Figure 2

Increased serum levels of IP-10 after intramuscular administration of IP-10 plasmid. Empty plasmid (control, 100 μg, open circles) or selected doses of IP-10 plasmid (12.5 μg, solid circles, 50 μg, open rhombus, 100 μg, solid rhombus, 200 μg, open triangles) were administered by intramuscular injection. Mice were treated twice weekly over a 4-week period. Serum was collected on days 0, 2, 7, 14, 21, 28 and 35. IP-10 protein was determined by ELISA.