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  1. Research

    Annexin A2 could enhance multidrug resistance by regulating NF-κB signaling pathway in pediatric neuroblastoma

    Chemotherapy is one of major therapeutic regimens for neuroblastoma (NB) in children. However, recurrence and metastasis associated with poor prognosis caused by acquired multidrug resistance remains a challen...

    Yi Wang, Kai Chen, Yihong Cai, Yuanxia Cai, Xiaojun Yuan, Lifeng Wang, Zhixiang Wu and Yeming Wu

    Journal of Experimental & Clinical Cancer Research 2017 36:111

    Published on: 16 August 2017

  2. Research

    Silencing the Girdin gene enhances radio-sensitivity of hepatocellular carcinoma via suppression of glycolytic metabolism

    Radiotherapy has been used increasingly to treat primary hepatocellular carcinoma. Clinically, the main cause of radiotherapy failure is cellular radioresistance, conferred via glycolytic metabolism. Our previ...

    Li Yu, Yifan Sun, Jingjing Li, Yan Wang, Yuxing Zhu, Yong Shi, Xiaojun Fan, Jianda Zhou, Ying Bao, Jie Xiao, Ke Cao and Peiguo Cao

    Journal of Experimental & Clinical Cancer Research 2017 36:110

    Published on: 15 August 2017

  5. Research

    The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells

    Glioblastoma (GBM) is a highly migratory, invasive, and angiogenic brain tumor. Like vascular endothelial growth factor-A (VEGF-A), placental growth factor (PlGF) promotes GBM angiogenesis. VEGF-A is a ligand ...

    Maria Grazia Atzori, Lucio Tentori, Federica Ruffini, Claudia Ceci, Lucia Lisi, Elena Bonanno, Manuel Scimeca, Eskil Eskilsson, Thomas Daubon, Hrvoje Miletic, Lucia Ricci Vitiani, Roberto Pallini, Pierluigi Navarra, Rolf Bjerkvig, Stefania D’Atri, Pedro Miguel Lacal…

    Journal of Experimental & Clinical Cancer Research 2017 36:106

    Published on: 10 August 2017

  6. Research

    Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2)

    Pancreatic cancer is susceptible to gemcitabine resistance, and patients receive less benefit from gemcitabine chemotherapy. Previous studies report that gambogic acid possesses antineoplastic properties; howe...

    Guanggai Xia, Hongcheng Wang, Ziliang Song, Qingcai Meng, Xiuyan Huang and Xinyu Huang

    Journal of Experimental & Clinical Cancer Research 2017 36:107

    Published on: 10 August 2017

  8. Review

    Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids

    Under hypoxic conditions, tumor cells undergo a series of adaptations that promote evolution of a more aggressive tumor phenotype including the activation of DNA damage repair proteins, altered metabolism, and...

    Stephen Riffle and Rashmi S. Hegde

    Journal of Experimental & Clinical Cancer Research 2017 36:102

    Published on: 3 August 2017

  9. Research

    Wogonoside inhibits invasion and migration through suppressing TRAF2/4 expression in breast cancer

    Twist1 is involved in tumor initiation and progression, which especially contributes to tumor invasion and metastasis. Wogonoside is the main in-vivo metabolite of wogonin, and it is also a natural product wit...

    Yuyuan Yao, Kai Zhao, Zhou Yu, Haochuan Ren, Li Zhao, Zhiyu Li, Qinglong Guo and Na Lu

    Journal of Experimental & Clinical Cancer Research 2017 36:103

    Published on: 3 August 2017

  10. Research

    Epithelial-to-mesenchymal transition in FHC-silenced cells: the role of CXCR4/CXCL12 axis

    Ferritin plays a central role in the intracellular iron metabolism; the molecule is a nanocage of 24 subunits of the heavy and light types. The heavy subunit (FHC) is provided of a ferroxidase activity and thu...

    I. Aversa, F. Zolea, C. Ieranò, S. Bulotta, A. M. Trotta, M. C. Faniello, C. De Marco, D. Malanga, F. Biamonte, G. Viglietto, G. Cuda, S. Scala and F. Costanzo

    Journal of Experimental & Clinical Cancer Research 2017 36:104

    Published on: 3 August 2017

  11. Research

    Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells

    Epidermal growth factor receptor (EGFR) plays a pivotal role in the pathophysiology of esophageal squamous cell carcinoma (ESCC). However, the clinical effects of EGFR inhibitors on ESCC are controversial. Thi...

    Masahiro Yoshioka, Shinya Ohashi, Tomomi Ida, Yukie Nakai, Osamu Kikuchi, Yusuke Amanuma, Junichi Matsubara, Atsushi Yamada, Shin’ichi Miyamoto, Mitsuteru Natsuizaka, Hiroshi Nakagawa, Tsutomu Chiba, Hiroshi Seno and Manabu Muto

    Journal of Experimental & Clinical Cancer Research 2017 36:101

    Published on: 1 August 2017

  12. Research

    Regulation of human glioma cell apoptosis and invasion by miR-152-3p through targeting DNMT1 and regulating NF2

    MiRNAs are involved in aberrant DNA methylation through regulation of DNA methyltransferases (DNMTs) in the pathogenesis and progression of glioblastomas (GBM). MiR-152-3p was down-expressed in human malignanc...

    Jin Sun, Xinhua Tian, Junqing Zhang, Yanlin Huang, Xiaoning Lin, Luyue Chen and Shizhong Zhang

    Journal of Experimental & Clinical Cancer Research 2017 36:100

    Published on: 1 August 2017

  13. Research

    miR-500a-3p promotes cancer stem cells properties via STAT3 pathway in human hepatocellular carcinoma

    miR-500a-3p has been demonstrated to be involved in the development, progression and metastasis in several human cancers. Constitutive activation of JAK/STAT3 signaling pathway has been reported to play an imp...

    Chunlin Jiang, Jianting Long, Baoxian Liu, Ming Xu, Wei Wang, Xiaoyan Xie, Xiaolin Wang and Ming Kuang

    Journal of Experimental & Clinical Cancer Research 2017 36:99

    Published on: 27 July 2017

  14. Review

    Curcumin: the spicy modulator of breast carcinogenesis

    Worldwide breast cancer is the most common cancer in women. For many years clinicians and the researchers are examining and exploring various therapeutic modalities for breast cancer. Yet the disease has remai...

    Urmila Banik, Subramani Parasuraman, Arun Kumar Adhikary and Nor Hayati Othman

    Journal of Experimental & Clinical Cancer Research 2017 36:98

    Published on: 19 July 2017

  16. Research

    Ibrutinib, a Bruton’s tyrosine kinase inhibitor, exhibits antitumoral activity and induces autophagy in glioblastoma

    Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. Ibrutinib, a Bruton’s tyrosine kinase (BTK) inhibitor, is a novel anticancer drug used for treating several types of cancers....

    Jin Wang, Xiaoyang Liu, Yongzhi Hong, Songtao Wang, Pin Chen, Aihua Gu, Xiaoyuan Guo and Peng Zhao

    Journal of Experimental & Clinical Cancer Research 2017 36:96

    Published on: 17 July 2017

  17. Research

    Can recurrences be predicted in craniopharyngiomas? β-catenin coexisting with stem cells markers and p-ATM in a clinicopathologic study of 45cases

    Recurrence is a common feature of craniopharyngiomas, benign tumors that origin from squamous epithelial remnants of Rathke’s pouch- arising at any segment of its whole course. There are two histotypes, showin...

    Elia Guadagno, Oreste de Divitiis, Domenico Solari, Giorgio Borrelli, Umberto Marcello Bracale, Alberto Di Somma, Paolo Cappabianca and Marialaura Del Basso De Caro

    Journal of Experimental & Clinical Cancer Research 2017 36:95

    Published on: 14 July 2017

  18. Erratum

    Erratum to: RERG suppresses cell proliferation, migration and angiogenesis through ERK/NF-κB signaling pathway in nasopharyngeal carcinoma

    Weilin Zhao, Ning Ma, Shumin Wang, Yingxi Mo, Zhe Zhang, Guangwu Huang, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Mariko Murata and Kazuhiko Takeuchi

    Journal of Experimental & Clinical Cancer Research 2017 36:94

    Published on: 13 July 2017

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:88

  19. Research

    Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma by targeting IKKβ kinase activity and interrupting NF-κB/COX-2-mediated signaling cascades

    Glioblastoma multiforme (GBM) is one of the most refractory and palindromic central nervous system (CNS) neoplasms, and current treatments have poor effects in GBM patients. Hence, the identification of novel ...

    Xun Wang, Zhenlong Yu, Chao Wang, Wei Cheng, Xiangge Tian, Xiaokui Huo, Yan Wang, Chengpeng Sun, Lei Feng, Jinshan Xing, Yulong Lan, Dongdong Sun, Qingjuan Hou, Baojing Zhang, Xiaochi Ma and Bo Zhang

    Journal of Experimental & Clinical Cancer Research 2017 36:93

    Published on: 12 July 2017

  20. Research

    Collagen triple helix repeat containing-1 negatively regulated by microRNA-30c promotes cell proliferation and metastasis and indicates poor prognosis in breast cancer

    Collagen triple helix repeat containing-1 (CTHRC1), which was firstly identified overexpressed in the adventitia and neointima of injured rat arteries, could inhibit collagen expression and increase cell migra...

    Yuan-hui Lai, Jian Chen, Xiao-ping Wang, Yan-qing Wu, Hai-tao Peng, Xiao-hong Lin and Wen-jian Wang

    Journal of Experimental & Clinical Cancer Research 2017 36:92

    Published on: 12 July 2017

  21. Research

    In vitro and in vivo cytotoxicity of troglitazone in pancreatic cancer

    Troglitazone (TGZ) is a peroxisome proliferator-activated receptor gamma (PPARγ) agonist that has been investigated as a potential chemopreventive and chemotherapeutic agent. However, the antitumor efficacy an...

    Megumi Fujita, Ai Hasegawa, Motohiro Yamamori and Noboru Okamura

    Journal of Experimental & Clinical Cancer Research 2017 36:91

    Published on: 3 July 2017

  22. Research

    RERG suppresses cell proliferation, migration and angiogenesis through ERK/NF-κB signaling pathway in nasopharyngeal carcinoma

    Nasopharyngeal carcinoma (NPC) is a malignancy of the head and neck that is prevalent in Southeast Asia and southern China. Recent studies in epigenetics suggest that DNA methylation plays a pivotal role in th...

    Weilin Zhao, Ning Ma, Shumin Wang, Yingxi Mo, Zhe Zhang, Guangwu Huang, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Mariko Murata and Kazuhiko Takeuchi

    Journal of Experimental & Clinical Cancer Research 2017 36:88

    Published on: 28 June 2017

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2017 36:94

  23. Research

    Antibody targeting of claudin-1 as a potential colorectal cancer therapy

    Metastatic colorectal cancer (mCRC) is one of the major causes of cancer-related death. Despite the substantial progress in mCRC management, it remains important to identify new therapeutic options and biologi...

    S. Cherradi, A. Ayrolles-Torro, N. Vezzo-Vié, N. Gueguinou, V. Denis, E. Combes, F. Boissière, M. Busson, L. Canterel-Thouennon, C. Mollevi, M. Pugnière, F. Bibeau, M. Ychou, P. Martineau, C. Gongora and M. Del Rio

    Journal of Experimental & Clinical Cancer Research 2017 36:89

    Published on: 28 June 2017

  24. Research

    CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model

    GPRC6A is implicated in the pathogenesis of prostate cancer, but its role remains uncertain because of a purported tolerant gene variant created by substitution of a K..Y polymorphism in the 3rd intracellular ...

    Ruisong Ye, Min Pi, John V. Cox, Satoru K. Nishimoto and L. Darryl Quarles

    Journal of Experimental & Clinical Cancer Research 2017 36:90

    Published on: 28 June 2017

  25. Research

    Induction of endoplasmic reticulum calcium pump expression during early leukemic B cell differentiation

    Endoplasmic reticulum (ER) calcium storage and release play important roles in B lymphocyte maturation, survival, antigen-dependent cell activation and immunoglobulin synthesis. Calcium is accumulated in the e...

    Lamia Aït Ghezali, Atousa Arbabian, Hervé Roudot, Jean-Philippe Brouland, Fanny Baran-Marszak, Evelyn Salvaris, Andrew Boyd, Hans G. Drexler, Agnes Enyedi, Remi Letestu, Nadine Varin-Blank and Bela Papp

    Journal of Experimental & Clinical Cancer Research 2017 36:87

    Published on: 26 June 2017

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