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  1. Content type: Review

    Cancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the bulk of tumor cells, CSCs or TICs are refrac...

    Authors: Mei Yi, Junjun Li, Shengnan Chen, Jing Cai, Yuanyuan Ban, Qian Peng, Ying Zhou, Zhaoyang Zeng, Shuping Peng, Xiaoling Li, Wei Xiong, Guiyuan Li and Bo Xiang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:118

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  2. Content type: Research

    Increasing evidence reveals a significant correlation between gamma-synuclein (SNCG) level and tumor invasion and metastasis in various human cancers. Our previous investigation showed that SNCG could secrete ...

    Authors: Caiyun Liu, Like Qu, Chuanke Zhao and Chengchao Shou

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:117

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  3. Content type: Research

    Many tripartite motif (TRIM) family proteins have been reported to be of great importance in the initiation and progression in hepatocellular carcinoma (HCC). However, the biological role and regulatory mechan...

    Authors: Yi Zhang, Ran Tao, Shan-Shan Wu, Cui-Cui Xu, Jie-Ling Wang, Jie Chen, Yong-Sheng Yu, Zheng-Hao Tang, Xiao-Hua Chen and Guo-Qing Zang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:116

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  4. Content type: Research

    To test the hypothesis that activated extracellular signal-regulated kinase (ERK) regulates P65-miR23a/27a/24 axis in gastric cancer (GC) and the ERK-P65-miR23a/27a/24 axis plays an important role in the devel...

    Authors: Li-Dong Zu, Xing-Chun Peng, Zhi Zeng, Jing-Long Wang, Li-Li Meng, Wei-Wei Shen, Chun-Ting Hu, Ye Yang and Guo-Hui Fu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:115

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  5. Content type: Research

    Angiogenesis is considered as an important process in the development of malignancies and is associated with cancer progression and metastasis. Hepatocellular carcinoma (HCC) is the most common primary tumor o...

    Authors: Jinduan Lin, Shunwang Cao, Yu Wang, Yanwei Hu, Hongwei Liu, Jiehua Li, Jing Chen, Pan Li, Jumei Liu, Qian Wang and Lei Zheng

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:113

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  6. Content type: Research

    Tetrandrine, a bisbenzylisoquinoline alkaloid that was isolated from the medicinal plant Stephania tetrandrine S. Moore, was recently identified as a novel chemotherapy drug. Tetrandrine exhibited a potential ant...

    Authors: Man Yu, Ting Liu, Yicheng Chen, Yafang Li and Wenhua Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:114

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  7. Content type: Correction

    In the publication of this article [1], there is an error in Fig. 7. The minus and plus signals are inverted which impairs understanding of the results described.

    Authors: Duarte Mendes Oliveira, Katia Grillone, Chiara Mignogna, Valentina De Falco, Carmelo Laudanna, Flavia Biamonte, Rosa Locane, Francesco Corcione, Massimiliano Fabozzi, Rosario Sacco, Giuseppe Viglietto, Donatella Malanga and Antonia Rizzuto

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:112

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    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:84

  8. Content type: Research

    The expression of desmosomal genes in lung adenocarcinoma and lung squamous carcinoma is different. However, the regulatory mechanism of desmosomal gene expression in lung adenocarcinoma and lung squamous carc...

    Authors: Xianglin Hao, Fei Han, Bangjin Ma, Ning Zhang, Hongqiang Chen, Xiao Jiang, Li Yin, Wenbin Liu, Lin Ao, Jia Cao and Jinyi Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:111

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  9. Content type: Review

    Immune checkpoints include stimulatory and inhibitory checkpoint molecules. In recent years, inhibitory checkpoints, including cytotoxic T lymphocyte–associated antigen 4 (CTLA-4), programmed cell death protei...

    Authors: Feng Xu, Tianqiang Jin, Yuwen Zhu and Chaoliu Dai

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:110

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  10. Content type: Research

    Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide and has poor prognosis. Specially, patients with HCC usually have poor tolerance of systemic chemotherapy, because HCCs devel...

    Authors: Yeonhwa Song, Jin-Sun Kim, Se-Hyuk Kim, Yoon Kyung Park, Eunsil Yu, Ki-Hun Kim, Eul-Ju Seo, Heung-Bum Oh, Han Chu Lee, Kang Mo Kim and Haeng Ran Seo

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:109

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  11. Content type: Correction

    In the publication of this article [1], there was an error in Figs. 2, 3 and 6.

    Authors: Bao-Xia Li, Heng-Bang Wang, Miao-Zhen Qiu, Qiu-Yun Luo, Han-Jie Yi, Xiang-Lei Yan, Wen-Tao Pan, Lu-Ping Yuan, Yu-Xin Zhang, Jian-Hua Xu, Lin Zhang and Da-Jun Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:108

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    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:53

  12. Content type: Research

    PARP1 facilitates the recovery of DNA-damaged cells by recruiting DNA damage response molecules such as γH2AX and BRCA1/2, and plays a role in resistance to antitumor therapies. Therefore, PARP inhibition bein...

    Authors: Hye Jeong Park, Jun Sang Bae, Kyoung Min Kim, Young Jae Moon, See-Hyoung Park, Sang Hoon Ha, Usama Khamis Hussein, Zhongkai Zhang, Ho Sung Park, Byung-Hyun Park, Woo Sung Moon, Jung Ryul Kim and Kyu Yun Jang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:107

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  13. Content type: Research

    LncRNA TUG1 has been reported to be highly expressed in CRC samples and cells and promoted metastasis by affecting EMT, indicating a poor prognosis for colorectal cancer (CRC). In this study, we determined the...

    Authors: Junfeng Sun, Jiyi Hu, Guojun Wang, Zhen Yang, Chunlin Zhao, Xiefu Zhang and Jiaxiang Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:106

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  14. Content type: Research

    Liver tumor initiating cells (TICs) have self-renewal and differentiate capacities, and largely contribute to tumor initiation, metastasis and drug resistance. MAPK signaling is a critical pathway in many biol...

    Authors: Guanqun Huang, Hui Jiang, Yueming He, Ye Lin, Wuzheng Xia, Yuanwei Luo, Min Liang, Boyun Shi, Xinke Zhou and Zhixiang Jian

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:105

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  15. Content type: Research

    Great progress has been achieved in the study of the aerobic glycolysis or the so-called Warburg effect in a variety of cancers; however, the regulation of the Warburg effect in Nasopharyngeal carcinoma (NPC) ...

    Authors: Cheng-fu Cai, Guo-dong Ye, Dong-yan Shen, Wei Zhang, Mao-li Chen, Xin-xin Chen, Da-xiong Han, Yan-jun Mi, Qi-cong Luo, Wang-yu Cai and Shu-yu Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:104

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  16. Content type: Research

    The signal transducer and activator of transcription (STAT) and transforming growth factor-β (TGF-β) signaling pathways play important roles in epithelial ovarian cancer (EOC). However, the mechanism of crosst...

    Authors: Xiaoling Tian, Wencai Guan, Lingyun Zhang, Wenwen Sun, Daibing Zhou, Qunbo Lin, Weimin Ren, Lubna Nadeem and Guoxiong Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:103

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  17. Content type: Research

    Aberrant hypermethylation of cellular genes is a common phenomenon to inactivate genes and promote tumorigenesis in nasopharyngeal carcinoma (NPC).

    Authors: Hsin-Pai Li, Chen-Ching Peng, Chih-Ching Wu, Chien-Hsun Chen, Meng-Jhe Shih, Mei-Yuan Huang, Yi-Ru Lai, Yung-Li Chen, Ting-Wen Chen, Petrus Tang, Yu-Sun Chang, Kai-Ping Chang and Cheng-Lung Hsu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:102

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  18. Content type: Review

    Transfer RNAs (tRNAs), traditionally considered to participate in protein translation, were interspersed in the entire genome. Recent studies suggested that dysregulation was observed in not only tRNAs, but al...

    Authors: Shi-qiong Huang, Bao Sun, Zong-ping Xiong, Yan Shu, Hong-hao Zhou, Wei Zhang, Jing Xiong and Qing Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:101

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  19. Content type: Research

    Spindlin1 (SPIN1), a protein highly expressed in several human cancers, has been correlated with tumorigenesis and development. Alterations of drug metabolizing enzymes and drug transporters are major determin...

    Authors: Xu Chen, Ya-Wen Wang and Peng Gao

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:100

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  20. Content type: Research

    Higher matrix stiffness affects biological behavior of tumor cells, regulates tumor-associated gene/miRNA expression and stemness characteristic, and contributes to tumor invasion and metastasis. However, the ...

    Authors: Sifan Wu, Qiongdan Zheng, Xiaoxia Xing, Yinying Dong, Yaohui Wang, Yang You, Rongxin Chen, Chao Hu, Jie Chen, Dongmei Gao, Yan Zhao, Zhiming Wang, Tongchun Xue, Zhenggang Ren and Jiefeng Cui

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:99

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  21. Content type: Research

    A35 is a novel synthetic cyclizing-berberine recently patented as an antitumor compound. Based on its dual targeting topoisomerase (top) activity, A35 might overcome the resistance of single-target top inhibit...

    Authors: Wuli Zhao, Hong Liu, Junxia Wang, Mengyan Wang and Rongguang Shao

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:98

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  22. Content type: Research

    Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of tumors, with aggressive clinical course that renders prognostication and choice of treatment strategy difficult. Chemo-immunotherapy with ritux...

    Authors: Francesco Marchesi, Giulia Regazzo, Francesca Palombi, Irene Terrenato, Andrea Sacconi, Manuela Spagnuolo, Sara Donzelli, Mirella Marino, Cristiana Ercolani, Anna Di Benedetto, Giovanni Blandino, Gennaro Ciliberto, Andrea Mengarelli and Maria Giulia Rizzo

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:95

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  23. Content type: Research

    MicroRNA (miRNAs) are non-coding small RNA molecules that regulate gene expression by inhibiting the translation of target mRNAs. Among several dysregulated miRNAs in human cancer, the up-regulation of miR-221...

    Authors: Maria Francesca Santolla, Rosamaria Lappano, Francesca Cirillo, Damiano Cosimo Rigiracciolo, Anna Sebastiani, Sergio Abonante, Pierfrancesco Tassone, Pierosandro Tagliaferri, Maria Teresa Di Martino, Marcello Maggiolini and Adele Vivacqua

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:94

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  24. Content type: Research

    Tumor microenvironment (TME) includes many factors such as tumor associated inflammatory cells, vessels, and lymphocytes, as well as different signaling molecules and extracellular matrix components. These asp...

    Authors: Concetta Saponaro, Alessandro Vagheggini, Emanuela Scarpi, Matteo Centonze, Ivana Catacchio, Ondina Popescu, Maria Irene Pastena, Francesco Giotta, Nicola Silvestris and Anita Mangia

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:96

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  25. Content type: Research

    Gastric cancer is the leading cause of cancer related death worldwide. Radiation alone or combined with chemotherapy plays important role in locally advanced and metastatic gastric adenocarcinoma. MDM2–p53 int...

    Authors: Hanjie Yi, Xianglei Yan, Qiuyun Luo, Luping Yuan, Baoxia Li, Wentao Pan, Lin Zhang, Haibo Chen, Jing Wang, Yubin Zhang, Yifan Zhai, Miao-Zhen Qiu and Da-Jun Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:97

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Page 1 of 61

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