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  1. Bone metastasis occurs when tumour cells dissociate from primary tumours, enter the circulation (circulating tumour cells, CTCs), and colonize sites in bone (disseminated tumour cells, DTCs). The bone marrow s...

    Authors: Rongchen Dai, Mengfan Liu, Xincheng Xiang, Zhichao Xi and Hongxi Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:316
    Content type: Review Published on:

  2. Tumor-initiating cells (TIC), also known as cancer stem cells, are considered a specific subpopulation of cells necessary for cancer initiation and metastasis; however, the mechanisms by which they acquire met...

    Authors: Donatella Delle Cave, Silvia Buonaiuto, Bruno Sainz Jr, Marco Fantuz, Maria Mangini, Alessandro Carrer, Annalisa Di Domenico, Tea Teresa Iavazzo, Gennaro Andolfi, Carme Cortina, Marta Sevillano, Christopher Heeschen, Vincenza Colonna, Marco Corona, Antonio Cucciardi, Martina Di Guida…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:315
    Content type: Research Published on:

  3. Beta-1,3-galactosyltransferase-4 (B3GALT4) plays a critical regulatory role in tumor biology. However, the role of B3GALT4 in modulating the tumor microenvironment (TME) of neuroblastoma (NB) remains unknown.

    Authors: Yong-Liang Sha, Yun Liu, Jia-Xing Yang, Yang-Yang Wang, Bao-Cheng Gong, Yan Jin, Tong-Yuan Qu, Fan-Tong Xia, Lei Han and Qiang Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:314
    Content type: Research Published on:

  4. Authors: Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang and Jinhong Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:313
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2022 41:284

  5. Cancer-associated fibroblasts (CAFs) are considered to play a fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and chemoresistance. Patient-derived organoids have demonstrated great pote...

    Authors: Sebastian Schuth, Solange Le Blanc, Teresa G. Krieger, Julia Jabs, Miriam Schenk, Nathalia A. Giese, Markus W. Büchler, Roland Eils, Christian Conrad and Oliver Strobel
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:312
    Content type: Research Published on:

  6. Medulloblastoma is the most common malignant pediatric brain tumor and group 3 subtype medulloblastoma (G3-MB) exhibits the worst prognosis. Super enhancers (SEs) are large clusters of enhancers that play impo...

    Authors: Meng Li, Yujie Han, Chaochen Wang, Wenfeng Kang, Wenyan Jiang, Lei Zhang and Yujie Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:311
    Content type: Research Published on:

  7. The HER3 protein, that belongs to the ErbB/HER receptor tyrosine kinase (RTK) family, is expressed in several types of tumors. That fact, together with the role of HER3 in promoting cell proliferation, implica...

    Authors: Lucía Gandullo-Sánchez, Alberto Ocaña and Atanasio Pandiella
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:310
    Content type: Review Published on:

  8. Aberrant activation of the MET receptor in cancer is sustained by genetic alterations or, more frequently, by transcriptional upregulations. A fraction of MET-amplified or mutated tumors are sensible to MET ta...

    Authors: Cristina Chiriaco, Chiara Donini, Marco Cortese, Stefano Ughetto, Chiara Modica, Ilaria Martinelli, Alessia Proment, Letizia Vitali, Lara Fontani, Monica Casucci, Paolo Maria Comoglio, Silvia Giordano, Dario Sangiolo, Valeria Leuci and Elisa Vigna
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:309
    Content type: Research Published on:

  10. Ferroptosis is a novel form of iron-dependent cell death and participates in the malignant progression of glioblastoma (GBM). Although circular RNAs (circRNAs) are found to play key roles in ferroptosis via se...

    Authors: Yang Jiang, Junshuang Zhao, Rongqing Li, Yingliang Liu, Lin Zhou, Chengbin Wang, Caihong Lv, Liang Gao and Daming Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:307
    Content type: Research Published on:

  11. Authors: Chongyang Li, Chaowei Deng, Guangzhao Pan, Xue Wang, Kui Zhang, Zhen Dong, Gaichao Zhao, Mengqin Tan, Xiaosong Hu, Shaomin Shi, Juan Du, Haoyan Ji, Xiaowen Wang, Liqun Yang and Hongjuan Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:306
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:230

  12. Molecular tumor boards (MTBs) match molecular alterations with targeted anticancer drugs upon failure of the available therapeutic options. Special and local needs are most likely to emerge through the compara...

    Authors: Gennaro Ciliberto, Marco Canfora, Irene Terrenato, Chiara Agnoletto, Francesco Agustoni, Loredana Amoroso, Gustavo Baldassarre, Giuseppe Curigliano, Angelo Delmonte, Antonella De Luca, Michelangelo Fiorentino, Vanesa Gregorc, Toni Ibrahim, Chiara Lazzari, Angela Mastronuzzi, Paolo Pronzato…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:305
    Content type: Commentary Published on:

  14. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 expression was reportedly associated with ...

    Authors: Lu Wang, Shuangshuang Li, Huanhua Luo, Qi Lu and Shuwen Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:303
    Content type: Research Published on:

  15. Adenosine is a potent immunosuppressant whose levels in the tumor microenvironment (TME) are often much higher than those in normal tissues. Binding of adenosine to its receptor A2aR activates a cascade of gen...

    Authors: Yu Bai, Xin Zhang, Jie Zheng, Ziyi Liu, Zhenfan Yang and Xiaolin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:302
    Content type: Research Published on:

  16. Early metastasis is a key factor contributing to poor breast cancer (BC) prognosis. Circulating tumor cells (CTCs) are regarded as the precursor cells of metastasis, which are ultimately responsible for the ma...

    Authors: Yufei Long, Tuotuo Chong, Xiaoming Lyu, Lujia Chen, Xiaomin Luo, Oluwasijibomi Damola Faleti, Simin Deng, Fei Wang, Mingliang He, Zhipeng Qian, Hongli Zhao, Wenyan Zhou, Xia Guo, Ceshi Chen and Xin Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:301
    Content type: Research Published on:

  17. Neoadjuvant programmed death receptor-1 (PD-1) inhibitors have drawn increasing attention in locally advanced head and neck squamous cell carcinoma (HNSCC). In this study, we investigated the safety and effica...

    Authors: Xiaotao Huang, Qiaodan Liu, Guihua Zhong, Yingpeng Peng, Ye Liu, Lizhong Liang, Haiyu Hong, Weineng Feng, Shuang Yang, Yaqin Zhang, Shiping Xian, Zhanyu Li, Yuling Zhou, Zhaoyuan Zhang, Wen Jiang, Jun Liang…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:300
    Content type: Research Published on:

  18. Therapeutic strategies engaging the immune system against malignant cells have revolutionized the field of oncology. Proficiency of dendritic cells (DCs) for antigen presentation and immune response has spurre...

    Authors: Natacha Jugniot, Jeremy J. Dahl and Ramasamy Paulmurugan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:299
    Content type: Research Published on:

  19. The introduction of functional in-silico models, in addition to in-vivo tumor models, opens up new and unlimited possibilities in cancer research and drug development. The world's first digital twin of the A54...

    Authors: Christian Baumgartner
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:298
    Content type: Commentary Published on:

  20. Aberrantly activated mammalian target of rapamycin complex 1 (mTORC1) plays a vital role in tumor angiogenesis, but its precise mechanisms are still unclear.

    Authors: Hongwu Li, Ping Liu, Dapeng Li, Zixi Wang, Zhao Ding, Meng Zhou, Xu Chen, Manli Miao, Junli Ding, Wei Lin, Yehai Liu and Xiaojun Zha
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:297
    Content type: Research Published on:

  21. Liver metastasis (LM) is a major obstacle to the prognosis of gastric cancer (GC) patients, but the molecular mechanism underlying gastric cancer liver metastasis (GC-LM) remains unknown. Exosomes have been id...

    Authors: Shengkui Qiu, Li Xie, Chen Lu, Chao Gu, Yiwen Xia, Jialun Lv, Zhe Xuan, Lang Fang, Jing Yang, Lu Zhang, Zheng Li, Weizhi Wang, Hao Xu, Bowen Li and Zekuan Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:296
    Content type: Research Published on:

  22. Although success was achieved in the therapy for a minority of advanced lung adenocarcinoma (LUAD) patients, anti-programmed death 1 (PD1) resistance was found in most LUAD patients. Here, we aimed to uncover ...

    Authors: Jian Gao, Yong-Qiang Ao, Ling-Xian Zhang, Jie Deng, Shuai Wang, Hai-Kun Wang, Jia-Hao Jiang and Jian-Yong Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:295
    Content type: Research Published on:

  23. The family of ten-eleven translocation dioxygenases (TETs) consists of TET1, TET2, and TET3. Although all TETs are expressed in hematopoietic tissues, only TET2 is commonly found to be mutated in age-related clon...

    Authors: Kanak Joshi, Lei Zhang, Peter Breslin S.J., Ameet R. Kini and Jiwang Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:294
    Content type: Review Published on:

  24. Protein arginine methyltransferases (PRMTs) regulate protein biological activity by modulating arginine methylation in cancer and are increasingly recognized as potential drug targets. Inhibitors targeting PRM...

    Authors: Shuangjie Liu, Zhuonan Liu, Chiyuan Piao, Zhe Zhang, Chuize Kong, Lei Yin and Xi Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:293
    Content type: Research Published on:

  25. The management of sub-totally resected sporadic vestibular schwannoma (VS) may include observation, re-resection or irradiation. Identifying the optimal choice can be difficult due to the disease’s variable pr...

    Authors: Moran Amit, Tongxin Xie, Frederico O. Gleber-Netto, Patrick J. Hunt, Gautam U. Mehta, Diana Bell, Deborah A. Silverman, Ismail Yaman, Yi Ye, Jared K. Burks, Gregory N. Fuller, Paul W. Gidley, Marc-Elie Nader, Shaan M. Raza and Franco DeMonte
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:292
    Content type: Research Published on:

  26. Authors: Gangjun Yuan, Xin Chen, Zhuowei Liu, Wensu Wei, Qinghai Shu, Hussein Abou-Hamdan, Lijuan Jiang, Xiangdong Li, Rixin Chen, Laurent Désaubry, Fangjian Zhou and Dan Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:291
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:21

  27. Authors: Barbara Nuvoli, Raffaela Santoro, Simona Catalani, Serafina Battistelli, Serena Benedetti, Franco Canestrari and Rossella Galati
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:290
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2014 33:24

  28. Peptide proteolysis-targeting chimeras (p-PROTACs) with advantages of high specificity and low toxicity have emerged as a powerful technology of targeted protein degradation for biomedical applications. FOXM1,...

    Authors: Kun Wang, Xiaoyong Dai, Albert Yu, Chunyan Feng, Kewei Liu and Laiqiang Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:289
    Content type: Research Published on:

  29. Pancreatic ductal adenocarcinoma is prone to metastasis, resulting in short survival and low quality of life. LncRNAs are pivotal orchestrators that participate in various tumor progress. The underlying role a...

    Authors: Min Zhou, Shutao Pan, Tingting Qin, Chunle Zhao, Taoyuan Yin, Yang Gao, Yuhui Liu, Zhenxiong Zhang, Yongkang Shi, Yu Bai, Jun Gong, Xingjun Guo, Min Wang and Renyi Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:288
    Content type: Research Published on:

  30. Lymph node metastasis is one of most common determinants of the stage and prognosis of gastric cancer (GC). However, the key molecular events and mechanisms mediating lymph node metastasis remain elusive.

    Authors: Yongxu Jia, Qian Yan, Yinli Zheng, Lei Li, Baifeng Zhang, Zhiwei Chang, Zehua Wang, Hong Tang, Yanru Qin and Xin-Yuan Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:287
    Content type: Research Published on:

  31. Extracellular vesicles (EVs) facilitate the extracellular transfer of proteins, lipids, and nucleic acids and mediate intercellular communication among multiple cells in the tumour environment. Small extracell...

    Authors: Kewen Qian, Wenyan Fu, Tian Li, Jian Zhao, Changhai Lei and Shi Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:286
    Content type: Review Published on:

  32. Gasdermin B (GSDMB) over-expression promotes poor prognosis and aggressive behavior in HER2 breast cancer by increasing resistance to therapy. Decoding the molecular mechanism of GSDMB-mediated drug resistance...

    Authors: Manuel Gámez-Chiachio, Ángela Molina-Crespo, Carmen Ramos-Nebot, Jeannette Martinez-Val, Lidia Martinez, Katja Gassner, Francisco J. Llobet, Mario Soriano, Alberto Hernandez, Marco Cordani, Cristina Bernadó-Morales, Eva Diaz, Alejandro Rojo-Sebastian, Juan Carlos Triviño, Laura Sanchez, Ruth Rodríguez-Barrueco…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:285
    Content type: Research Published on:

  33. Oxidative stress is a highly active metabolic process in the liver, that poses great threats to disseminated tumor cells during their colonization. Here, we aimed to investigate how colorectal cancer (CRC) cel...

    Authors: Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang and Jinhong Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:284
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:313

  34. Alternative treatment strategies in melanoma beyond immunotherapy and mutation-targeted therapy are urgently needed. Wild-type isocitrate dehydrogenase 1 (wtIDH1) has recently been implicated as a metabolic de...

    Authors: Mehrdad Zarei, Omid Hajihassani, Jonathan J. Hue, Hallie J. Graor, Alexander W. Loftus, Moeez Rathore, Ali Vaziri-Gohar, John M. Asara, Jordan M. Winter and Luke D. Rothermel
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:283
    Content type: Research Published on:

  35. Adrenocortical cancer (ACC) is a rare and aggressive cancer with dismal 5-year survival due to a lack of effective treatments. We aimed to identify a new effective combination of drugs and investigated their s...

    Authors: Dipranjan Laha, Robert R.C. Grant, Prachi Mishra, Myriem Boufraqech, Min Shen, Ya-Qin Zhang, Matthew D. Hall, Martha Quezado, Michelly Sampaio De Melo, Jaydira Del Rivero, Martha Zeiger and Naris Nilubol
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:282
    Content type: Research Published on:

  36. Circular RNA (circRNA), a new class of non-coding RNA, has obvious correlations with the occurrence and development of many diseases, including tumors. This study aimed to investigate the potential roles of ci...

    Authors: Xiaopei Hao, Yao Zhang, Xiaoli Shi, Hanyuan Liu, Zhiying Zheng, Guoyong Han, Dawei Rong, Chuanyong Zhang, Weiwei Tang and Xuehao Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:281
    Content type: Research Published on:

  38. Immune checkpoint inhibitors (ICI) are approved for treatment of recurrent or metastatic oropharyngeal head and neck squamous cell carcinoma in the first- and second-line settings. However, only 15–20% of pati...

    Authors: Anna Tosi, Beatrice Parisatto, Anna Menegaldo, Giacomo Spinato, Maria Guido, Annarosa Del Mistro, Rossana Bussani, Fabrizio Zanconati, Margherita Tofanelli, Giancarlo Tirelli, Paolo Boscolo-Rizzo and Antonio Rosato
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:279
    Content type: Research Published on:

  39. Epithelial-mesenchymal transition (EMT) is a fundamental process for embryonic development during which epithelial cells acquire mesenchymal characteristics, and the underlying mechanisms confer malignant feat...

    Authors: Hashem Khanbabaei, Saeedeh Ebrahimi, Juan Luis García-Rodríguez, Zahra Ghasemi, Hossein Pourghadamyari, Milad Mohammadi and Lasse Sommer Kristensen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:278
    Content type: Review Published on:

  40. Ovarian cancer (OC) is a heterogeneous malignancy with various etiology, histopathology, and biological feature. Despite accumulating understanding of OC in the post-genomic era, the preclinical knowledge stil...

    Authors: Tianyu Qin, Junpeng Fan, Funian Lu, Li Zhang, Chen Liu, Qiyue Xiong, Yang Zhao, Gang Chen and Chaoyang Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:277
    Content type: Review Published on:

  41. The extracellular matrix (ECM) is an important component of the tumor microenvironment (TME), having several important roles related to the hallmarks of cancer. In cancer, multiple components of the ECM have b...

    Authors: Ancuta Jurj, Calin Ionescu, Ioana Berindan-Neagoe and Cornelia Braicu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:276
    Content type: Review Published on:

  42. Metastasis is a major determinant of death in patients with hepatocellular carcinoma (HCC). Dissecting key molecular mediators that promote this malignant feature may help yield novel therapeutic insights. Her...

    Authors: Tongyue Zhang, Yijun Wang, Meng Xie, Xiaoyu Ji, Xiangyuan Luo, Xiaoping Chen, Bixiang Zhang, Danfei Liu, Yangyang Feng, Mengyu Sun, Wenjie Huang and Limin Xia
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:275
    Content type: Research Published on:

  43. Severe hypoxia is a prominent character of pancreatic ductal adenocarcinoma (PDAC) microenvironment. In the process of gemcitabine based chemotherapy, PDAC cells are insulted from replication stresses co-induc...

    Authors: Qiu Tu, Xiuyun Liu, Xiaoqing Yao, Ruixue Li, Gaojing Liu, Honglv Jiang, Kaiqin Li, Qiongfang Chen, Xiaoyan Huang, Qing Chang, Guoqiang Xu, Hong Zhu, Peng Shi and Bo Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:274
    Content type: Research Published on:

  44. Lamins, key nuclear lamina components, have been proposed as candidate risk biomarkers in different types of cancer but their accuracy is still debated. AKTIP is a telomeric protein with the property of being ...

    Authors: Mattia La Torre, Chiara Merigliano, Klizia Maccaroni, Alexandre Chojnowski, Wah Ing Goh, Maria Giubettini, Fiammetta Vernì, Cristina Capanni, Daniela Rhodes, Graham Wright, Brian Burke, Silvia Soddu, Romina Burla and Isabella Saggio
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:273
    Content type: Research Published on:

  45. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-018-0717-3

    Authors: Zhikui Liu, Yufeng Wang, Changwei Dou, Liankang Sun, Qing Li, Liang Wang, Qiuran Xu, Wei Yang, Qingguang Liu and Kangsheng Tu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:272
    Content type: Retraction Note Published on:

  46. Elesclomol is an anticancer drug that targets mitochondrial metabolism. In the past, elesclomol was recognized as an inducer of oxidative stress, but now it has also been found to suppress cancer by inducing c...

    Authors: Peijie Zheng, Chuntao Zhou, Liuyi Lu, Bin Liu and Yuemin Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:271
    Content type: Review Published on:

  47. Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression and play fundamental roles in various types of cancer. Current developments in transcriptome analyses unveiled the existence...

    Authors: Jiwei Zhang, Tao Pan, Weiwei Zhou, Ya Zhang, Gang Xu, Qi Xu, Si Li, Yueying Gao, Zhengtao Wang, Juan Xu and Yongsheng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:270
    Content type: Research Published on:

  48. Immunotherapy based on Bi-specific T Cell Engagers (TCE) represents one of the most attractive strategy to treat cancers resistant to conventional therapies. TCE are antibody-like proteins that simultaneously ...

    Authors: Margherita Passariello, Asami Yoshioka, Kota Takahashi, Shu-ichi Hashimoto, Toshikazu Inoue, Koji Nakamura and Claudia De Lorenzo
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:269
    Content type: Research Published on:

  49. As our understanding of the mechanisms of cancer treatment has increased, a growing number of studies demonstrate pathways through which DNA damage repair (DDR) affects the immune system. At the same time, the...

    Authors: Congqi Shi, Kaiyu Qin, Anqi Lin, Aimin Jiang, Quan Cheng, Zaoqu Liu, Jian Zhang and Peng Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:268
    Content type: Review Published on:

  50. Circular RNA (circRNA) is crucial to the progression of hepatocellular cancer (HCC). In addition, Mitochondrial calcium uniporter regulatory factor 1 (MCUR1) is commonly overexpressed in HCC to increase cellul...

    Authors: Yi Li, Anqi Wu, Lin Chen, Aiting Cai, Yuhao Hu, Zhou Zhou, Qianyi Qi, Yixuan Wu, Donglin Xia, Peixin Dong, Shaoqing Ju and Feng Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:267
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

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