Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer

Table 4 The average positive cell number of CXCL12, CXCR4, MMP-2, MMP-9, and NGF expression in the three groups ( $\bar{x}$ ± s)

Treatment	n	CXCL12	CXCR4	MMP-2	MMP-9	NGF
AMD3100	10	11.64 ± 4.96	19.81 ± 0.91	13.94 ± 4.63	12.96 ± 3.20	24.25 ± 5.41
Untreated control	10	18.30 ± 6.53	26.09 ± 5.48	22.47 ± 3.30	18.72 ± 3.26	31.72 ± 3.38
CXCL12	8	34.63 ± 5.04	53.83 ± 5.75	41.03 ± 8.21	32.97 ± 6.97	51.24 ± 13.87
F value		18.77	78.05	40.54	32.66	22.54

The differences of positive cell number of CXCL12, CXCR4, MMP-2, MMP-9 and NGF expression of tumor cells among the three groups were all statistically significant(P < 0.05).

ISSN: 1756-9966