia Li, Yinsong Wang, Ning Zhang, Peng Chen and Chunyu Li

    Journal of Experimental & Clinical Cancer Research 2017 36:115

    Published on: 2 September 2017

  16. Research

    NLRP3 inflammasome activation promotes inflammation-induced carcinogenesis in head and neck squamous cell carcinoma

    NLRP3 inflammasome acts as a danger signal sensor that triggers and coordinates the inflammatory response. However, the roles of NLRP3 inflammasome in the tumorigenesis and development of cancer stem cells (CS...

    Cong-Fa Huang, Lei Chen, Yi-Cun Li, Lei Wu, Guang-Tao Yu, Wen-Feng Zhang and Zhi-Jun Sun

    Journal of Experimental & Clinical Cancer Research 2017 36:116

    Published on: 2 September 2017

  17. Research

    Epigenetic silencing of miR-493 increases the resistance to cisplatin in lung cancer by targeting tongue cancer resistance-related protein 1(TCRP1)

    The potential mechanisms regarding how methylation of microRNA(miRNA) CpG Island could regulate cancer cell chemo-resistance remains unclear. This study aims to explore the epigenetic dysregulation mechanism o...

    Yixue Gu, Zhijie Zhang, Jiang Yin, Jiahui Ye, Yin Song, Hao Liu, Yan Xiong, Minying Lu, Guopei Zheng and Zhimin He

    Journal of Experimental & Clinical Cancer Research 2017 36:114

    Published on: 31 August 2017

  18. Research

    Exosomes isolated from cancer patients’ sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells

    Horizontal transfer of malignant traits from the primary tumor to distant organs, through blood circulating factors, has recently become a thoroughly studied metastatic pathway to explain cancer dissemination....

    Mohamed Abdouh, Dana Hamam, Zu-Hua Gao, Vincenzo Arena, Manuel Arena and Goffredo Orazio Arena

    Journal of Experimental & Clinical Cancer Research 2017 36:113

    Published on: 30 August 2017

  19. Research

    Annexin A2 could enhance multidrug resistance by regulating NF-κB signaling pathway in pediatric neuroblastoma

    Chemotherapy is one of major therapeutic regimens for neuroblastoma (NB) in children. However, recurrence and metastasis associated with poor prognosis caused by acquired multidrug resistance remains a challen...

    Yi Wang, Kai Chen, Yihong Cai, Yuanxia Cai, Xiaojun Yuan, Lifeng Wang, Zhixiang Wu and Yeming Wu

    Journal of Experimental & Clinical Cancer Research 2017 36:111

    Published on: 16 August 2017

  20. Research

    Silencing the Girdin gene enhances radio-sensitivity of hepatocellular carcinoma via suppression of glycolytic metabolism

    Radiotherapy has been used increasingly to treat primary hepatocellular carcinoma. Clinically, the main cause of radiotherapy failure is cellular radioresistance, conferred via glycolytic metabolism. Our previ...

    Li Yu, Yifan Sun, Jingjing Li, Yan Wang, Yuxing Zhu, Yong Shi, Xiaojun Fan, Jianda Zhou, Ying Bao, Jie Xiao, Ke Cao and Peiguo Cao

    Journal of Experimental & Clinical Cancer Research 2017 36:110

    Published on: 15 August 2017

  21. Research

    The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells

    Glioblastoma (GBM) is a highly migratory, invasive, and angiogenic brain tumor. Like vascular endothelial growth factor-A (VEGF-A), placental growth factor (PlGF) promotes GBM angiogenesis. VEGF-A is a ligand ...

    Maria Grazia Atzori, Lucio Tentori, Federica Ruffini, Claudia Ceci, Lucia Lisi, Elena Bonanno, Manuel Scimeca, Eskil Eskilsson, Thomas Daubon, Hrvoje Miletic, Lucia Ricci Vitiani, Roberto Pallini, Pierluigi Navarra, Rolf Bjerkvig, Stefania D’Atri, Pedro Miguel Lacal…

    Journal of Experimental & Clinical Cancer Research 2017 36:106

    Published on: 10 August 2017

  22. Research

    Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2)

    Pancreatic cancer is susceptible to gemcitabine resistance, and patients receive less benefit from gemcitabine chemotherapy. Previous studies report that gambogic acid possesses antineoplastic properties; howe...

    Guanggai Xia, Hongcheng Wang, Ziliang Song, Qingcai Meng, Xiuyan Huang and Xinyu Huang

    Journal of Experimental & Clinical Cancer Research 2017 36:107

    Published on: 10 August 2017

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