Articles

Embedding similarities between embryos and circulating tumor cells: fundamentals of abortifacients used for cancer metastasis chemoprevention

The global epidemiological studies reported lower cancer risk after long-term use of contraceptives. Our systematic studies demonstrated that abortifacients are effective in preventing cancer metastases induce...

Authors: Jie Wang, Xiaobo Yu, Huayi Peng, Yusheng Lu, Shuhui Li, Qing Shi, Jian Liu, Haiyan Dong, Vladimir Katanaev and Lee Jia

LNCAROD enhances hepatocellular carcinoma malignancy by activating glycolysis through induction of pyruvate kinase isoform PKM2

Mounting evidence has suggested the essential role of long non-coding RNAs (lncRNAs) in a plethora of malignant tumors, including hepatocellular carcinoma. However, the underlyling mechanisms of lncRNAs remain...

Authors: Guizhi Jia, Yan Wang, Chengjie Lin, Shihui Lai, Hongliang Dai, Zhiqian Wang, Luo Dai, Huizhao Su, Yanjie Song, Naiwen Zhang, Yukuan Feng and Bo Tang

Correction to: Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ

Authors: Jing Cai, Mei Yi, Yixin Tan, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong and Bo Xiang

Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer

Chemoresistance is the major cause of chemotherapy failure in patients with colorectal cancer (CRC). Protein tyrosine kinase 6 (PTK6) is aberrantly overexpressed in clinical CRC tissues undergoing chemotherapy...

Authors: Chaoqun Liu, Zhihua Pan, Qian Chen, Zetao Chen, Weiwei Liu, Ling Wu, Muhong Jiang, Wandie Lin, Yujie Zhang, Weihao Lin, Rui Zhou and Liang Zhao

Correction to: Pyroptosis: a new paradigm of cell death for fighting against cancer

Authors: Yixin Tan, Quanzhu Chen, Xiaoling Li, Zhaoyang Zeng, Wei Xiong, Guiyuan Li, Xiayu Li, Jianbo Yang, Bo Xiang and Mei Yi

Activin-A impedes the establishment of CD4⁺ T cell exhaustion and enhances anti-tumor immunity in the lung

Although tumor-infiltrating T cells represent a favorable prognostic marker for cancer patients, the majority of these cells are rendered with an exhausted phenotype. Hence, there is an unmet need to identify ...

Authors: Ioannis Morianos, Aikaterini Tsitsopoulou, Konstantinos Potaris, Dimitrios Valakos, Ourania Fari, Giannis Vatsellas, Clementine Bostantzoglou, Andreas Photiades, Mina Gaga, Georgina Xanthou and Maria Semitekolou

RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma

Long non-coding RNA (LncRNA) controls cell proliferation and plays a significant role in the initiation and progression of esophageal squamous cell carcinoma (ESCC). N6-methyladenosine (m6A) modification now i...

Authors: Yuanbo Cui, Chunyan Zhang, Shanshan Ma, Zhe Li, Wenjie Wang, Ya Li, Yingchao Ma, Jiarui Fang, Yaping Wang, Wei Cao and Fangxia Guan

A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene

Polysialic acid (polySia) modifies six cell surface proteins in humans mainly during fetal development and some blood cells in adults. Two genes in humans, ST8SIA2 and ST8SIA4, code for polysialyltransferases tha...

Authors: Gregory R. Moe, Lindsay M. Steirer, Joshua A. Lee, Adarsha Shivakumar and Alejandro D. Bolanos

TAGLN mediated stiffness-regulated ovarian cancer progression via RhoA/ROCK pathway

Ovarian cancer (OC) progression is an unmet medical challenge. Since omental metastases were palpated harder than their primary counterparts during cytoreductive surgery of patients with epithelial ovarian can...

Authors: Xiao Wei, Hua Lou, Dongchen Zhou, Yijuan Jia, Huayi Li, Quanfu Huang, Jingjing Ma, Zongyuan Yang, Chaoyang Sun, Yunchong Meng, Sen Xu, Xin Yang, Xiaoting Li, Teng Ji, Zhongzhen Guo and Qinglei Gao

ZNF507 affects TGF-β signaling via TGFBR1 and MAP3K8 activation in the progression of prostate cancer to an aggressive state

The progression of prostate cancer (PC) to the highly aggressive metastatic castration-resistant prostate cancer (mCRPC) or neuroendocrine prostate cancer (NEPC) is a fatal condition and the underlying molecul...

Authors: Wookbong Kwon, Seong-Kyoon Choi, Daehwan Kim, Hyeon-Gyeom Kim, Jin-Kyu Park, Jee Eun Han, Gil-Jae Cho, Sungho Yun, Wookyung Yu, Se-Hyeon Han, Yun-Sok Ha, Jun Nyung Lee, Tae Gyun Kwon, Dong-Hyung Cho, Jun-Koo Yi, Myoung Ok Kim…

circHMGCS1–016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma

Accumulating evidence indicates that circRNAs may serve as essential regulators in the progression of several human cancers, but the function and mechanism of circRNAs in intrahepatic cholangiocarcinoma (ICC) ...

Authors: Ya-Ping Xu, Ze-Ning Dong, Si-Wei Wang, Yi-Min Zheng, Chi Zhang, Ying-Qun Zhou, Yu-Jie Zhao, Yan Zhao, Feng Wang, Rui Peng, Mao-Chun Tang, Dou-sheng Bai, Xiao-Yong Huang and Chuan-Yong Guo

The non-canonical mechanism of ER stress-mediated progression of prostate cancer

The development of persistent endoplasmic reticulum (ER) stress is one of the cornerstones of prostate carcinogenesis; however, the mechanism is missing. Also, alcohol is a physiological ER stress inducer, and...

Authors: Artem N. Pachikov, Ryan R. Gough, Caroline E. Christy, Mary E. Morris, Carol A. Casey, Chad A. LaGrange, Ganapati Bhat, Anatoly V. Kubyshkin, Iryna I. Fomochkina, Evgeniya Y. Zyablitskaya, Tatiana P. Makalish, Elena P. Golubinskaya, Kateryna A. Davydenko, Sergey N. Eremenko, Jean-Jack M. Riethoven, Amith S. Maroli…

Regorafenib enhances anti-PD1 immunotherapy efficacy in murine colorectal cancers and their combination prevents tumor regrowth

Patients with advanced colorectal cancer (CRC) have a poor prognosis. Combinations of immunotherapies and anti-angiogenic agents are currently being evaluated in clinical trials. In this study, the multikinase...

Authors: Dennis Doleschel, Sabine Hoff, Susanne Koletnik, Anne Rix, Dieter Zopf, Fabian Kiessling and Wiltrud Lederle

Long non-coding RNA SLC2A1-AS1 induced by GLI3 promotes aerobic glycolysis and progression in esophageal squamous cell carcinoma by sponging miR-378a-3p to enhance Glut1 expression

Emerging evidence demonstrates that lncRNAs play pivotal roles in tumor energy metabolism; however, the detailed mechanisms of lncRNAs in the regulation of tumor glycolysis remain largely unknown.

Authors: Hongtao Liu, Qing Zhang, Yinsen Song, Yibin Hao, Yunxia Cui, Xin Zhang, Xueying Zhang, Yue Qin, Guangzhao Zhu, Feng Wang, Jinghan Dang, Shanshan Ma, Yanting Zhang, Wenna Guo, Shenglei Li, Fangxia Guan…

PEGylated recombinant human hyaluronidase (PEGPH20) pre-treatment improves intra-tumour distribution and efficacy of paclitaxel in preclinical models

Scarce drug penetration in solid tumours is one of the possible causes of the limited efficacy of chemotherapy and is related to the altered tumour microenvironment. The abnormal tumour extracellular matrix (E...

Authors: Lavinia Morosi, Marina Meroni, Paolo Ubezio, Ilaria Fuso Nerini, Lucia Minoli, Luca Porcu, Nicolò Panini, Marika Colombo, Barbara Blouw, David W. Kang, Enrico Davoli, Massimo Zucchetti, Maurizio D’Incalci and Roberta Frapolli

The CD112R/CD112 axis: a breakthrough in cancer immunotherapy

The recent discovery of immune checkpoint inhibitors is a significant milestone in cancer immunotherapy research. However, some patients with primary or adaptive drug resistance might not benefit from the over...

Authors: Taofei Zeng, Yuqing Cao, Tianqiang Jin, Yu Tian, Chaoliu Dai and Feng Xu

ALKBH5-HOXA10 loop-mediated JAK2 m6A demethylation and cisplatin resistance in epithelial ovarian cancer

Chemotherapy resistance remains a barrier to improving the prognosis of epithelial ovarian cancer (EOC). ALKBH5 has recently been shown to be one of the RNA N6-methyladenosine (m6A) demethyltransferases associ...

Authors: Sipei Nie, Lin Zhang, Jinhui Liu, Yicong Wan, Yi Jiang, Jing Yang, Rui Sun, Xiaolling Ma, Guodong Sun, Huangyang Meng, Mengting Xu and Wenjun Cheng

Neuromedin U induces an invasive phenotype in CRC cells expressing the NMUR2 receptor

Successful colorectal cancer (CRC) therapy often depends on the accurate identification of primary tumours with invasive potential. There is still a lack of identified pathological factors associated with dise...

Authors: Patrycja Przygodzka, Ewelina Sochacka, Kamila Soboska, Marcin Pacholczyk, Izabela Papiewska-Pająk, Tomasz Przygodzki, Przemysław Płociński, Steven Ballet, An De Prins and Joanna Boncela

Downregulated CLIP3 induces radioresistance by enhancing stemness and glycolytic flux in glioblastoma

Glioblastoma Multiforme (GBM) is a malignant primary brain tumor in which the standard treatment, ionizing radiation (IR), achieves a median survival of about 15 months. GBM harbors glioblastoma stem-like cell...

Authors: Hyunkoo Kang, Sungmin Lee, Kyeongmin Kim, Jaewan Jeon, Seok-Gu Kang, HyeSook Youn, Hae Yu Kim and BuHyun Youn

The role of dosimetry and biological effects in metastatic castration–resistant prostate cancer (mCRPC) patients treated with ²²³Ra: first in human study

²²³Ra is currently used for treatment of metastatic castration resistant prostate cancer patients (mCRPC) bone metastases with fixed standard activity. Individualized treatments, based on adsorbed dose (AD) in ta...

Authors: Rosa Sciuto, Sandra Rea, Sara Ungania, Antonella Testa, Valentina Dini, Maria Antonella Tabocchini, Clarice Patrono, Antonella Soriani, Valentina Palma, Raffaella Marconi and Lidia Strigari

Sulfarotene, a synthetic retinoid, overcomes stemness and sorafenib resistance of hepatocellular carcinoma via suppressing SOS2-RAS pathway

Recurrent hepatocellular carcinoma (HCC) shows strong resistance to sorafenib, and the tumor-repopulating cells (TRCs) with cancer stem cell-like properties are considered a driver for its high recurrent rate ...

Authors: Feng Qi, Wenxing Qin, Yao Zhang, Yongde Luo, Bing Niu, Quanlin An, Biwei Yang, Keqing Shi, Zhijie Yu, Junwei Chen, Xin Cao and Jinglin Xia

Combinational blockade of MET and PD-L1 improves pancreatic cancer immunotherapeutic efficacy

Dysregulated expression and activation of receptor tyrosine kinases (RTKs) are associated with a range of human cancers. However, current RTK-targeting strategies exert little effect on pancreatic cancer, a hi...

Authors: Enliang Li, Xing Huang, Gang Zhang and Tingbo Liang

The HIF1α-PDGFD-PDGFRα axis controls glioblastoma growth at normoxia/mild-hypoxia and confers sensitivity to targeted therapy by echinomycin

Glioblastoma multiforme (GBM), a lethal brain tumor, remains the most daunting challenge in cancer therapy. Overexpression and constitutive activation of PDGFs and PDGFRα are observed in most GBM; however, ava...

Authors: Gong Peng, Yin Wang, Pengfei Ge, Christopher Bailey, Peng Zhang, Di Zhang, Zhaoli Meng, Chong Qi, Qian Chen, Jingtao Chen, Junqi Niu, Pan Zheng, Yang Liu and Yan Liu

Retraction Note: TLE3 represses colorectal cancer proliferation by inhibiting MAPK and AKT signaling pathways

Authors: Run-Wei Yang, Ying-Yue Zeng, Wen-Ting Wei, Yan-Mei Cui, Hui-Ying Sun, Yue-Long Cai, Xin-Xin Nian, Yun-Teng Hu, Yu-Ping Quan, Sheng-Lu Jiang, Meng Wang, Ya-Li Zhao, Jun-Feng Qiu, Ming-Xuan Li, Jia-Huan Zhang, Mei-Rong He…

Chemoresistance is mediated by ovarian cancer leader cells in vitro

Leader cells are a subset of cancer cells that coordinate the complex cell-cell and cell-matrix interactions required for ovarian cancer migration, invasion, tumour deposition and are negatively associated wit...

Authors: Nazanin Karimnia, Amy L. Wilson, Emma Green, Amelia Matthews, Thomas W. Jobling, Magdalena Plebanski, Maree Bilandzic and Andrew N. Stephens

CIRP promotes the progression of non-small cell lung cancer through activation of Wnt/β-catenin signaling via CTNNB1

Cold-inducible RNA binding protein (CIRP) is a newly discovered proto-oncogene. In this study, we investigated the role of CIRP in the progression of non-small cell lung cancer (NSCLC) using patient tissue sam...

Authors: Yi Liao, Jianguo Feng, Weichao Sun, Chao Wu, Jingyao Li, Tao Jing, Yuteng Liang, Yonghui Qian, Wenlan Liu and Haidong Wang

SHOX2 cooperates with STAT3 to promote breast cancer metastasis through the transcriptional activation of WASF3

Metastasis is most often the root cause of cancer-related death. Human short stature homeobox 2 (SHOX2), a homeodomain transcription factor, is a novel inducer of epithelial-to-mesenchymal transition in breast...

Authors: Yong Teng, Reid Loveless, Elayne M Benson, Li Sun, Austin Y Shull and Chloe Shay

Cyclin G2 reverses immunosuppressive tumor microenvironment and potentiates PD-1 blockade in glioma

Expression of aberrant cyclin G2 is a key factor contributing to cancer biological processes, including glioma. However, the potential underlying mechanisms of cyclin G2 in the glioma tumor immune microenviron...

Authors: Sen Li, Chenyang Zhao, Jinlan Gao, Xinbin Zhuang, Shuang Liu, Xuesha Xing, Qi Liu, Chen Chen, Shusen Wang and Yang Luo

Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK

Recent studies have investigated the role of circular RNAs (circRNAs) as significant regulatory factors in multiple cancer progression. Nevertheless, the biological functions of circRNAs and the underlying mec...

Authors: Chaofan Peng, Yuqian Tan, Peng Yang, Kangpeng Jin, Chuan Zhang, Wen Peng, Lu Wang, Jiahui Zhou, Ranran Chen, Tuo Wang, Chi Jin, Jiangzhou Ji, Yifei Feng, Junwei Tang and Yueming Sun

The Anterior GRadient (AGR) family proteins in epithelial ovarian cancer

Epithelial ovarian cancer (EOC) is the most common gynecologic disorder. Even with the recent progresses made towards the use of new therapeutics, it still represents the most lethal gynecologic malignancy in ...

Authors: Delphine Fessart, Jacques Robert, Cecile Hartog, Eric Chevet, Frederic Delom and Guillaume Babin

MEN1 silencing aggravates tumorigenic potential of AR-independent prostate cancer cells through nuclear translocation and activation of JunD and β-catenin

Recent studies highlighted the increased frequency of AR-low or -negative prostate cancers (PCas) and the importance of AR-independent mechanisms in driving metastatic castration-resistant PCa (mCRPC) developm...

Authors: Yakun Luo, Virginie Vlaeminck-Guillem, Silvère Baron, Sarah Dallel, Chang Xian Zhang and Muriel Le Romancer

CRISPR/Cas9 revitalizes adoptive T-cell therapy for cancer immunotherapy

Cancer immunotherapy has gained attention as the supreme therapeutic modality for the treatment of various malignancies. Adoptive T-cell therapy (ACT) is one of the most distinctive modalities of this therapeu...

Authors: Sasan Ghaffari, Nastaran Khalili and Nima Rezaei

The component of the m⁶A writer complex VIRMA is implicated in aggressive tumor phenotype, DNA damage response and cisplatin resistance in germ cell tumors

Germ cell tumors (GCTs) are developmental cancers, tightly linked to embryogenesis and germ cell development. The recent and expanding field of RNA modifications is being increasingly implicated in such molecu...

Authors: Vera Miranda-Gonçalves, João Lobo, Catarina Guimarães-Teixeira, Daniela Barros-Silva, Rita Guimarães, Mariana Cantante, Isaac Braga, Joaquina Maurício, Christoph Oing, Friedemann Honecker, Daniel Nettersheim, Leendert H. J. Looijenga, Rui Henrique and Carmen Jerónimo

Poliovirus receptor (PVR)-like protein cosignaling network: new opportunities for cancer immunotherapy

Immune checkpoint molecules, also known as cosignaling molecules, are pivotal cell-surface molecules that control immune cell responses by either promoting (costimulatory molecules) or inhibiting (coinhibitory...

Authors: Baokang Wu, Chongli Zhong, Qi Lang, Zhiyun Liang, Yizhou Zhang, Xin Zhao, Yang Yu, Heming Zhang, Feng Xu and Yu Tian

Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer

Recently, a variety of clinical trials have shown that apatinib, a small-molecule anti-angiogenic drug, exerts promising inhibitory effects on multiple solid tumors, including non-small cell lung cancer (NSCLC...

Authors: Chunfeng Xie, Xu Zhou, Chunhua Liang, Xiaoting Li, Miaomiao Ge, Yue Chen, Juan Yin, Jianyun Zhu and Caiyun Zhong

SCD1, autophagy and cancer: implications for therapy

Autophagy is an intracellular degradation system that removes unnecessary or dysfunctional components and recycles them for other cellular functions. Over the years, a mutual regulation between lipid metabolis...

Authors: Francesca Ascenzi, Claudia De Vitis, Marcello Maugeri-Saccà, Christian Napoli, Gennaro Ciliberto and Rita Mancini

Pyroptosis at the forefront of anticancer immunity

Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two major contributors to poor therapeutic responses during cancer intervention. Pyroptosis, a lytic and inflammatory programm...

Authors: Reid Loveless, Ryan Bloomquist and Yong Teng

Synthetic lethality and synergetic effect: the effective strategies for therapy of IDH-mutated cancers

Mutant isocitrate dehydrogenase 1/2 (mIDH1/2) gain a novel function for the conversion of α-ketoglutarate (α-KG) to oncometabolite R-2-hydroxyglutarate (R-2-HG). Two molecular entities namely enasidenib (AG-221) ...

Authors: Kun Yao, Hua Liu, Jiajun Yin, Jianmin Yuan and Hong Tao

Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish

Liver cancer, mainly hepatocellular carcinoma, is one of the deadliest cancers worldwide and has a poor prognosis due to insufficient understanding of hepatocarcinogenesis. Previous studies have revealed that ...

Authors: Juanjuan Luo, Chunjiao Lu, Meilan Feng, Lu Dai, Maya Wang, Yang Qiu, Huilu Zheng, Yao Liu, Li Li, Bo Tang, Chuan Xu, Yajun Wang and Xiaojun Yang

FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma

Circular RNAs (circRNAs) are becoming a unique member of non-coding RNAs (ncRNAs) with emerging evidence of their regulatory roles in various cancers. However, with regards to pancreatic ductal adenocarcinoma ...

Authors: Taoyue Yang, Peng Shen, Qun Chen, Pengfei Wu, Hao Yuan, Wanli Ge, Lingdong Meng, Xumin Huang, Yuzhe Fu, Yihan Zhang, Weikang Hu, Yi Miao, Zipeng Lu and Kuirong Jiang

Ethaselen synergizes with oxaliplatin in tumor growth inhibition by inducing ROS production and inhibiting TrxR1 activity in gastric cancer

Oxaliplatin is one of the most commonly used chemotherapeutic agent for the treatment of various cancers, including gastric cancer. It has, however, a narrow therapeutic index due to its toxicity and the occur...

Authors: Haiyong Zhang, Jing Wu, Jinqiu Yuan, Huafu Li, Yawei Zhang, Wang Wu, Wei Chen, Chunming Wang, Sijun Meng, Songyao Chen, Mingyu Huo, Yulong He and Changhua Zhang

SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression

Despite marked advances in the clinical therapies, clinical outcome of most T-cell acute lymphoblastic leukemia (T-ALL) patients remains poor, due to the high risk of relapse, even after complete remission. Pr...

Authors: Fangce Wang, Zheng Li, Jie Zhou, Guangming Wang, Wenjun Zhang, Jun Xu and Aibin Liang

Complement inhibitor CSMD1 modulates epidermal growth factor receptor oncogenic signaling and sensitizes breast cancer cells to chemotherapy

Human CUB and Sushi multiple domains 1 (CSMD1) is a large membrane-bound tumor suppressor in breast cancer. The current study aimed to elucidate the molecular mechanism underlying the effect of CSMD1 in highl...

Authors: Chrysostomi Gialeli, Emre Can Tuysuz, Johan Staaf, Safia Guleed, Veronika Paciorek, Matthias Mörgelin, Konstantinos S. Papadakos and Anna M. Blom

Identification of novel COX-2 / CYP19A1 axis involved in the mesothelioma pathogenesis opens new therapeutic opportunities

Based on previous studies highlighting that the induction of cyclooxygenase-2 (COX-2) and high prostaglandin E2 (PGE2) levels contribute to the pathogenesis of malignant pleural mesothelioma (MPM), and that ar...

Authors: Barbara Nuvoli, Barbara Antoniani, Roberta Libener, Antonio Maconi, Andrea Sacconi, Mariantonia Carosi and Rossella Galati

Altered proTGFα/cleaved TGFα ratios offer new therapeutic strategies in renal carcinoma

Treatment of renal cancer has significantly improved with the arrival to the clinic of kinase inhibitors and immunotherapies. However, the disease is still incurable in advanced stages. The fact that several a...

Authors: Sara García-Alonso, Inés Romero-Pérez, Lucía Gandullo-Sánchez, Luis Chinchilla, Alberto Ocaña, Juan Carlos Montero and Atanasio Pandiella

XPO1/CRM1 is a promising prognostic indicator for neuroblastoma and represented a therapeutic target by selective inhibitor verdinexor

High-risk neuroblastoma patients have a 5-year survival rate of less than 50%. It’s an urgent need to identify new therapeutic targets and the appropriate drugs. Exportin-1 (XPO1), also known as chromosomal re...

Authors: Lijia Pan, Cheng Cheng, Peiwen Duan, Kai Chen, Yeming Wu and Zhixiang Wu

Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma

The incidence of renal cell carcinoma (RCC) is increasing worldwide with an approximate 20% mortality rate. The challenge in RCC is the therapy-resistance. Cancer resistance to treatment employs multiple mecha...

Authors: Fengzhi Li, Ieman A. M. Aljahdali, Renyuan Zhang, Kent L. Nastiuk, John J. Krolewski and Xiang Ling

Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target

Nuclear factor­κB (NF-κB) plays a vital role in hepatocellular carcinoma (HCC). β-arrestin1 (ARRB1) has been proved to enhance the activity of NF-κBp65, and our previous study indicated that ARRB1 promotes hep...

Authors: Xuan Xu, Yiming Lei, Lingjun Chen, Haoxiong Zhou, Huiling Liu, Jie Jiang, Yidong Yang and Bin Wu

Retraction Note: Dual loading miR-218 mimics and Temozolomide using AuCOOH@FA-CS drug delivery system: promising targeted antitumor drug delivery system with sequential release functions

Authors: Li Fan, Qian Yang, Jiali Tan, Youbei Qiao, Qiaofeng Wang, Jingya He, Hong Wu and Yongsheng Zhang

Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target

Pancreatic cancer is a complex disease with a desmoplastic stroma, extreme hypoxia, and inherent resistance to therapy. Understanding the signaling and adaptive response of such an aggressive cancer is key to ...

Authors: Silpa Gampala, Fenil Shah, Xiaoyu Lu, Hye-ran Moon, Olivia Babb, Nikkitha Umesh Ganesh, George Sandusky, Emily Hulsey, Lee Armstrong, Amber L. Mosely, Bumsoo Han, Mircea Ivan, Jing-Ruey Joanna Yeh, Mark R. Kelley, Chi Zhang and Melissa L. Fishel