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  1. Review

    Curcumin: the spicy modulator of breast carcinogenesis

    Worldwide breast cancer is the most common cancer in women. For many years clinicians and the researchers are examining and exploring various therapeutic modalities for breast cancer. Yet the disease has remai...

    Urmila Banik, Subramani Parasuraman, Arun Kumar Adhikary and Nor Hayati Othman

    Journal of Experimental & Clinical Cancer Research 2017 36:98

    Published on: 19 July 2017

  2. Research

    Ibrutinib, a Bruton’s tyrosine kinase inhibitor, exhibits antitumoral activity and induces autophagy in glioblastoma

    Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. Ibrutinib, a Bruton’s tyrosine kinase (BTK) inhibitor, is a novel anticancer drug used for treating several types of cancers....

    Jin Wang, Xiaoyang Liu, Yongzhi Hong, Songtao Wang, Pin Chen, Aihua Gu, Xiaoyuan Guo and Peng Zhao

    Journal of Experimental & Clinical Cancer Research 2017 36:96

    Published on: 17 July 2017

  3. Research

    Can recurrences be predicted in craniopharyngiomas? β-catenin coexisting with stem cells markers and p-ATM in a clinicopathologic study of 45cases

    Recurrence is a common feature of craniopharyngiomas, benign tumors that origin from squamous epithelial remnants of Rathke’s pouch- arising at any segment of its whole course. There are two histotypes, showin...

    Elia Guadagno, Oreste de Divitiis, Domenico Solari, Giorgio Borrelli, Umberto Marcello Bracale, Alberto Di Somma, Paolo Cappabianca and Marialaura Del Basso De Caro

    Journal of Experimental & Clinical Cancer Research 2017 36:95

    Published on: 14 July 2017

  4. Erratum

    Erratum to: RERG suppresses cell proliferation, migration and angiogenesis through ERK/NF-κB signaling pathway in nasopharyngeal carcinoma

    Weilin Zhao, Ning Ma, Shumin Wang, Yingxi Mo, Zhe Zhang, Guangwu Huang, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Mariko Murata and Kazuhiko Takeuchi

    Journal of Experimental & Clinical Cancer Research 2017 36:94

    Published on: 13 July 2017

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:88

  5. Research

    Collagen triple helix repeat containing-1 negatively regulated by microRNA-30c promotes cell proliferation and metastasis and indicates poor prognosis in breast cancer

    Collagen triple helix repeat containing-1 (CTHRC1), which was firstly identified overexpressed in the adventitia and neointima of injured rat arteries, could inhibit collagen expression and increase cell migra...

    Yuan-hui Lai, Jian Chen, Xiao-ping Wang, Yan-qing Wu, Hai-tao Peng, Xiao-hong Lin and Wen-jian Wang

    Journal of Experimental & Clinical Cancer Research 2017 36:92

    Published on: 12 July 2017

  6. Research

    Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma by targeting IKKβ kinase activity and interrupting NF-κB/COX-2-mediated signaling cascades

    Glioblastoma multiforme (GBM) is one of the most refractory and palindromic central nervous system (CNS) neoplasms, and current treatments have poor effects in GBM patients. Hence, the identification of novel ...

    Xun Wang, Zhenlong Yu, Chao Wang, Wei Cheng, Xiangge Tian, Xiaokui Huo, Yan Wang, Chengpeng Sun, Lei Feng, Jinshan Xing, Yulong Lan, Dongdong Sun, Qingjuan Hou, Baojing Zhang, Xiaochi Ma and Bo Zhang

    Journal of Experimental & Clinical Cancer Research 2017 36:93

    Published on: 12 July 2017

  7. Research

    In vitro and in vivo cytotoxicity of troglitazone in pancreatic cancer

    Troglitazone (TGZ) is a peroxisome proliferator-activated receptor gamma (PPARγ) agonist that has been investigated as a potential chemopreventive and chemotherapeutic agent. However, the antitumor efficacy an...

    Megumi Fujita, Ai Hasegawa, Motohiro Yamamori and Noboru Okamura

    Journal of Experimental & Clinical Cancer Research 2017 36:91

    Published on: 3 July 2017

  8. Research

    CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model

    GPRC6A is implicated in the pathogenesis of prostate cancer, but its role remains uncertain because of a purported tolerant gene variant created by substitution of a K..Y polymorphism in the 3rd intracellular ...

    Ruisong Ye, Min Pi, John V. Cox, Satoru K. Nishimoto and L. Darryl Quarles

    Journal of Experimental & Clinical Cancer Research 2017 36:90

    Published on: 28 June 2017

  9. Research

    Antibody targeting of claudin-1 as a potential colorectal cancer therapy

    Metastatic colorectal cancer (mCRC) is one of the major causes of cancer-related death. Despite the substantial progress in mCRC management, it remains important to identify new therapeutic options and biologi...

    S. Cherradi, A. Ayrolles-Torro, N. Vezzo-Vié, N. Gueguinou, V. Denis, E. Combes, F. Boissière, M. Busson, L. Canterel-Thouennon, C. Mollevi, M. Pugnière, F. Bibeau, M. Ychou, P. Martineau, C. Gongora and M. Del Rio

    Journal of Experimental & Clinical Cancer Research 2017 36:89

    Published on: 28 June 2017

  10. Research

    RERG suppresses cell proliferation, migration and angiogenesis through ERK/NF-κB signaling pathway in nasopharyngeal carcinoma

    Nasopharyngeal carcinoma (NPC) is a malignancy of the head and neck that is prevalent in Southeast Asia and southern China. Recent studies in epigenetics suggest that DNA methylation plays a pivotal role in th...

    Weilin Zhao, Ning Ma, Shumin Wang, Yingxi Mo, Zhe Zhang, Guangwu Huang, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Mariko Murata and Kazuhiko Takeuchi

    Journal of Experimental & Clinical Cancer Research 2017 36:88

    Published on: 28 June 2017

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2017 36:94

  11. Research

    Induction of endoplasmic reticulum calcium pump expression during early leukemic B cell differentiation

    Endoplasmic reticulum (ER) calcium storage and release play important roles in B lymphocyte maturation, survival, antigen-dependent cell activation and immunoglobulin synthesis. Calcium is accumulated in the e...

    Lamia Aït Ghezali, Atousa Arbabian, Hervé Roudot, Jean-Philippe Brouland, Fanny Baran-Marszak, Evelyn Salvaris, Andrew Boyd, Hans G. Drexler, Agnes Enyedi, Remi Letestu, Nadine Varin-Blank and Bela Papp

    Journal of Experimental & Clinical Cancer Research 2017 36:87

    Published on: 26 June 2017

  12. Research

    HOXB7 accelerates the malignant progression of hepatocellular carcinoma by promoting stemness and epithelial-mesenchymal transition

    Homeobox B7 (HOXB7) has been identified associated with poor prognosis of hepatocellular carcinoma (HCC). However, the specific mechanism by which HOXB7 promotes the malignant progression of HCC remains to be ...

    Hong-bo Huan, Da-peng Yang, Xu-dong Wen, Xue-jiao Chen, Liang Zhang, Li-li Wu, Ping Bie and Feng Xia

    Journal of Experimental & Clinical Cancer Research 2017 36:86

    Published on: 24 June 2017

  13. Research

    High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation

    Oesophageal cancer is one of the most common malignancies worldwide,and oesophageal squamous cell carcinoma (ESCC) is the predominant histological type both globally and in China. Collagen triple helix repeat ...

    Chunni Wang, Zitong Li, Fei Shao, Xueying Yang, Xiaoli Feng, Susheng Shi, Yibo Gao and Jie He

    Journal of Experimental & Clinical Cancer Research 2017 36:84

    Published on: 23 June 2017

  14. Research

    PHF21B overexpression promotes cancer stem cell-like traits in prostate cancer cells by activating the Wnt/β-catenin signaling pathway

    PHF21B is newly identified to be involved in the tumor progression; however, its biological role and molecular mechanism in prostate cancer have not been defined. This study is aimed to study the role of PHF21...

    Qiji Li, Liping Ye, Wei Guo, Min Wang, Shuai Huang and Xinsheng Peng

    Journal of Experimental & Clinical Cancer Research 2017 36:85

    Published on: 23 June 2017

  15. Research

    MiR21 sensitized B-lymphoma cells to ABT-199 via ICOS/ICOSL-mediated interaction of Treg cells with endothelial cells

    MicroRNAs (miRs) are involved in tumor progression by regulating tumor cells and tumor microenvironment. MiR21 is overexpressed in diffuse large B-cell lymphoma (DLBCL) and its biological impact on tumor micro...

    Zhong Zheng, Peng-Peng Xu, Li Wang, Hui-Jin Zhao, Xiang-Qin Weng, Hui-Juan Zhong, Bin Qu, Jie Xiong, Yan Zhao, Xue-Feng Wang, Anne Janin and Wei-Li Zhao

    Journal of Experimental & Clinical Cancer Research 2017 36:82

    Published on: 21 June 2017

  16. Research

    The role of NLRP3 inflammasome in 5-fluorouracil resistance of oral squamous cell carcinoma

    5-Fluorouracil (5-FU) is a widely used drug for the therapy of cancer. However, the chemoresistance of tumor cells to 5-FU usually limits its clinical effectiveness. In this study, we explored the role of NLRP...

    Xiaodong Feng, Qingqiong Luo, Han Zhang, Han Wang, Wantao Chen, Guangxun Meng and Fuxiang Chen

    Journal of Experimental & Clinical Cancer Research 2017 36:81

    Published on: 21 June 2017

  17. Review

    Type II CRISPR/Cas9 approach in the oncological therapy

    CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a prokaryotic adaptable immune mechanism used by many bacteria and archaea to protect themselves from foreign nucleic acids. This complex s...

    A. Biagioni, A. Chillà, E. Andreucci, A. Laurenzana, F. Margheri, S. Peppicelli, M. Del Rosso and G. Fibbi

    Journal of Experimental & Clinical Cancer Research 2017 36:80

    Published on: 15 June 2017

  18. Research

    Platinum-containing compound platinum pyrithione suppresses ovarian tumor proliferation through proteasome inhibition

    Ovarian carcinoma is one of the most aggressive gynecological malignant neoplasms and makes up 25–30% of all cancer cases of the female genital tract. Currently, resistance to traditional chemotherapy is a gre...

    Hongbiao Huang, Ni Liu, Yuning Liao, Ningning Liu, Jianyu Cai, Xiaohong Xia, Zhiqiang Guo, Yanling Li, Qirong Wen, Qi Yin, Yan Liu, Qingxia Wu, Dhivya Rajakumar, Xiujie Sheng and Jinbao Liu

    Journal of Experimental & Clinical Cancer Research 2017 36:79

    Published on: 15 June 2017

  19. Research

    ANGPTL1 attenuates colorectal cancer metastasis by up-regulating microRNA-138

    Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Nevertheless, its effects on colorectal cance...

    Haiyan Chen, Qian Xiao, Yeting Hu, Liubo Chen, Kai Jiang, Yang Tang, Yinuo Tan, Wangxiong Hu, Zhanhuai Wang, Jinjie He, Yue Liu, Yibo Cai, Qi Yang and Kefeng Ding

    Journal of Experimental & Clinical Cancer Research 2017 36:78

    Published on: 12 June 2017

  20. Research

    Angiotensin II type 2 receptor promotes apoptosis and inhibits angiogenesis in bladder cancer

    Bladder cancer (BCa) is the ninth most common form of cancer in the world. There is a continuing need not only for improving the accuracy of diagnostic markers but also for the development of new treatment str...

    Nana Pei, Yingying Mao, Pengfei Wan, Xinglu Chen, Andrew Li, Huiying Chen, Jinlong Li, Renqiang Wan, Yanling Zhang, Hongyan Du, Baihong Chen, Guangyu Jiang, Minghan Xia, Colin Sumners, Guixue Hu, Dongsheng Gu…

    Journal of Experimental & Clinical Cancer Research 2017 36:77

    Published on: 9 June 2017

  21. Research

    In vitro antineoplastic effects of brivaracetam and lacosamide on human glioma cells

    Epilepsy is a frequent symptom in patients with glioma. Although treatment with antiepileptic drugs is generally effective in controlling seizures, drug-resistant patients are not uncommon. Multidrug resistanc...

    Ambra Rizzo, Sara Donzelli, Vita Girgenti, Andrea Sacconi, Chiara Vasco, Andrea Salmaggi, Giovanni Blandino, Marta Maschio and Emilio Ciusani

    Journal of Experimental & Clinical Cancer Research 2017 36:76

    Published on: 6 June 2017

  22. Research

    ERβ1 inhibits metastasis of androgen receptor-positive triple-negative breast cancer by suppressing ZEB1

    Increasing evidence has indicated an important role for estrogen receptor beta 1 (ERβ1) in breast cancer. However, the role of ERβ1 in the metastasis of androgen receptor (AR)-positive triple-negative breast c...

    Wei Song, Lin Tang, Yumei Xu, Qian Sun, Fang Yang and Xiaoxiang Guan

    Journal of Experimental & Clinical Cancer Research 2017 36:75

    Published on: 5 June 2017

  23. Research

    Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells

    Multiple studies concluded that oncometabolites (e.g. D-2-hydroxyglutarate (2-HG) related to mutant isocitrate dehydrogenase 1/2 (IDH1/2) and lactate) have tumour promoting potential. Regulatory mechanisms implic...

    Zoltán Hujber, Gábor Petővári, Norbert Szoboszlai, Titanilla Dankó, Noémi Nagy, Csilla Kriston, Ildikó Krencz, Sándor Paku, Olivér Ozohanics, László Drahos, András Jeney and Anna Sebestyén

    Journal of Experimental & Clinical Cancer Research 2017 36:74

    Published on: 2 June 2017

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