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  1. Research

    TGF-β2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells’ invasion

    Glioblastoma multiforme (GBM) is characterized by lethal aggressiveness and patients with GBM are in urgent need for new therapeutic avenues to improve quality of life. Current studies on tumor invasion focuse...

    Chao Zhang, Xin Zhang, Ran Xu, Bin Huang, An-Jing Chen, Chao Li, Jian Wang and Xin-Gang Li

    Journal of Experimental & Clinical Cancer Research 2017 36:162

    Published on: 16 November 2017

  2. Research

    Downregulation of MiR-31 stimulates expression of LATS2 via the hippo pathway and promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma

    Dysregulation of miRNAs is associated with cancer development by coordinately suppressing abundant target genes. Emerging evidence indicates that miR-31 plays a dual role in tumorigenicity. However, whether mi...

    Yanping Gao, Jun Yi, Kai Zhang, Fan Bai, Bing Feng, Rui Wang, Xiaoyuan Chu, Longbang Chen and Haizhu Song

    Journal of Experimental & Clinical Cancer Research 2017 36:161

    Published on: 16 November 2017

  3. Research

    Patient-derived xenograft in zebrafish embryos: a new platform for translational research in gastric cancer

    Gastric cancer (GC) is among the most commonly cancer occurred in Asian, especially in China. With its high heterogeneity and few of validated drug targets, GC remains to be one of the most under explored area...

    Jia-Qi Wu, Jing Zhai, Chong-Yong Li, Ai-Min Tan, Ping Wei, Li-Zong Shen and Ming-Fang He

    Journal of Experimental & Clinical Cancer Research 2017 36:160

    Published on: 15 November 2017

  4. Research

    Involvement of aberrantly activated HOTAIR/EZH2/miR-193a feedback loop in progression of prostate cancer

    Though androgen deprivation therapy is the standard treatment for prostate cancer (PCa), most patients would inevitably progress to castration-resistant prostate cancer (CRPC) which is the main cause of PCa de...

    Zhixin Ling, Xiaoyan Wang, Tao Tao, Lei Zhang, Han Guan, Zonghao You, Kai Lu, Guangyuan Zhang, Shuqiu Chen, Jianping Wu, Jinke Qian, Hui Liu, Bin Xu and Ming Chen

    Journal of Experimental & Clinical Cancer Research 2017 36:159

    Published on: 15 November 2017

  5. Research

    MiR-361-5p inhibits glycolytic metabolism, proliferation and invasion of breast cancer by targeting FGFR1 and MMP-1

    MicroRNAs function as key regulators in various human cancers, including breast cancer (BC). MiR-361-5p has been proved to be a tumor suppressor in colorectal cancer and gastric cancer in our previous study. I...

    Fei Ma, Lei Zhang, Li Ma, Yiyun Zhang, Jianguo Zhang and Baoliang Guo

    Journal of Experimental & Clinical Cancer Research 2017 36:158

    Published on: 13 November 2017

  6. Research

    CLDN6 promotes chemoresistance through GSTP1 in human breast cancer

    Claudin-6 (CLDN6), a member of CLDN family and a key component of tight junction, has been reported to function as a tumor suppressor in breast cancer. However, whether CLDN6 plays any role in breast cancer ch...

    Minlan Yang, Yanru Li, Xiangfeng Shen, Yang Ruan, Yan Lu, Xiangshu Jin, Peiye Song, Yantong Guo, Xiaoli Zhang, Huinan Qu, Yijia Shao and Chengshi Quan

    Journal of Experimental & Clinical Cancer Research 2017 36:157

    Published on: 7 November 2017

  7. Research

    TAGLN2 is a candidate prognostic biomarker promoting tumorigenesis in human gliomas

    Transgelin-2 (TAGLN2) is a member of the calponin family of actin-bundling proteins that is involved in the regulation of cell morphology, motility, and cell transformation. Here, the clinical significance and...

    Ming-Zhi Han, Ran Xu, Yang-Yang Xu, Xin Zhang, Shi-Lei Ni, Bin Huang, An-Jing Chen, Yu-Zhen Wei, Shuai Wang, Wen-Jie Li, Qing Zhang, Gang Li, Xin-Gang Li and Jian Wang

    Journal of Experimental & Clinical Cancer Research 2017 36:155

    Published on: 6 November 2017

  8. Research

    Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2+ breast cancer cells

    ERBB2 is overexpressed in up to 20–30% of human breast cancers (BCs), and it is associated with aggressive disease. Trastuzumab (Tz), a humanized monoclonal antibody, improves the prognosis associated with ERB...

    Carolina D’Alesio, Grazia Bellese, Maria Cristina Gagliani, Cinzia Aiello, Elena Grasselli, Gianluca Marcocci, Angela Bisio, Sara Tavella, Tiziana Daniele, Katia Cortese and Patrizio Castagnola

    Journal of Experimental & Clinical Cancer Research 2017 36:154

    Published on: 3 November 2017

  9. Research

    Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling

    Clinically, breast cancer is generally classified into estrogen receptor-positive (ER+) or estrogen receptor-negative (ER−) subtypes. The phytoestrogen calycosin has been shown to inhibit the proliferation of ...

    Jing Tian, Yong Wang, Xing Zhang, Qianyao Ren, Rong Li, Yue Huang, Huiling Lu and Jian Chen

    Journal of Experimental & Clinical Cancer Research 2017 36:153

    Published on: 2 November 2017

  10. Review

    Circular RNAs: emerging cancer biomarkers and targets

    CircRNAs are a class of RNA molecules that structurally form closed loops. CircRNAs are abundant in eukaryotic transcripts and show certain levels of tissue and cell specificity. CircRNAs have been suggested t...

    Yu Zhang, Wei Liang, Peng Zhang, Jingyan Chen, Hui Qian, Xu Zhang and Wenrong Xu

    Journal of Experimental & Clinical Cancer Research 2017 36:152

    Published on: 2 November 2017

  11. Research

    Synthetic regulatory RNAs selectively suppress the progression of bladder cancer

    The traditional treatment for cancer is lack of specificity and efficacy. Modular synthetic regulatory RNAs, such as inhibitive RNA (iRNA) and active RNA (aRNA), may overcome these limitations. Here, we synthe...

    Chengle Zhuang, Xinbo Huang, Changshui Zhuang, Xiaomin Luo, Xiaowei Zhang, Zhiming Cai and Yaoting Gui

    Journal of Experimental & Clinical Cancer Research 2017 36:151

    Published on: 30 October 2017

  12. Research

    Musashi-2, a novel oncoprotein promoting cervical cancer cell growth and invasion, is negatively regulated by p53-induced miR-143 and miR-107 activation

    Although previous studies have shown promise for targeting Musashi RNA-binding protein 2 (MSI-2) in diverse tumors, the role and mechanism of MSI-2 for cervical cancer (CC) progression and the regulation of MS...

    Peixin Dong, Ying Xiong, Sharon J. B. Hanley, Junming Yue and Hidemichi Watari

    Journal of Experimental & Clinical Cancer Research 2017 36:150

    Published on: 26 October 2017

  13. Research

    PTEN expression is upregulated by a RNA-binding protein RBM38 via enhancing its mRNA stability in breast cancer

    PTEN (phosphatase and tensin homolog gene on chromosome 10), a well-characterized tumor suppressor, is a key regulator of the phosphatidylinositol-3-kinase (PI3K)/AKT pathway involved in cell survival, metasta...

    Xu-Jie Zhou, Jing Wu, Liang Shi, Xiao-Xia Li, Lei Zhu, Xi Sun, Jia-Yi Qian, Ying Wang, Ji-Fu Wei and Qiang Ding

    Journal of Experimental & Clinical Cancer Research 2017 36:149

    Published on: 19 October 2017

  14. Research

    Upregulation of DARS2 by HBV promotes hepatocarcinogenesis through the miR-30e-5p/MAPK/NFAT5 pathway

    Infection with the hepatitis B virus (HBV) is closely associated with the development of hepatocellular carcinoma (HCC). The osmoregulatory transcription factor nuclear factor of activated T-cells 5 (NFAT5) ha...

    Xian Qin, Changsheng Li, Tao Guo, Jing Chen, Hai-Tao Wang, Yi-Tao Wang, Yu-Sha Xiao, Jun Li, Pengpeng Liu, Zhi-Su Liu and Quan-Yan Liu

    Journal of Experimental & Clinical Cancer Research 2017 36:148

    Published on: 19 October 2017

  15. Research

    Epigenetic mediated zinc finger protein 671 downregulation promotes cell proliferation and tumorigenicity in nasopharyngeal carcinoma by inhibiting cell cycle arrest

    Epigenetic abnormalities play important roles in nasopharyngeal cancer (NPC), however, the epigenetic changes associated with abnormal cell proliferation remain unclear.

    Jian Zhang, Xin Wen, Na Liu, Ying-Qin Li, Xin-Ran Tang, Ya-Qin Wang, Qing-Mei He, Xiao-Jing Yang, Pan-Pan Zhang, Jun Ma and Ying Sun

    Journal of Experimental & Clinical Cancer Research 2017 36:147

    Published on: 19 October 2017

  16. Research

    PAK5-mediated phosphorylation and nuclear translocation of NF-κB-p65 promotes breast cancer cell proliferation in vitro and in vivo

    Abnormal proliferation is significantly associated with the promotion of malignant tumor. Growing evidence suggest that the signal pathways of p21cdc42/rac1-activated kinase 5 (PAK5) have been found in various tu...

    Ying-Chun Zhang, Fu-Chun Huo, Lu-Lu Wei, Chan-Chan Gong, Yao-Jie Pan, Jie Mou and Dong-Sheng Pei

    Journal of Experimental & Clinical Cancer Research 2017 36:146

    Published on: 17 October 2017

  17. Research

    YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4), a dual YAP/COX-2 inhibitor, overcomes drug resistance in colorectal cancer

    Chemotherapy resistance remains a major challenge in cancer treatment. COX-2 (cyclooxygenase 2) is involved in drug resistance and poor prognosis of many neoplastic diseases or cancers. However, investigations...

    Wei Li, Yuanyuan Cao, Jinling Xu, Ying Wang, Weijie Li, Qian Wang, Ziwei Hu, Yaping Hao, Li Hu, Yawen Sun, Guanglin Xu and Guizhen Ao

    Journal of Experimental & Clinical Cancer Research 2017 36:144

    Published on: 16 October 2017

  18. Research

    circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a

    Accumulating evidences indicate that circular RNAs (circRNAs), a class of non-coding RNAs, play important roles in tumorigenesis. However, the function of circRNAs in triple negative breast cancer (TNBC) is la...

    Rongfang He, Peng Liu, Xiaoming Xie, Yujuan Zhou, Qianjin Liao, Wei Xiong, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng and Hailin Tang

    Journal of Experimental & Clinical Cancer Research 2017 36:145

    Published on: 16 October 2017

  19. Research

    Breast carcinomas with low amplified/equivocal HER2 by Ish: potential supporting role of multiplex ligation-dependent probe amplification

    This is a retrospective cross sectional study aimed to verify whether Multiplex Ligation-dependent Probe Amplification (MLPA), a quantitative molecular assay, may represent a valuable reflex test in breast can...

    Cristiana Ercolani, Caterina Marchiò, Anna Di Benedetto, Alessandra Fabi, Letizia Perracchio, Patrizia Vici, Francesca Sperati, Simonetta Buglioni, Vincenzo Arena, Edoardo Pescarmona, Anna Sapino, Irene Terrenato and Marcella Mottolese

    Journal of Experimental & Clinical Cancer Research 2017 36:143

    Published on: 13 October 2017

  20. Research

    SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis

    Our previous studies reported that SHC SH2-domain binding protein 1 (SHCBP1) functions as an oncogene via promoting cell proliferations in synovial sarcoma (SS) cells. However, whether SHCBP1 has any effect on...

    Changliang Peng, Hui Zhao, Yan Song, Wei Chen, Xiaoying Wang, Xiaoli Liu, Cheng Zhang, Jie Zhao, Ji Li, Guanghui Cheng, Dongjin Wu, Chunzheng Gao and Xiuwen Wang

    Journal of Experimental & Clinical Cancer Research 2017 36:141

    Published on: 11 October 2017

  21. Research

    The α-melanocyte stimulating hormone/peroxisome proliferator activated receptor-γ pathway down-regulates proliferation in melanoma cell lines

    The α-Melanocyte Stimulating Hormone (αMSH)/Melanocortin-1 receptor (MC1R) interaction promotes melanogenesis through the cAMP/PKA pathway. The direct induction of this pathway by Forskolin (FSK) is also known...

    Enrica Flori, Eleonora Rosati, Giorgia Cardinali, Daniela Kovacs, Barbara Bellei, Mauro Picardo and Vittoria Maresca

    Journal of Experimental & Clinical Cancer Research 2017 36:142

    Published on: 11 October 2017

  22. Research

    IL-27 mediates HLA class I up-regulation, which can be inhibited by the IL-6 pathway, in HLA-deficient Small Cell Lung Cancer cells

    Recently, immunotherapy with anti-PD-1 antibodies has shown clinical benefit in recurrent Small Cell Lung Cancer (SCLC). Since anti-PD-1 re-activates anti-tumor Cytotoxic T Lymphocyte (CTL) responses, it is cr...

    Grazia Carbotti, Amin Reza Nikpoor, Paola Vacca, Rosaria Gangemi, Chiara Giordano, Francesco Campelli, Silvano Ferrini and Marina Fabbi

    Journal of Experimental & Clinical Cancer Research 2017 36:140

    Published on: 11 October 2017

  23. Research

    Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway

    Prostate cancer (PCa) is one of the most frequent tumors and leading cause of cancer deaths among males worldwide. The majority of deaths are due to recurrence and subsequent development of the metastatic canc...

    Pei-Jie Zhou, Wei Xue, Jinliang Peng, Yanqing Wang, Lianzi Wei, Ziqiang Yang, Helen He Zhu, Yu-Xiang Fang and Wei-Qiang Gao

    Journal of Experimental & Clinical Cancer Research 2017 36:139

    Published on: 10 October 2017

  24. Research

    MiR-203a-3p suppresses cell proliferation and metastasis through inhibiting LASP1 in nasopharyngeal carcinoma

    miR-203a-3p was reported as a tumor suppressor and disregulated in many malignancies including nasopharyngeal carcinoma (NPC). However, its function in tumor growth and metastasis in NPC has rarely been reported.

    Ning Jiang, Xuesong Jiang, Zhenzhang Chen, Xue Song, Lirong Wu, Dan Zong, Dan Song, Li Yin, Dejun Wang, Cheng Chen, Xiuhua Bian and Xia He

    Journal of Experimental & Clinical Cancer Research 2017 36:138

    Published on: 5 October 2017

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