Figure 8

Increased lymphocytes infiltration induced by IP-10 plasmid combined with GEM (× 200). Representative sections of four treated groups from H22 neoplasm tissue were photomicrographed at ×200 magnification (A-D). A few lymphocytes infiltrated in tumor tissues of normal saline group (A). Lymphocyte infiltration increased by administration of GEM (B) or IP-10 plasmid DNA (C). A further increase of lymphocyte infiltration was induced by IP-10 DNA combined with GEM (D) in H22 and LL/2 tumor tissues (E). *, P < 0.01 versus normal saline; and **, P < 0.01 versus GEM alone and IP-10 alone.