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  1. Content type: Review

    In the advent of Immune Checkpoint inhibitors (ICI) and of CAR-T adoptive T-cells, the new frontier in Oncology is Cancer Immunotherapy because of its ability to provide long term clinical benefit in metastati...

    Authors: Luigi Aurisicchio, Matteo Pallocca, Gennaro Ciliberto and Fabio Palombo

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:86

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  2. Content type: Research

    Improvement in genetic characterization of Colon Cancer (CC) patients is required to propose new potential targets, since surgical resection coupled to chemotherapy, presents several limits such as cancer recu...

    Authors: Duarte Mendes Oliveira, Katia Grillone, Chiara Mignogna, Valentina De Falco, Carmelo Laudanna, Flavia Biamonte, Rosa Locane, Francesco Corcione, Massimiliano Fabozzi, Rosario Sacco, Giuseppe Viglietto, Donatella Malanga and Antonia Rizzuto

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:84

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  3. Content type: Research

    Distant metastasis is the major cause of treatment failure in patients with nasopharyngeal carcinoma (NPC). Although several biomarkers correlate with metastasis and prognosis, the molecular mechanisms of NPC ...

    Authors: Wen-Ze Qiu, Hai-Bo Zhang, Wei-Xiong Xia, Liang-Ru Ke, Jing Yang, Ya-Hui Yu, Hu Liang, Xin-Jun Huang, Guo-Ying Liu, Wang-Zhong Li, Yan-Qun Xiang, Tie-Bang Kang, Xiang Guo and Xing Lv

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:85

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  4. Content type: Research

    Recent studies have reported that microRNAs (miRNAs) often function as negative post-transcriptional regulators with altered expression levels found in colorectal cancer (CRC). There have been few studies on m...

    Authors: Ling Cao, Yulin Liu, Dan Wang, Lan Huang, Feng Li, Jinbo Liu, Chaoqi Zhang, Zhibo Shen, Qun Gao, Weitang Yuan and Yi Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:83

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  5. Content type: Research

    Our previous study demonstrates that Citrus-limon derived nanovesicles are able to decrease colon cancer cell viability, and that this effect is associated with the downregulation of the intracellular phospholipa...

    Authors: Stefania Raimondo, Marta Cristaldi, Simona Fontana, Laura Saieva, Francesca Monteleone, Giovanna Calabrese, Gianluca Giavaresi, Rosalba Parenti and Riccardo Alessandro

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:82

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  6. Content type: Research

    Accumulating evidence has indicated that long non-coding RNAs (lncRNAs) behave as a novel class of transcription products during multiple cancer processes. However, the mechanisms responsible for their alterat...

    Authors: Yi Xu, Yue Yao, Xingming Jiang, Xiangyu Zhong, Zhidong Wang, Chunlong Li, Pengcheng Kang, Kaiming Leng, Daolin Ji, Zhenglong Li, Lining Huang, Wei Qin and Yunfu Cui

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:81

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  7. Content type: Research

    Glioma is a heterogeneous, invasive primary brain tumor with a wide range of patient survival and a lack of reliable prognostic biomarkers. Human telomerase reverse transcriptase (hTERT) has been reported in t...

    Authors: Guihong Li, Jing Shen, Junguo Cao, Guangtong Zhou, Ting Lei, Yuxue Sun, Haijun Gao, Yaonan Ding, Weidong Xu, Zhixin Zhan, Yong Chen and Haiyan Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:78

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  8. Content type: Research

    Growth differentiation factor 15 (GDF15) is a member of the TGF-β superfamily, and evidence suggests that a substantial amount of GDF15 is secreted in various human cancers, such as ovarian cancer, prostate ca...

    Authors: Shan Li, Yan-Min Ma, Peng-Sheng Zheng and Ping Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:80

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  9. Content type: Commentary

    This commentary highlights the findings by Mai, et al. that ironomycin, derivatives of salinomycin, exhibited more potent and selective therapeutic activity against breast cancer stem cells by accumulating and...

    Authors: Bin Zhao, Xin Li, Ye Wang and Peng Shang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:79

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  10. Content type: Research

    By regulating target genes, microRNAs play essential roles in carcinogenesis and drug resistance in human pancreatic ductal adenocarcinoma (PDAC). Previous studies have shown that microRNA-10a-5p (miR-10a-5p) ...

    Authors: Guangbing Xiong, Hua Huang, Mengyu Feng, Gang Yang, Suli Zheng, Lei You, Lianfang Zheng, Ya Hu, Taiping Zhang and Yupei Zhao

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:76

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  11. Content type: Research

    Dying cells after irradiation could promote the repopulation of surviving cancer cells leading to tumor recurrence. We aim to define the role of dying cells in promoting pancreatic cancer cells metastasis foll...

    Authors: Xuelian Chen, Lirong Zhang, Yujie Jiang, Lian Song, Yanfang Liu, Fang Cheng, Xin Fan, Xiongfeng Cao, Aihua Gong, Dongqing Wang and Haitao Zhu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:77

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  12. Content type: Research

    Controlling vascular growth is a challenging aim for the inhibition of tumor growth and metastasis. The amoeboid and mesenchymal types of invasiveness are two modes of migration interchangeable in cancer cells...

    Authors: Anastasia Chillà, Francesca Margheri, Alessio Biagioni, Mario Del Rosso, Gabriella Fibbi and Anna Laurenzana

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:74

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  13. Content type: Research

    Current insights into the effects of iron deficiency in tumour cells are not commensurate with the importance of iron in cell metabolism. Studies have predominantly focused on the effects of oxygen or glucose ...

    Authors: Maida De Bortoli, Elena Taverna, Elisa Maffioli, Patrizia Casalini, Francesco Crisafi, Vikas Kumar, Claudio Caccia, Dario Polli, Gabriella Tedeschi and Italia Bongarzone

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:75

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  14. Content type: Research

    Despite SGK1 has been identified and characterized as a tumor-promoting gene, the functions and underlying mechanisms of SGK1 involved in metastasis regulation have not yet been investigated in cancer.

    Authors: Weiwei Liu, Xuchu Wang, Yiyun Wang, Yibei Dai, Yiyi Xie, Ying Ping, Binbin Yin, Pan Yu, Zhenping Liu, Xiuzhi Duan, Zhaoping Liao, Yuhua Chen, Chunhua Liu, Xiang Li and Zhihua Tao

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:73

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  15. Content type: Research

    Our previous work showed that some Rho GTPases, including Rho, Rac1 and Cdc42, play critical roles in gastric cancer (GC); however, how they are regulated in GC remains largely unknown. In this study, we aimed...

    Authors: Xiaowei Li, Mingzuo Jiang, Di Chen, Bing Xu, Rui Wang, Yi Chu, Weijie Wang, Lin Zhou, Zhijie Lei, Yongzhan Nie, Daiming Fan, Yulong Shang, Kaichun Wu and Jie Liang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:71

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  16. Content type: Research

    Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression. We and others find that YAP is up-regulated in pancreatic duc...

    Authors: Zhengdong Jiang, Cancan Zhou, Liang Cheng, Bin Yan, Ke Chen, Xin Chen, Liang Zong, Jianjun Lei, Wanxing Duan, Qinhong Xu, Xuqi Li, Zheng Wang, Qingyong Ma and Jiguang Ma

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:69

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  17. Content type: Research

    Drug resistance of B-cell precursor acute lymphoblastic leukemia (BP-ALL) cells is conferred by both intrinsic and extrinsic factors, which could be targeted to promote chemo-sensitization. Our previous studie...

    Authors: Helicia Paz, Eun Ji Joo, Chih-Hsing Chou, Fei Fei, Kevin H. Mayo, Hisham Abdel-Azim, Haike Ghazarian, John Groffen and Nora Heisterkamp

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:67

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  18. Content type: Research

    Tumor microenvironments (TMEs) activate various axes/pathways, predominantly inflammatory and hypoxic responses, impact tumorigenesis, metastasis and therapeutic resistance significantly. Although molecular pa...

    Authors: Yen-Hsiu Yeh, Ho-Fu Hsiao, Yen-Cheng Yeh, Tien-Wen Chen and Tsai-Kun Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:70

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  19. Content type: Research

    Cell cycle regulators have gain attention as potential targets for anticancer therapy. Palbociclib is a selective inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/6), which coordinate the G1-S transitio...

    Authors: Daniele Cretella, Andrea Ravelli, Claudia Fumarola, Silvia La Monica, Graziana Digiacomo, Andrea Cavazzoni, Roberta Alfieri, Alessandra Biondi, Daniele Generali, Mara Bonelli and Pier Giorgio Petronini

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:72

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  20. Content type: Research

    Detecting an ALK fusion gene in patients with non-small cell lung cancer (NSCLC) could provide evidence to guide individualized therapy.

    Authors: Yongqing Tong, Zhijun Zhao, Bei Liu, Anyu Bao, Hongyun Zheng, Jian Gu, Mary McGrath, Ying Xia, Bihua Tan, Chunhua Song and Yan Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:68

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  21. Content type: Research

    PHD-finger domain protein 5A (PHF5A) is a highly conserved small transcriptional regulator also involved in pre-mRNA splicing; however, its biological functions and molecular mechanisms in non-small cell lung ...

    Authors: Yan Yang, Jian Zhu, Tiantian Zhang, Jing Liu, Yumei Li, Yue Zhu, Lingjie Xu, Rui Wang, Fang Su, Yurong Ou and Qiong Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:65

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  22. Content type: Research

    The adipocyte remodeling, including of the morphological change, might indicate special pathological function. Our previous study found that the morphological remodeling of larger marrow adipocytes into small ...

    Authors: Wei Lu, Yun Wan, Zhiqiang Li, Bin Zhu, Chunrong Yin, Haiyan Liu, Shaoxin Yang, Yuanmei Zhai, Yehua Yu, Yanyu Wei and Jun Shi

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:66

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  23. Content type: Research

    miR-141 is up-regulated and plays crucial roles in nasopharyngeal carcinoma (NPC). However, the molecular mechanism underlying the dysregulation of miR-141 is still obscure.

    Authors: Yukun Liu, Ran Zhao, Yanmei Wei, Mengna Li, Heran Wang, Weihong Niu, Yao Zhou, Yuanzheng Qiu, Songqing Fan, Yihao Zhan, Wei Xiong, Yanhong Zhou, Xiaoling Li, Zheng Li, Guiyuan Li and Ming Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:64

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  24. Content type: Research

    The bcr-abl fusion gene is the pathological origin of chronic myeloid leukemia (CML) and plays a critical role in the resistance of imatinib. Thus, bcr-abl disruption-based novel therapeutic strategy may warra...

    Authors: Ningshu Huang, Zhenglan Huang, Miao Gao, Zhenhong Luo, Fangzhu Zhou, Lin Liu, Qing Xiao, Xin Wang and Wenli Feng

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:62

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  25. Content type: Research

    Metformin is a commonly used drug for the treatment of diabetes. Accumulating evidence suggests that it exerts anti-tumor effects in many cancers, including multiple myeloma (MM); however, the underlying molec...

    Authors: Yan Wang, Wenbin Xu, Zixun Yan, Weili Zhao, Jianqing Mi, Junmin Li and Hua Yan

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:63

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