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Table 3 Major Adverse Events

From: Multicenter safety study of mFOLFOX6 for unresectable advanced/recurrent colorectal cancer in elderly patients

Grade ≥ 3 < 70 Years (n = 14) ≥ 70 Years (n = 8) P values*
Leukocytopenia 2 [14.3%] 1 [12.5%] 0.7090
Neutropenia 4 [28.6%] 5 [62.5%] 0.1347
Anemia 0 [0.0%] 0 [0.0%] -
Thrombocytopenia 0 [0.0%] 0 [0.0%] -
Nausea 2 [14.3%] 0 [0.0%] 0.3939
Anorexia 1 [7.1%] 1 [12.5%] 0.6060
Fatigue 1 [7.1%] 1 [12.5%] 0.6060
Stomatitis 1 [7.1%] 0 [0.0%] 0.6363
Hand-foot syndrome 1 [7.1%] 0 [0.0%] 0.6363
Peripheral Neuropathy    
   Grade1 12 [86.4%] 7 [87.5%] 0.7090
   Grade2 6 [45.5%] 4 [50.0%] 0.5464
   Grade3 2 [14.3%] 1 [12.5%] 0.7090
  1. Grades of adverse events were defined according to NCI-CTC v3.0
  2. *P values were calculated with the use of Fisher's exact probability test.